The emerging field of oncolytic virus-based cancer immunotherapy

Trends in cancer, Год журнала: 2022, Номер 9(2), С. 122 - 139

Опубликована: Ноя. 17, 2022

Язык: Английский

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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2024, Номер 17(1)

Опубликована: Апрель 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Язык: Английский

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γδ T cells: origin and fate, subsets, diseases and immunotherapy

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Ноя. 22, 2023

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering use allogeneic Vδ2

Язык: Английский

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Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy

Trends in Immunology, Год журнала: 2022, Номер 43(10), С. 833 - 847

Опубликована: Сен. 1, 2022

Язык: Английский

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Exploiting innate immunity for cancer immunotherapy

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Ноя. 27, 2023

Abstract Immunotherapies have revolutionized the treatment paradigms of various types cancers. However, most these immunomodulatory strategies focus on harnessing adaptive immunity, mainly by inhibiting immunosuppressive signaling with immune checkpoint blockade, or enhancing immunostimulatory bispecific T cell engager and chimeric antigen receptor (CAR)-T cell. Although agents already achieved great success, only a tiny percentage patients could benefit from immunotherapies. Actually, immunotherapy efficacy is determined multiple components in tumor microenvironment beyond immunity. Cells innate arm system, such as macrophages, dendritic cells, myeloid-derived suppressor neutrophils, natural killer unconventional also participate cancer evasion surveillance. Considering that cornerstone antitumor response, utilizing immunity provides potential therapeutic options for control. Up to now, exploiting agonists stimulator interferon genes, CAR-macrophage -natural therapies, metabolic regulators, novel exhibited potent activities preclinical clinical studies. Here, we summarize latest insights into roles cells discuss advances arm-targeted strategies.

Язык: Английский

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The Notch signaling pathway: a potential target for cancer immunotherapy

Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)

Опубликована: Май 2, 2023

Dysregulation of the Notch signaling pathway, which is highly conserved across species, can drive aberrant epigenetic modification, transcription, and translation. Defective gene regulation caused by dysregulated often affects networks controlling oncogenesis tumor progression. Meanwhile, modulate immune cells involved in anti- or pro-tumor responses immunogenicity. A comprehensive understanding these processes help with designing new drugs that target signaling, thereby enhancing effects cancer immunotherapy. Here, we provide an up-to-date overview how intrinsically regulates alterations stromal extrinsically regulate microenvironment (TME). We also discuss potential role immunity mediated gut microbiota. Finally, propose strategies for targeting These include oncolytic virotherapy combined inhibition nanoparticles (NPs) loaded regulators to specifically tumor-associated macrophages (TAMs) repolarize their functions remodel TME, combining specific efficient inhibitors activators checkpoint blockers (ICBs) synergistic anti-tumor therapy, implementing a customized effective synNotch circuit system enhance safety chimeric antigen receptor (CAR) cells. Collectively, this review aims summarize shapes improve

Язык: Английский

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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Язык: Английский

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CAFs orchestrates tumor immune microenvironment—A new target in cancer therapy?

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Март 14, 2023

Cancer immunotherapy has opened a new landscape in cancer treatment, however, the poor specificity and resistance of most targeted therapeutics have limited their therapeutic efficacy. In recent years, role CAFs immune regulation been increasingly noted as more evidence uncovered regarding link between cancer-associated fibroblasts (CAFs) evolutionary process tumor progression. interact with cells to shape microenvironment (TIME) that favors malignant progression, crosstalk leads failure immunotherapies. this review, we outline advances immunosuppressive function CAFs, highlight mechanisms CAFs-immune cell interactions, discuss current CAF-targeted strategies for future study.

Язык: Английский

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The paradoxical role of cytokines and chemokines at the tumor microenvironment: a comprehensive review

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Фев. 15, 2024

Abstract Tumor progression and eradication have long piqued the scientific community's interest. Recent discoveries about role of chemokines cytokines in these processes fueled renewed interest related research. These roles are frequently viewed as contentious due to their ability both suppress promote cancer progression. As a result, this review critically appraised existing literature discuss unique tumor microenvironment, well challenges future opportunities for exploiting develop novel targeted treatments. While modulatory molecules play an important suppression via enhanced cancer-cell identification by cytotoxic effector cells directly recruiting immunological stromal TME, we observed that they also proliferation. Many cytokines, including GM-CSF, IL-7, IL-12, IL-15, IL-18, IL-21, entered clinical trials people with advanced cancer, while FDA has approved interferon-alpha IL-2. Nonetheless, low efficacy dose-limiting toxicity limit agents' full potential. Conversely, Chemokines tremendous potential increasing immune-cell penetration microenvironment promoting beneficial interactions. When combined activate lymphocytes, producing IL-2, CD80, all which strong anticancer effect. This phenomenon opens door development effective combination therapies, such therapies can reverse escape, chemotaxis immunosuppressive like Tregs, MDSCs, TAMs.

Язык: Английский

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CAR-NK cells for cancer immunotherapy: recent advances and future directions

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 9, 2024

Natural Killer (NK) cells, intrinsic to the innate immune system, are pivotal in combating cancer due their independent cytotoxic capabilities antitumor response. Unlike predominant treatments that target T cell immunity, limited success of immunotherapy emphasizes urgency for innovative approaches, with a spotlight on harnessing potential NK cells. Despite tumors adapting mechanisms evade cell-induced cytotoxicity, there is optimism surrounding Chimeric Antigen Receptor (CAR) This comprehensive review delves into foundational features and recent breakthroughs comprehending dynamics cells within tumor microenvironment. It critically evaluates applications challenges associated emerging CAR-NK therapeutic strategies, positioning them as promising tools evolving landscape precision medicine. As research progresses, unique attributes offer new avenue interventions, paving way more effective precise approach treatment.

Язык: Английский

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