Cells,
Год журнала:
2025,
Номер
14(6), С. 410 - 410
Опубликована: Март 11, 2025
Aerobic
exercise
promotes
physiological
cardiac
adaptations,
improving
cardiovascular
function
and
endurance
capacity.
However,
the
molecular
mechanisms
by
which
aerobic
induces
adaptations
enhances
performance
remain
poorly
understood.
Mitogen-activated
protein
kinase
(MAPK)
phosphatase-5
(MKP-5)
is
highly
expressed
in
muscle,
indicating
its
potential
role
function.
This
study
investigates
of
MKP-5
early
response
to
muscle
using
MKP-5-deficient
(Mkp-5-/-)
wild-type
(Mkp-5+/+)
mice.
Mice
were
subjected
a
5-day
treadmill
training
program
after
habituation.
After
exercise,
progressive
stress
test
was
performed
evaluate
Our
results
revealed
that
exercised
mice
exhibited
significant
reduction
gene
expression
compared
sedentary
(0.19
±
5.89-fold;
p
<
0.0001).
Mkp-5-/-
achieved
significantly
greater
endurance,
with
running
distance
(2.81
169.8-fold;
0.0429)
longer
than
Mkp-5+/+
Additionally,
deficiency
enhanced
Akt/mTOR
signaling
(p-Akt/Akt:
1.29
0.12-fold;
=
0.04;
p-mTOR/mTOR:
1.59
0.14-fold;
0.002)
mitochondrial
biogenesis
(pgc-1α:
1.56
0.27-fold;
0.03)
exercise.
Furthermore,
markers
cardiomyocyte
proliferation,
including
PCNA
(2.24
0.31-fold;
0.001),
GATA4
(1.47
0.10-fold;
CITED4
(2.03
0.15-fold;
0.0001)
upregulated
hearts
following
These
findings
demonstrated
plays
critical
regulating
key
pathways
for
exercise-induced
highlighting
contribution
enhancing
health
F1000Research,
Год журнала:
2025,
Номер
13, С. 330 - 330
Опубликована: Фев. 10, 2025
Background
&
Purpose
Falls
and
balance
issues
are
significant
concerns
for
the
elderly.
Treadmill
training
is
increasingly
recognized
as
a
potential
intervention
to
improve
reduce
fall
risk
in
this
population.
This
systematic
review
evaluates
effectiveness
of
treadmill
on
Methods
A
comprehensive
search
was
conducted
databases
including
MEDLINE,
EMBASE,
CINAHL
Plus,
PEDro,
Cochrane
Library,
ERIC
from
January
1,
1980,
2025.
The
focused
training’s
impact
older
adults.
From
74
identified
studies,
primary
outcome
measure
“Balance
Improvement,
fall”
secondary
were
“Cognitive
Function
Quality
Life,”
others.
Articles
excluded
reasons
like
irrelevance
training,
language
barriers,
or
duplication,
resulting
16
final
studies.
Results
demonstrated
positive
effects
reduction,
particularly
elderly
individuals
with
Parkinson’s
disease,
spinal
cord
injuries,
age-related
issues.
Perturbation-based
significantly
reduced
rates,
while
underwater
sessions
improved
mobility
cognitive
function.
Conclusion
interventions
promising
improving
elderly,
those
While
these
show
potential,
further
research
needed
determine
optimal
protocols,
durations,
combinations
other
interventions.
could
lead
more
approach
addressing
challenges
promoting
healthy
aging
reducing
risks.
International Journal of Preventive Medicine,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 1, 2025
Angiogenesis
is
crucial
in
the
recovery
and
maintenance
of
heart
function.
Irisin
may
mediate
cardiac
health-promoting
impact
exercise
training.
The
aim
this
study
was
to
comparatively
assess
VEGF
gene/protein
expression
tissue
correlations
with
serum
irisin
levels
following
resistance
training,
comparison
exogenous
injection.
Twenty-one
NMRI
mice
were
randomly
assigned
three
group
(n
=
7
for
each
group):
control,
exercise,
irisin.
Exercised
mice,
8
weeks,
sessions
per
week
four
sets
five
repeats
session
considered
climbed
up
a
1-m-height
ladder
slope
80
degrees
weight
equal
30%
mouse's
body
fastened
their
tails
gradually
increased
twofold
weight.
received
100
μg/kg/week
intraperitoneally.
gene,
by
real-time
PCR,
level
protein,
IHC
(immunohistochemistry)
western
blot
analysis,
concentration,
ELISA,
evaluated.
gene
as
well
levels,
all
experimental
compared
control
(P
<
0.05).
Pearson's
correlation
coefficient
data
indicated
positive
between
analyzed
parameters
0.05
r
>
0).
There
appears
be
an
interaction
angiogenesis
factors,
mediated
So,
could
cardiovascular
health
interventions,
aiming
target
specific
molecules
or
pathways.
Abstract
Aging
is
driven
by
fundamental
mechanisms
like
oxidative
stress,
telomere
shortening
and
changes
in
DNA
methylation,
which
together
prepare
the
ground
for
age-related
diseases.
Botanical
extracts,
rich
bioactive
phytoconstituents,
represent
a
promising
resource
developing
therapies
that
target
these
to
promote
healthy
aging.
This
study
explores
geroprotective
potential
of
Monarda
didyma
L.
extract.
In
vitro
analyses
revealed
extract’s
strong
antioxidant
activity,
ability
reduce
shortening,
capacity
protect
against
damage,
thereby
decreasing
cellular
senescence
improving
endothelial
function.
The
randomized,
double-blind
clinical
trial
demonstrated
daily
oral
supplementation
with
extract
significantly
improved
leukocyte
length
(LTL)
stabilized
methylation
age
(DNAmAge)
intervention
group,
while
placebo
group
experienced
accelerated
epigenetic
aging
hypermethylation
critical
genes
(ELOVL2
FHL2).
also
reported
enhanced
quality
life,
particularly
physical
domain,
along
movement
sleep
indices
detected
questionnaire
wearable
sensors.
These
compelling
findings
position
as
powerful
candidate
future
therapies,
impact
Cells,
Год журнала:
2025,
Номер
14(6), С. 410 - 410
Опубликована: Март 11, 2025
Aerobic
exercise
promotes
physiological
cardiac
adaptations,
improving
cardiovascular
function
and
endurance
capacity.
However,
the
molecular
mechanisms
by
which
aerobic
induces
adaptations
enhances
performance
remain
poorly
understood.
Mitogen-activated
protein
kinase
(MAPK)
phosphatase-5
(MKP-5)
is
highly
expressed
in
muscle,
indicating
its
potential
role
function.
This
study
investigates
of
MKP-5
early
response
to
muscle
using
MKP-5-deficient
(Mkp-5-/-)
wild-type
(Mkp-5+/+)
mice.
Mice
were
subjected
a
5-day
treadmill
training
program
after
habituation.
After
exercise,
progressive
stress
test
was
performed
evaluate
Our
results
revealed
that
exercised
mice
exhibited
significant
reduction
gene
expression
compared
sedentary
(0.19
±
5.89-fold;
p
<
0.0001).
Mkp-5-/-
achieved
significantly
greater
endurance,
with
running
distance
(2.81
169.8-fold;
0.0429)
longer
than
Mkp-5+/+
Additionally,
deficiency
enhanced
Akt/mTOR
signaling
(p-Akt/Akt:
1.29
0.12-fold;
=
0.04;
p-mTOR/mTOR:
1.59
0.14-fold;
0.002)
mitochondrial
biogenesis
(pgc-1α:
1.56
0.27-fold;
0.03)
exercise.
Furthermore,
markers
cardiomyocyte
proliferation,
including
PCNA
(2.24
0.31-fold;
0.001),
GATA4
(1.47
0.10-fold;
CITED4
(2.03
0.15-fold;
0.0001)
upregulated
hearts
following
These
findings
demonstrated
plays
critical
regulating
key
pathways
for
exercise-induced
highlighting
contribution
enhancing
health
