Donor human milk: the influence of processing technologies on its nutritional and microbial composition

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Ноя. 1, 2024

Human milk is regarded as the gold standard nutrition for newborn infants, providing all nutrients required adequate growth and development from birth to 6 months. In addition, human host an array of bioactive factors that confer immune protection infant. For this reason, supply crucial premature, seriously ill, or low weight infants (<1,500 g). When a mother’s own unavailable, donor recommended alternative by World Health Organization. Prior consumption, undergoes pasteurization ensure eradication bacterial agents prevent transfer potentially pathogenic organisms. Currently, Holder Pasteurization, heat-based treatment, widely adopted technique used banks. has demonstrated degradative effects on some milk’s biologically active factors, thus depleting critical with known functional, protective, beneficial properties, ultimately reducing immunoprotective value milk. As result, strategies processing have garnered much interest. These include thermal non-thermal techniques. current review, we describe technologies nutritional properties capacity each microbial inactivation summarized. most extensively studied, high-temperature short-time high-pressure processing, emerging yet promising techniques, microwave heating UV-C irradiation, lesser studied technologies, thermoultrasonication, retort pulsed electric field, gamma irradiation. Herein, collate findings studies, date, allow greater insight into existing gaps in scientific knowledge. It apparent lack cohesive standardized approach resulted contrasting findings, preventing direct comparative analysis research. We conclude unique valuable resource health sector, although substantial research been completed, persistent data disparities must be overcome optimal vulnerable preterm infant group, particular.

Язык: Английский

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Improving the quality of donor human milk to take advantage of more of the health benefits of mother's own milk composition

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Purpose of review Pasteurized donor human milk (PDHM) is the recommended supplement when there inadequate volume mother's own (MOM) for very low birth weight (<1500 g, VLBW) infants. Differences in composition these milks may impact growth, morbidities or long-term development The aim this to highlight current trends understanding compositional differences between MOM and PDHM, technological advances processing infant outcomes VLBW infants are fed milks. Recent findings Reported PDHM due several factors including how collected, sampled analysis, processed. Systematic reviews primary research studies demonstrate that reduces risk necrotizing enterocolitis but also associated with slower postnatal growth. Work ongoing determine if alternative approaches can improve thereby growth neurodevelopment reduce morbidity. Summary a key component feeding MOM. developments optimize source nutrition bioactive compounds while further limitations its use.

Язык: Английский

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The human milk endocannabinoidome is preserved by high hydrostatic pressure processing but altered by holder pasteurization

Frontiers in Pediatrics, Год журнала: 2025, Номер 13

Опубликована: Март 11, 2025

Introduction The microbiological safety of donor milk (DM) is commonly ensured by holder pasteurization (HoP, 62.5°C for 30 min) in human banks despite its detrimental effects on several bioactive factors. We compared the concentration twelve endocannabinoid (eCB)-like mediators raw DM and after or high hydrostatic pressure processing (HHP, 350 MPa at 38°C), a non-thermal substitute pasteurization. Methods measured five N-acyl-ethanolamines (NAEs) seven 2-mono-acyl-glycerols (2-MAGs) raw-DM, HHP-DM HoP-DM using high-performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Results demonstrated comparable concentrations with 2-MAGs as well N-docosapentaenoyl-ethanolamine (DHEA, an NAE). However, four other NAEs, including N-arachidonoyl-ethanolamine (AEA), N-palmitoyl-(PEA), N-oleoyl -ethanolamine (OEA) N-linoleoyl-ethanolamine (LEA) were significantly increased HoP. Conclusion Our study suggests that may more suitable than improve development preterm infants through preservation eCB level close their initial levels DM.

Язык: Английский

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High-Pressure Processing of Milk and Dairy Products: Latest Update

Processes, Год журнала: 2024, Номер 12(10), С. 2073 - 2073

Опубликована: Сен. 25, 2024

The growing global demand for minimally processed fresh foods has driven the development of innovative food processing methods. High-pressure (HPP), a leading non-thermal technique, proven to be environmentally friendly, cost-effective, and versatile across various types. Its ability extend shelf life ensure microbial safety is well established, particularly in dairy products. However, further research needed fully understand HPP’s impact on improving digestion milk compounds assessing potential risks. Recent studies, example, demonstrate efficacy enhancing nutritional value products like cheese, yogurt, whey protein isolate. This review explores these advancements highlights role physicochemical, organoleptic, functional properties

Язык: Английский

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Donor human milk treated by high‐pressure processing improves the body growth of growth‐restricted mice pups

Journal of Pediatric Gastroenterology and Nutrition, Год журнала: 2024, Номер 79(2), С. 362 - 370

Опубликована: Июнь 20, 2024

Pasteurized human donor milk (DM) is frequently used for feeding preterm newborns and extrauterine growth-restricted (EUGR) infants. Most banks performed a pasteurization of DM using the standard method Holder (HoP) which consists heating at 62.5°C 30 min. High hydrostatic pressure (HHP) processing was proposed to be an innovative nonthermal pasteurize DM. However, effect different modes on body growth, intestinal maturation, microbiota has never been investigated in vivo during lactation. We aimed study these effects postnatally (PNGR) mice pups daily supplemented with HoP-DM or HHP-DM. PNGR induced by increasing number per litter (15 pups/mother) postnatal Day 4 (PND4). From PND8 PND20, were At PND21, permeability measured vivo, mucosal histology, gut microbiota, short-chain fatty acids (SCFAs) level analyzed. HHP-DM displayed significantly higher weight gain than two types supplementations did not differentially alter morphology permeability, gene-expression several markers, caecal SCFAs level. Our data suggest that HHP could attractive alternative HoP may ensure better growth and/or EUGR

Язык: Английский

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Postnatally acquired cytomegalovirus infection among preterm infants

Current Opinion in Infectious Diseases, Год журнала: 2024, Номер 37(5), С. 425 - 430

Опубликована: Июль 31, 2024

Although there are multiple benefits of mother's own milk feeding for very-low birth weight, low gestation infants, those born to cytomegalovirus (CMV)-seropositive mothers at risk acquiring postnatal CMV infection. This review will describe the and consequences infection among very preterm infants.

Язык: Английский

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