The immunology of diabetic cardiomyopathy DOI Creative Commons

Ming Song,

Honggang Dai,

Quan Zhou

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Апрель 7, 2025

Diabetic cardiomyopathy is a notable microvascular complication of diabetes, characterized primarily by myocardial fibrosis and functional abnormalities. Long-term hyperglycemia induces excessive activation recruitment immune cells triggers the cascade inflammatory responses, resulting in systemic local cardiac inflammation. Emerging evidence highlights significant roles immunology modulating pathology diabetic cardiomyopathy. As primary effectors reactions, are consistently present tissue can be recruited under pathological circumstances. A disproportionate favor to proinflammatory types increased cytokine levels mediate fibroblast proliferation, phenotypic transformation, collagen synthesis ultimately rise hypertrophy. Meanwhile, severity also strongly associated with diverse phenotypes alterations cells, including macrophages, dendritic mast neutrophils, natural killer innate immunity CD4+ T lymphocytes, CD8+ B lymphocytes adaptive immunity. In this review, we synthesized current analysis critical role played system its components progression Finally, highlight preclinical clinical targeting strategies translational implications.

Язык: Английский

Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: molecular mechanisms and targeted therapies DOI Creative Commons

Pinglian Yang,

X. Rong,

Zhuo Gao

и другие.

Pharmacological Research, Год журнала: 2025, Номер 212, С. 107588 - 107588

Опубликована: Янв. 7, 2025

Atherosclerosis, a multifactorial progressive inflammatory disease, is the common pathology underlying cardiovascular and cerebrovascular diseases. The macrophage plasticity involved in pathogenesis of atherosclerosis. With advance metabolomics epigenetics, metabolites/metabolic epigenetic modification such as DNA methylation, histone noncoding RNA, play crucial role polarization progression Herein, we provide comprehensive review essential metabolic regulation, well crosstalk between two regulating We also highlight potential therapeutic strategies via modifications for atherosclerosis, offer recommendations to our knowledge roles metabolic-epigenetic context Fundamental studies that elucidate mechanisms by which regulation influence atherosclerosis will pave way novel approaches.

Язык: Английский

Процитировано

2
The role of M1/M2 macrophage polarization in the pathogenesis of obesity-related kidney disease and related pathologies DOI Creative Commons

Periklis Dousdampanis,

Ιωάννα Αγγελετοπούλου, Αthanasia Mouzaki

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 10, 2025

Obesity is a rapidly growing health problem worldwide, affecting both adults and children increasing the risk of chronic diseases such as type 2 diabetes, hypertension cardiovascular disease (CVD). In addition, obesity closely linked to kidney (CKD) by either exacerbating diabetic complications or directly causing damage. Obesity-related CKD characterized proteinuria, lipid accumulation, fibrosis glomerulosclerosis, which can gradually impair function. Among immune cells innate adaptive response involved in pathogenesis obesity-related diseases, macrophages play crucial role inflammation associated with CKD. obese individuals, enter pro-inflammatory state known M1 polarization, contributes inflammation. This polarization promotes tissue damage, fibrosis, leading progressive loss macrophage-induced oxidative stress key feature it also cell damage Macrophages contribute insulin resistance diabetes releasing inflammatory molecules that glucose metabolism, complicating management patients. Hypertension atherosclerosis, are often obesity, progression via pathways. influence blood pressure regulation vascular inflammation, particularly renin-angiotensin system. accumulate arterial plaques, plaque instability, may increase CVD review focuses on involvement highlights their critical link between other pathologies. Targeting macrophage ensuing could be an effective therapeutic strategy for related improve outcomes patients disease.

Язык: Английский

Процитировано

1
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets DOI Creative Commons

Fan Guan,

Ruixuan Wang,

Zhenjie Yi

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 7, 2025

Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.

Язык: Английский

Процитировано

1
Mitochondrial Dynamics and Metabolism in Macrophages for Cardiovascular Disease: a review DOI

Yi-lang Zhong,

Chenqin Xu,

Ji Li

и другие.

Phytomedicine, Год журнала: 2025, Номер 140, С. 156620 - 156620

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

1
Ultrasmall Prussian Blue Nanozyme Attenuates Osteoarthritis by Scavenging Reactive Oxygen Species and Regulating Macrophage Phenotype DOI
Zhiguo Qin, Xiaofei Li, Peng Wang

и другие.

Nano Letters, Год журнала: 2024, Номер 24(37), С. 11697 - 11705

Опубликована: Сен. 3, 2024

Osteoarthritis (OA) is a degenerative joint disease characterized by obscure etiology and unsatisfactory therapeutic outcomes, making the development of new efficient therapies urgent. Superfluous reactive oxygen species (ROS) have historically been considered one crucial factors inducing pathological progression OA. Ultrasmall Prussian blue nanoparticles (USPBNPs), approximately sub-5 nm in size, are developed regulating configuration polyvinylpyrrolidone chains. USPBNPs display an excellent ROS eliminating capacity catalase-like activity, capable decomposing hydrogen peroxide (H

Язык: Английский

Процитировано

6
Is retinal vein occlusion highly associated with an increased risk of myocardial infarction? A systematic review and meta-analysis DOI Creative Commons
Kuo-Su Chen,

Hoi-Chun Chan,

Chi‐Ming Chan

и другие.

International Journal of Retina and Vitreous, Год журнала: 2024, Номер 10(1)

Опубликована: Ноя. 12, 2024

Retinal vein occlusion (RVO) and acute myocardial infarction (MI) are significant vascular events that impact patient health mortality. Both conditions share common risk factors, such as hypertension, diabetes, atherosclerosis. This study investigated the potential connection between RVO MI, particularly among younger individuals, to improve preventive measures management protocols.

Язык: Английский

Процитировано

6
Innovative Approaches to Boost Mesenchymal Stem Cells Efficacy in Myocardial Infarction Therapy DOI Creative Commons
Chuanfeng An, Yuan Zhao, Lipeng Guo

и другие.

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101476 - 101476

Опубликована: Янв. 9, 2025

Stem cell-based therapy has emerged as a promising approach for heart repair, potentially regenerating damaged tissue and improving outcomes patients with disease. However, the efficacy of stem therapies remains limited by several challenges, including poor cell survival, low retention rates, integration, functional outcomes. This article reviews current enhancement strategies to optimize mesenchymal cardiac repair. Key approaches include optimizing delivery methods, enhancing engraftment, promoting functions through genetic molecular modifications, paracrine effects cells, leveraging biomaterials engineering techniques. By focusing on these techniques, paper highlights innovative that can transform into more viable effective treatment option The ongoing research technological advancements continue push boundaries, hoping make mainstream

Язык: Английский

Процитировано

0
Protocol to generate a 3D atherogenesis-on-chip model for studying endothelial-macrophage crosstalk in atherogenesis DOI
K.J. Hanford, Kim E. Dzobo,

Miranda Versloot

и другие.

STAR Protocols, Год журнала: 2025, Номер 6(1), С. 103559 - 103559

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

0
Identifying Vascular Stiffening-Sensitive Macrophages Through Integration of SingleCell Transcriptomics and Imaging Flow Cytometry DOI Creative Commons
Jin Wang,

Jiyin Wang,

Yuting Zhang

и другие.

Biophysics Reports, Год журнала: 2025, Номер 0(0), С. 0 - 0

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Effects of aged garlic extract on macrophage functions: a short review of experimental evidence (Review) DOI Open Access

Kohei Karasaki

Biomedical Reports, Год журнала: 2025, Номер 22(3)

Опубликована: Янв. 15, 2025

Macrophages play crucial roles in both the innate and adaptive immune systems, contributing to removal of pathogens subsequent responses. Conversely, aberrant macrophage functions are associated with onset progression various diseases, highlighting macrophages as potential therapeutic targets. Aged garlic extract (AGE) is derived from that has undergone a maturation process over 10 months an ethanol solution contains variety bioactive components which produced aging process. Previous animal studies clinical trials have demonstrated AGE its constituents exert range health benefits, including modulation amelioration disease conditions. Experimental indicate modulates pathological To facilitate understanding AGE's functional alleviation for macrophage‑associated present short review summarizes experimental evidence supporting notion modify functions, phagocytosis, production reactive oxygen species polarization.

Язык: Английский

Процитировано

0