Pediatric Research, Год журнала: 2023, Номер 95(5), С. 1166 - 1166
Опубликована: Дек. 2, 2023
Язык: Английский
American Journal of Obstetrics and Gynecology, Год журнала: 2024, Номер 231(4), С. 460.e1 - 460.e17
Опубликована: Фев. 16, 2024
Язык: Английский
Процитировано
12
Pediatrics International, Год журнала: 2025, Номер 67(1)
Опубликована: Янв. 1, 2025
Abstract Background We aimed to reveal the transmission rate of coronavirus disease 2019 (COVID‐19) and clinical features congenital neonatal COVID‐19 disclose efficacy maternally transferred antibodies by maternal vaccination against severe acute respiratory syndrome 2 (SARS‐CoV‐2). Methods This multicenter, prospective observational study included a comprehensive testing protocol with appropriate precautions. Mothers infants were enrolled classified into an active infection group (mothers at delivery), postinfection recovered from during pregnancy), vaccinated pregnancy). Specimen collections, polymerase chain reaction assays, anti‐SARS‐CoV‐2 antibody measurements, examinations conducted for 6 months delivery. Results Sixty‐nine mothers 70 enrolled. SARS‐CoV‐2 was detected in placenta 22% 21% group. Neither nor SARS‐CoV‐2‐specific IgM infants. No anomalies, functional disorders, or developmental problems observed months. Compared group, there significant increase titers according number vaccinations, which maintained longer than first month life. Conclusions Vertical not despite protocol. more often placenta, appeared prevent vertical transmission. Maternal increased considered immunologically efficient. Vaccination pregnancy is important preventing congenital, neonatal, infantile COVID‐19.
Язык: Английский
Процитировано
1
Drug Safety, Год журнала: 2024, Номер 47(10), С. 991 - 1010
Опубликована: Июль 15, 2024
Pregnant persons are susceptible to significant complications following COVID-19, even death. However, worldwide COVID-19 vaccination coverage during pregnancy remains suboptimal.
Язык: Английский
Процитировано
6
Journal of Korean Medical Science, Год журнала: 2025, Номер 40
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Pediatrics, Год журнала: 2024, Номер 12
Опубликована: Апрель 19, 2024
Introduction Despite recommendations for COVID-19 vaccination in pregnant people, the effect of on neonatal outcomes remains unknown. We sought to determine association between status pregnancy and presence neonatally diagnosed congenital anomalies. Methods A comprehensive vaccine registry was combined with a delivery database create cohort including all patients aged 16–55 years event December 10, 2020 31, 2021 at hospital within Mayo Clinic Health System. Pregnancy were analyzed relation timing, composite measure anomalies life. Comparisons cohorts conducted using chi-square test categorical Kruskal–Wallis continuous variables. multivariable logistic regression modeled assess Results 5,096 mother-infant pairs analyzed. total 1,158 vaccinated, 314 vaccinated first trimester. status, during trimester pregnancy, not associated an increased risk When further examining by organ system, we did demonstrate significant difference eye, ear, face, neck groups (Table 3, Not = 2.3%, Vaccinated 3.3%, p -value 0.04) however this 1st (Not Trimester 2.5%, 0.77). No differences found or any other systems. There no birthweight gestational age, APGAR scores, incidence NICU admission, living neonate status. Conclusion add additional information regarding safety timing as it pertains anomalies, demonstrated. Our findings agree prior literature that is adverse small age neonates. Further research needed elucidate neck,
Язык: Английский
Процитировано
4
Transactions of the Royal Society of Tropical Medicine and Hygiene, Год журнала: 2024, Номер 118(7), С. 405 - 425
Опубликована: Янв. 31, 2024
Abstract We aimed to estimate the associations between coronavirus disease 2019 (COVID-19) vaccination during pregnancy and risks of adverse perinatal outcomes. performed a literature search in PubMed, Web Science Embase identify eligible studies published up 24 September 2023, yielding 39 included studies. Pooled relative (RRs) with 95% confidence intervals (CIs) were calculated random effects model. The pooled results showed that COVID-19 (any type or dose any trimester) was not associated an increased risk In particular, third trimester decreased preterm birth (<37 weeks) (RR 0.85 [95% CI 0.74 0.98]), 5-min Apgar <7 0.87 0.78 0.97]) neonatal intensive care unit (NICU) admission 0.90 0.86 0.95]). inverse also found analysis one-dose miscarriage 0.83 0.72 0.96]) 0.80 1.00]) two-dose NICU 0.76 0.96]). does increase negative outcomes for mother baby.
Язык: Английский
Процитировано
2
Vaccines, Год журнала: 2023, Номер 11(3), С. 640 - 640
Опубликована: Март 13, 2023
(1) Background and Aim: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is linked to increasing cases of disease 2019 (COVID-19) around the world. COVID-19 infections have an important impact on pregnancy, preterm birth (PTB) delivery. Although several complications been reported in infected pregnant women, effect infection PTB controversial. purpose this study was summarize existing literature effects health women babies its incidence PTB. We also discuss current vaccines during pregnancy. (2) Methods: carried out a systematic search MEDLINE, Embase, PubMed for studies births associated with COVID-19. (3) Results Conclusions: discovered contradictory results regarding prevalence pandemic compared earlier years. While most indicated increase PTBs COVID-19, some decline delivery rate time. During can cesarean section, stillbirth, ICU admission, preeclampsia/eclampsia, mortality rates. In treatment methylprednisolone favored over prednisolone, brief course dexamethasone advised anticipated accelerate development fetal lung. Generally, vaccination lactating stimulates anti-SARS-CoV2 immune responses, it does not result any noteworthy negative reactions or outcomes mother baby.
Язык: Английский
Процитировано
5
Vaccine, Год журнала: 2023, Номер 41(49), С. 7450 - 7459
Опубликована: Ноя. 1, 2023
Язык: Английский
Процитировано
4
Clinics in Perinatology, Год журнала: 2024, Номер 52(1), С. 101 - 113
Опубликована: Ноя. 22, 2024
Язык: Английский
Процитировано
1
Placenta, Год журнала: 2023, Номер 141, С. 84 - 93
Опубликована: Авг. 11, 2023
Excess inflammation and oxidative stress are common themes in many pathologies of pregnancy including preeclampsia more recently severe COVID-19. The risk increases following maternal infection with COVID-19, potentially relating to significant overlap pathophysiology endothelial, vascular immunological dysfunction both. Identifying a therapy which addresses these injurious processes stabilises the endothelial system would help address global burden neonatal morbidity mortality they cause. Sulforaphane is naturally occurring phytonutrient found most densely within cruciferous vegetables. It has anti-inflammatory, antioxidant immune modulating properties via upregulation phase-II detoxification enzymes. This review will cover pathways shared by COVID-19 offer potential therapeutic target nuclear factor erythroid 2-related form sulforaphane.
Язык: Английский
Процитировано
3