Sub-cellular biochemistry/Subcellular biochemistry, Год журнала: 2025, Номер unknown, С. 1 - 49
Опубликована: Янв. 1, 2025
Язык: Английский
Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)
Опубликована: Сен. 12, 2023
Abstract Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen nutrients, tumor cells undergo transformations exploit various ways acquiring lipid increasing oxidation. addition, stromal immune the microenvironment also reprogramming, which further affects functional phenotypes responses. Given metabolism plays a critical role supporting cancer progression remodeling microenvironment, targeting pathway could provide novel approach treatment. This review seeks to: (1) clarify overall landscape mechanisms cancer, (2) summarize landscapes within their roles progression, (3) potential therapeutic targets for metabolism, highlight combining such approaches with other anti-tumor therapies new opportunities patients.
Язык: Английский
Процитировано
129
Molecular Cancer, Год журнала: 2023, Номер 22(1)
Опубликована: Июнь 30, 2023
Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible posttranscriptional RNA that mediated by m6A regulators or methylation regulators, i.e., methyltransferases ("writers"), demethylases ("erasers"), m6A-binding proteins ("readers"). Aberrant associated with cancer occurrence, development, progression, prognosis. Numerous studies have established aberrant function as either tumor suppressors oncogenes in multiple types. However, the functions mechanisms of remain largely elusive should be explored. Emerging suggest can modulated epigenetic modifications, namely, ubiquitination, SUMOylation, acetylation, methylation, phosphorylation, O-GlcNAcylation, ISGylation, lactylation via noncoding action, cancer. This review summarizes current roles The for modification genesis segregated. will improve understanding regulatory regulators.
Язык: Английский
Процитировано
80
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Дек. 10, 2023
Abstract Ferroptosis, a unique modality of cell death with mechanistic and morphological differences from other modes, plays pivotal role in regulating tumorigenesis offers new opportunity for modulating anticancer drug resistance. Aberrant epigenetic modifications posttranslational (PTMs) promote resistance, cancer progression, metastasis. Accumulating studies indicate that can transcriptionally translationally determine vulnerability to ferroptosis functions as driver nervous system diseases (NSDs), cardiovascular (CVDs), liver diseases, lung kidney diseases. In this review, we first summarize the core molecular mechanisms ferroptosis. Then, roles processes, including histone PTMs, DNA methylation, noncoding RNA regulation such phosphorylation, ubiquitination, SUMOylation, acetylation, ADP-ribosylation, are concisely discussed. The PTMs genesis cancers, NSD, CVDs, well application PTM modulators therapy these then discussed detail. Elucidating mediated by will facilitate development promising combination therapeutic regimens containing or PTM-targeting agents inducers be used overcome chemotherapeutic resistance could prevent addition, highlight potential approaches chemoresistance halt
Язык: Английский
Процитировано
72
Nature Reviews Molecular Cell Biology, Год журнала: 2024, Номер 25(6), С. 488 - 509
Опубликована: Фев. 14, 2024
Язык: Английский
Процитировано
50
Chemical Reviews, Год журнала: 2024, Номер 124(5), С. 2805 - 2838
Опубликована: Фев. 19, 2024
Post-translational modifications (PTMs) endow proteins with new properties to respond environmental changes or growth needs. With the development of advanced proteomics techniques, hundreds distinct types PTMs have been observed in a wide range from bacteria, archaea, and eukarya. To identify roles these PTMs, scientists applied various approaches. However, high dynamics, low stoichiometry, crosstalk between make it almost impossible obtain homogeneously modified for characterization site-specific effect individual PTM on target proteins. solve this problem, genetic code expansion (GCE) strategy has introduced into field studies. Instead modifying after translation, GCE incorporates amino acids during thus generating site-specifically at positions. In review, we summarize systems orthogonal translation installation PTMs.
Язык: Английский
Процитировано
16
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 2, 2025
Acylation stands as a fundamental process in both biological pathways and synthetic chemical reactions, with acylated saccharides their derivatives holding diverse applications ranging from bioactive agents to building blocks. A longstanding objective organic synthesis has been the site-selective acylation of without extensive pre-protection alcohol units. In this study, we demonstrate that by simply altering chirality N-heterocyclic carbene (NHC) catalysts, site-selectivity saccharide reactions can be effectively modulated. Our investigation reveals intriguing selectivity shift stems combination factors, including match/mismatch inter- / intramolecular hydrogen bonding between NHC catalyst substrates. These findings provide valuable insights into design reaction engineering, highlighting potential glycoside analysis, such fluorescent labelling, α/β identification, orthogonal selective late-stage modifications. The units synthesis. Here, authors
Язык: Английский
Процитировано
2
Pharmacological Research, Год журнала: 2025, Номер 212, С. 107588 - 107588
Опубликована: Янв. 7, 2025
Atherosclerosis, a multifactorial progressive inflammatory disease, is the common pathology underlying cardiovascular and cerebrovascular diseases. The macrophage plasticity involved in pathogenesis of atherosclerosis. With advance metabolomics epigenetics, metabolites/metabolic epigenetic modification such as DNA methylation, histone noncoding RNA, play crucial role polarization progression Herein, we provide comprehensive review essential metabolic regulation, well crosstalk between two regulating We also highlight potential therapeutic strategies via modifications for atherosclerosis, offer recommendations to our knowledge roles metabolic-epigenetic context Fundamental studies that elucidate mechanisms by which regulation influence atherosclerosis will pave way novel approaches.
Язык: Английский
Процитировано
2
Life, Год журнала: 2025, Номер 15(1), С. 126 - 126
Опубликована: Янв. 18, 2025
Post-translational modifications (PTMs) of proteins dynamically build the buffering and adapting interface between oncogenic mutations environmental stressors, on one hand, cancer cell structure, functioning, behavior. Aberrant PTMs can be considered as enabling characteristics long they orchestrate all malignant variability in proteome cells, cancer-associated tumor microenvironment (TME). On other enhance anticancer mechanisms tumoral ecosystem or sustain beneficial effects oncologic therapies through degradation inactivation carcinogenic or/and activation tumor-suppressor proteins. In this review, we summarized analyzed a wide spectrum involved regulatory that drive tumorigenesis, genetic instability, epigenetic reprogramming, events metastatic cascade, cytoskeleton extracellular matrix (ECM) remodeling, angiogenesis, immune response, tumor-associated microbiome, metabolism rewiring most important hallmarks cancer. All develop due to proteins, which modulate gene transcription, intracellular signaling, protein size, activity, stability localization, trafficking, secretion, half-life, protein–protein interactions (PPIs). associated with exploited better understand underlying molecular heterogeneous chameleonic disease, find new biomarkers progression prognosis, personalize oncotherapies, discover targets for drug development.
Язык: Английский
Процитировано
2
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(9), С. 13646 - 13659
Опубликована: Фев. 18, 2025
Antimicrobial peptides (AMPs) represent a promising strategy for combating antibiotic-resistant bacterial infections; however, their therapeutic application remains limited by high toxicity and poor stability. In this study, we designed class of core-shell nanoparticles through the self-assembly an imperfectly amphipathic peptide, with fatty acids varying chain lengths acting as stabilizing agents. The lead nanoparticle, designated GV2, demonstrated superior antibacterial efficacy, safety, stability compared to its nonassembled peptide form. GV2 exhibited rapid bactericidal effect potent activity against both planktonic biofilm-associated bacteria, no observed development resistance. Mechanistic investigations revealed that permeabilized ruptured membranes targeting three major components in membrane including lipopolysaccharide (LPS), lipoteichoic acid (LTA), phosphatidylglycerol (PG). Notably, effectively protected skin wound infections context, highlighting clinical potential. This study not only presents antimicrobial candidate but also provides strategic framework rational design stable safe AMPs.
Язык: Английский
Процитировано
2
Frontiers in Oncology, Год журнала: 2023, Номер 13
Опубликована: Сен. 19, 2023
Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching modified chemical group to some its amino acid residues. PTMs modulate essential physiological processes such as signal transduction, metabolism, localization, and turnover have clinical relevance in cancer age-related pathologies. Majority proteins undergo post-translational modifications, irrespective their occurrence or after biosynthesis. link termini side chains, causing backbone get cleaved, spliced, cyclized, name few. These expand diversity proteome regulate activity, structure, locations, functions, protein-protein interactions (PPIs). This ability modify physical functions render vital. To date, over 200 different been reported, owing advanced detection technologies. Some these include phosphorylation, glycosylation, methylation, acetylation, ubiquitination. Here, we discuss about existing well novel with implications aberrant states, which will help us better understand sites effect on core biological progression cancer.
Язык: Английский
Процитировано
24