The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 419 - 419

Опубликована: Янв. 6, 2025

High-density lipoprotein (HDL) is associated with decreased incidence of cardiovascular events, and its functionality also influences prognosis. Exercise an important tool to improve prognosis in the post-infarction (MI) population, but role exercise on HDL poorly understood. Sixty-two patients acute MI were randomized a supervised program for 12–14 weeks (exercise group—EG) or control group (CG). The main objective study was analyze esterified cholesterol (EC) unesterified (UC) transfer HDL. For total baseline mean rate EC 2.53 ± 0.83 at end follow-up, it 2.74 0.64 (p = 0.03). figures UC were, respectively, 4.08 1.2 4.4 1.06 0.02). difference (follow-up minus baseline) 0.15 0.84 0.27 0.69 0.53); UC, 0.28 1.14 0.35 0.96 0.80), groups. In post-MI patients, did not functionality.

Язык: Английский

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Evaluation of Exercise Rehabilitation Programs to Improve Cardiac and Respiratory Health in COVID-19 Patients: A Systematic Review of Randomized Controlled Trials

Global Journal of Medical Pharmaceutical and Biomedical Update, Год журнала: 2025, Номер 20, С. 1 - 1

Опубликована: Янв. 31, 2025

Introduction: Coronavirus disease 2019 (COVID-19) survivors have suffered from long-term impacts of the disease. Many are experiencing persistent cardiac and respiratory complications. Some studies shown that exercise-based rehabilitation plays a critical role in recovery post-COVID-19 patients order to minimize complications such as dyspnea, breathlessness, heart failure. Objective: The objective this study was evaluate effectiveness programs improve functions COVID-19 patients. Methodology: An extensive search literature conducted on PubMed, Cochrane Central Register Controlled Trials, TRIP databases using following keywords Boolean operators: High intensity interval training (HIIT) OR exercise AND long COVID. Randomized controlled trials (RCTs) published English language 2020 2024 were included study. Full-text articles reviewed Preferred Reporting Items for Systematic Reviews Meta-Analyses guidelines implemented during systematic review. Patients who had pre-existing excluded Results: This review 5 RCTs involving 291 participants. (intervention) groups showed notable improvements VO2 peak with pooled data (ES = 0.765, SE 0.193, 95% confidence [CI] 0.391, 1.139). mean difference (MD) 2.42, maximum, rate (HR max) increased (MD 5.33), left ventricular mass by MD 6.8 (95% CI: 0.8; 12.8 g; P 0.029) indicating enhanced cardiovascular conditioning function. Maximum voluntary ventilation 5.3) improved endurance along an stability FEV1 FVC. In addition, drastic improvement ventilatory efficiency breathing patterns noted, thus reducing perceived dyspnea. HIIT intervention: Two participants reduction their predicted residual volume % (8%) total lung capacity. comparison, control group no significant improvement. Conclusion: Exercise-based decreasing symptoms palpitations, By integrating into post-COVID care, can be significantly improved.

Язык: Английский

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The Mechanism by Which Estrogen Level Affects Knee Osteoarthritis Pain in Perimenopause and Non-Pharmacological Measures

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2391 - 2391

Опубликована: Март 7, 2025

Perimenopausal women have fluctuating estrogen levels, which often trigger a range of symptoms perimenopausal syndromes as levels decrease. Changes in are closely related to pain knee osteoarthritis (KOA), has long been research area great interest women. In recent years, it found that an important role KOA pain, namely, can affect through the regulation inflammatory responses, inhibition cellular senescence and apoptosis, modulation neurotransmitters, may provide new ideas for treatment. This study aims describe mechanism level on perimenopause non-pharmacological measures, such physical therapy, factor traditional Chinese medicine, diet, reference treatment with KOA.

Язык: Английский

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A Hierarchical Mechanotransduction System: From Macro to Micro

Advanced Science, Год журнала: 2023, Номер 11(11)

Опубликована: Дек. 25, 2023

Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including forces and properties, are sensed translated into biochemical signals. Increasing data demonstrate that mechanotransduction crucial for regulating macroscopic microscopic dynamics functionalities. However, the actions mechanisms of across multiple hierarchies, from molecules, subcellular structures, cells, tissues/organs, to whole-body level, have not been yet comprehensively documented. Herein, biological roles operational macro micro revisited, with focus on orchestrations diverse hierarchies. The implications, applications, challenges in human diseases also summarized discussed. Together, this knowledge hierarchical perspective has potential refresh insights regulation disease pathogenesis therapy, ultimately revolutionize prevention, diagnosis, treatment diseases.

Язык: Английский

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Physical activity, exercise and adverse cardiovascular outcomes in individuals with pre-existing cardiovascular disease: a narrative review

Expert Review of Cardiovascular Therapy, Год журнала: 2024, Номер 22(1-3), С. 91 - 101

Опубликована: Март 3, 2024

The evidence supporting the cardiovascular health benefits of physical activity and/or exercise training is well-established. While role in primary prevention unequivocal, its significance secondary (among those with preexisting disease) less definitive. Though guidelines universally recommend as part preventive strategy, empirical underpinning these recommendations not robust that for prevention.

Язык: Английский

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Aerobic exercise mitigates high-fat diet-induced cardiac dysfunction, pyroptosis, and inflammation by inhibiting STING-NLRP3 signaling pathway

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер 479(12), С. 3459 - 3470

Опубликована: Фев. 22, 2024

Язык: Английский

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Beyond cardiomyocytes: Cellular diversity in the heart's response to exercise

Journal of sport and health science/Journal of Sport and Health Science, Год журнала: 2022, Номер 12(4), С. 423 - 437

Опубликована: Дек. 19, 2022

Cardiomyocytes comprise ∼70% to 85% of the total volume adult mammalian heart but only about 25% 35% its number cells. Advances in single cell and nuclei RNA sequencing have greatly facilitated investigation into increased appreciation potential functions non-cardiomyocytes heart. While much this work has focused on relationship between non-cardiomyocytes, disease, heart's response pathological stress, it will also be important understand roles that these cells play healthy heart, cardiac homeostasis, physiological stress such as exercise. The present review summarizes recent research highlighting dynamic changes Of particular interest are fibrotic pathways, vasculature, immune or inflammatory In many instances, limited data available how specific lineages change exercise whether observed functionally important, underscoring need for further research.

Язык: Английский

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Cardiovascular effects of weight loss in old adults with overweight/obesity according to change in skeletal muscle mass

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2023, Номер 15(1), С. 342 - 351

Опубликована: Дек. 18, 2023

Abstract Background Patients with overweight/obesity and type 2 diabetes are encouraged to lose weight, but not all losing weight gain better cardiovascular health, especially old adults. The change in skeletal muscle mass (SMM) could be the key that explains heterogenous effects of loss. This study aims assess whether loss vary for those gaining along Methods adults Look AHEAD having measurement from dual‐energy X‐ray absorptiometry were included. Based on (WC) SMM (SMMC) between baseline 4‐year follow‐up, participants allocated into three groups—weight (WG) group, (WL‐ML) group (WL‐MG) group. Cox proportional hazards regression was performed evaluate risk or compared weight. Among loss, ratio SMMC/WC calculated, association primary outcome assessed. Results A total 491 included an average age 64.56 ± 3.81 years old. 47.0% male 49.9% intensive lifestyle intervention arm. their WC SMMC, 43 assigned WG 373 WL‐ML 75 WL‐MG Over a follow‐up almost 10 years, 97 encountered endpoint. had highest incidence 25.59%, lowest 9.33% 21.18% ( P = 0.040). In fourth adjusted model, achieved significantly decreased odds endpoint (hazard [HR] 0.33, 95% confidence interval [CI] [0.12, 0.87], 0.026), whilst did (HR 0.91, CI [0.47, 1.78], 0.670). when reached around 50%, this HR soared approximately two‐fold. Conclusions adverse events, who lost comparable more during greater harm. modulated by gained meanwhile

Язык: Английский

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Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training

Journal of Cardiovascular Translational Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Язык: Английский

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Effects of defined voluntary running distances coupled with high‐fat diet consumption on the skeletal muscle transcriptome of male mice

Physiological Reports, Год журнала: 2025, Номер 13(2)

Опубликована: Янв. 1, 2025

Abstract Exercise counters many adverse health effects of consuming a high‐fat diet (HFD). However, complex molecular changes that occur in skeletal muscle response to exercising while HFD are not yet known. We investigated the interplay between diverse exercise regimes and consumption on adaptation transcriptome. C57BL/6 male mice were randomized into five groups—one sedentary control group four groups. The groups consisted an unrestricted running (8.3 km/day) three restricted 75%, 50%, or 25% (6.3, 4.2, 2.1 km/day, respectively). Total RNA was extracted from frozen gastrocnemius for transcriptome analyses. DEG counts 1347, 1823, 1103, 1107 there 107, 169, 67, 89 unique genes present HFD‐25%, HFD‐50%, HFD‐75%, HFD‐U, respectively. Comparing groups, we found at 50% resulted most differentially expressed transcripts with MAPK PPAR signaling pathways enriched down‐ up‐regulated genes, These results demonstrate distance impacts suggest middle‐distance may provide greatest protection against diet‐induced stress coupled exercise.

Язык: Английский

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