Cancer Letters, Год журнала: 2022, Номер 553, С. 215980 - 215980
Опубликована: Ноя. 4, 2022
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3406 - 3406
Опубликована: Март 17, 2024
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies worldwide, while it persists as fourth most prevalent cause cancer-related death in United States America. Although there are several novel therapeutic strategies for approach this intensely aggressive tumor, remains a clinical challenge, hard to identify early stages, due its asymptomatic course. A diagnosis usually established when disease already late chemoresistance constitutes an obstacle optimal management malignancy. The discovery diagnostic and tools considered necessity low survival rates treatment failures. One extensively investigated potential modalities extracellular vesicles (EVs). These constitute nanosized double-lipid membraned particles that characterized by high heterogeneity emerges from their distinct biogenesis route, multi-variable sizes, particular cargoes embedded into these particles. Their pivotal role cell-to-cell communication via cargo implication pathophysiology diseases, including pancreatic cancer, opens new horizons Meanwhile, interplay between carcinogenesis short non-coding RNA molecules (micro-RNAs or miRs) spotlight current studies, they can have either tumor suppressors promoters. deregulation both aforementioned leads aberrations function cells, leading carcinogenesis. In review, we will explore miRNAs well potent utilization tools.
Язык: Английский
Процитировано
7
Journal of Experimental & Clinical Cancer Research, Год журнала: 2024, Номер 43(1)
Опубликована: Апрель 24, 2024
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal tumor and has become an important global health problem. The PI3K/AKT signaling pathway plays key role in the development of ESCC. CircRNAs have been reported to be involved regulation pathway, but underlying mechanisms are unclear. Therefore, this study aimed identify protein-coding circRNAs investigate their functions Methods Differential expression between ESCC tissues adjacent normal was identified using circRNA microarray analysis. Thereafter, LC–MS/MS used circPDE5A-encoded novel protein PDE5A-500aa. Molecular biological methods were explore regulatory circPDE5A PDE5A-500aa Lastly, circRNA-loaded nanoplatforms constructed therapeutic translation value circPDE5A. Results We found that down-regulated cells it negatively associated with advanced clinicopathological stages poorer prognosis Functionally, inhibited proliferation metastasis vitro vivo by encoding PDE5A-500aa, regulator Mechanistically, interacted PIK3IP1 promoted USP14-mediated de-ubiquitination k48-linked polyubiquitin chain at its K198 residue, thereby attenuating In addition, Meo-PEG- S–S -PLGA-based reduction-responsive loaded plasmids successfully inhibit growth vivo. Conclusion encoded can act as inhibitor progression promoting may serve potential target for agents. Graphical esophageal carcinoma.
Язык: Английский
Процитировано
7
Expert Opinion on Therapeutic Patents, Год журнала: 2024, Номер 34(3), С. 141 - 158
Опубликована: Март 3, 2024
Introduction Recent years have witnessed great achievements in drug design and development targeting the phosphatidylinositol 3-kinase/protein kinase-B (PI3K/AKT) signaling pathway, a pathway central to cell growth proliferation. The nearest neighbor protein-protein interaction networks for PI3K AKT show interplays between these target proteins which can be harnessed discovery. In this review, we discuss clinical of inhibitors PI3K/AKT past three years. We review detail structures, selectivity, efficacy, combination therapy thirty-five proteins, classified based on proteins. Approaches overcoming resistance minimizing toxicities are discussed. Future research directions developing combinational PROTACs also
Язык: Английский
Процитировано
6
Cancer Biology & Therapy, Год журнала: 2024, Номер 25(1)
Опубликована: Май 14, 2024
The potential function and mechanism of circRNAs in regulating malignant performances Osteosarcoma (OS) cells have not been well investigated. expression level CircLMO7, miR-21-5p ARHGAP24 were detected by RT-qPCR. relationship between circ-LMO7, as ARHGAP24, was predicted examined through bioinformatics analysis luciferase reporter gene experiments. Moreover, OS cell growth, invasion, migration, apoptosis using the counting kit-8 (CCK-8), transwell flow cytometry assays, respectively. protein measured western blotting. In present study, we choose to investigate role circ-LOM7 on proliferation, migration invasion. found be down-regulated tissues lines. Enforced suppressed cells. contrast, decreasing circ-LMO7 had opposite effects. Furthermore, sponged an OS. served miR-21-5pʹs downstream target. Mechanistically, packed exosomes acted a cancer-suppresser sponging upregulating ARHGAP24. exosomal significantly decreased exosomes, co-culture experiments showed that proliferation ability Circ-LMO7 exerts tumor suppressor OS, circ-LMO7/miR-21-5P/ARHGAP24 axis is involved progression.
Язык: Английский
Процитировано
6
Cancer Letters, Год журнала: 2022, Номер 553, С. 215980 - 215980
Опубликована: Ноя. 4, 2022
Язык: Английский
Процитировано
23