Journal of Molecular Medicine, Год журнала: 2024, Номер unknown
Опубликована: Дек. 6, 2024
Язык: Английский
Nature reviews. Cancer, Год журнала: 2024, Номер 24(9), С. 597 - 613
Опубликована: Июль 29, 2024
Язык: Английский
Процитировано
36
MedComm, Год журнала: 2024, Номер 5(12)
Опубликована: Ноя. 24, 2024
Exosomes can regulate the malignant progression of tumors by carrying a variety genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial-mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, immune escape. In microenvironment (TME), circRNAs be transferred among cells, endothelial cancer-associated fibroblasts, microbiota, affecting initiation progression. Due high stability widespread presence circRNAs, they hold promise biomarkers for diagnosis prognosis prediction blood urine. addition, designing nanoparticles targeting utilizing derived from cells or stem provide new strategies cancer therapy. this review, we examined crucial role regulating tumor-related signaling pathways summarized transmission between various types their impact on TME. Finally, our review highlights potential diagnostic prognostic biomarkers, well suggesting clinical
Язык: Английский
Процитировано
4
Cancer Medicine, Год журнала: 2025, Номер 14(1)
Опубликована: Янв. 1, 2025
ABSTRACT Background Cancer is the second leading cause of human mortality worldwide. Extracellular vesicles (EVs) from liquid biopsy samples are used in early cancer detection, characterization, and surveillance. Exosomes a subset EVs produced by all cells present body fluids. They play an important role development because they active transporters capable carrying contents any type cell. The objective this review was to provide brief overview clinical implication exosomes or exosomal components diagnosis prognosis. Methods An extensive current literature their prognosis were carried out study. Results Tumor release that contribute formation pre‐metastatic microenvironment, angiogenesis, invasion, treatment resistance. On contrary, tumor more than normal cells, these tumor‐specific can carry genomic proteomic signature which act as tools for patients with cancers. Conclusion This information may help clinicians improve management settings future.
Язык: Английский
Процитировано
0
Clinical & Translational Oncology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Язык: Английский
Процитировано
0
Epigenomics, Год журнала: 2025, Номер unknown, С. 1 - 24
Опубликована: Март 5, 2025
Solid tumors are significant causes of global mortality and morbidity. Recent research has primarily concentrated on finding pathology-specific molecules that can be acquired non-invasively change as the disease progresses or in response to treatment. The focus moved RNA either freely circulating body fluids bundled microvesicles exosomes because their great stability challenging environments, ease accessibility, changes level therapy. In this context, there many non-coding RNAs used for purpose liquid biopsies. Out these, microRNAs have been extensively studied. However, an increase interest studying long RNAs, piwi interacting circular other small RNAs. article, overview most researched solid will reviewed, along with a discussion significance these early diagnosis, prognosis, therapeutic targets. publications analyzed were extracted from PubMed database between 2008 June 2024.
Язык: Английский
Процитировано
0
Technology in Cancer Research & Treatment, Год журнала: 2025, Номер 24
Опубликована: Март 1, 2025
Breast cancer is one of the leading causes cancer-related deaths in women worldwide. Circular RNAs (circRNAs), a novel class endogenous noncoding RNA with covalently closed continuous loop that lacks 5′-cap structure and 3′-poly A tail, are more stable than linear less susceptible to degradation by nucleases. CircRNAs widespread multiple mammalian genomes have been detected various tissues, cells body fluids. Increasing evidence shows abnormal expression circRNAs involved development variety diseases, including breast cancer. Numerous studies explored potential as biomarkers malignant tumors. In this review, we aim provide comprehensive overview latest advances promising early diagnosis, prognosis, molecular type, metastasis drug resistance
Язык: Английский
Процитировано
0
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Апрель 15, 2025
Abstract Annexin A2 (ANXA2) is a multifunctional protein that binds to calcium and phospholipids plays critical role in various pathological conditions, including cancer inflammation. Recently, there has been increasing recognition of the significant ANXA2 inhibiting apoptosis promoting immune evasion tumour cells. Therefore, deep understanding regulatory mechanisms cell its relationship with can provide new targets for therapy. This review summarizes regulating cells, connection between regulation immunity, potential therapy resistance.
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217735 - 217735
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Апрель 24, 2025
Abstract Breast cancer (BC) poses significant challenges globally, necessitating a deeper understanding of its complexities. Exosomes are cell-specific secreted extracellular vesicles interest, characterized by lipid bilayer structure. can carry variety bioactive components, including nucleic acids, lipids, amino and small molecules, to mediate intercellular signaling. CircRNAs novel class single-stranded RNA closed-loop mainly exert ceRNA functions intricately modulate gene expression signaling pathways in breast cancer, influencing tumor progression therapeutic responses. The unique packaging circRNAs within exosomes serves as genetic information transmitters, facilitating communication between BC cells microenvironmental cells, thereby regulating critical aspects progression, immune evasion, drug resistance. Besides, exosomal possess the capabilities serving diagnostic biomarkers BC, due their stability, specificity, regulatory roles tumorigenesis metastasis. Therefore, this review aims elucidate mechanisms well potential for diagnosis therapeutics. ongoing investigations will potentially revolutionize treatment paradigms improve patient outcomes BC.
Язык: Английский
Процитировано
0
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 26, 2025
Язык: Английский
Процитировано
0