The immunology of diabetic cardiomyopathy DOI Creative Commons

Ming Song,

Honggang Dai,

Quan Zhou

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Апрель 7, 2025

Diabetic cardiomyopathy is a notable microvascular complication of diabetes, characterized primarily by myocardial fibrosis and functional abnormalities. Long-term hyperglycemia induces excessive activation recruitment immune cells triggers the cascade inflammatory responses, resulting in systemic local cardiac inflammation. Emerging evidence highlights significant roles immunology modulating pathology diabetic cardiomyopathy. As primary effectors reactions, are consistently present tissue can be recruited under pathological circumstances. A disproportionate favor to proinflammatory types increased cytokine levels mediate fibroblast proliferation, phenotypic transformation, collagen synthesis ultimately rise hypertrophy. Meanwhile, severity also strongly associated with diverse phenotypes alterations cells, including macrophages, dendritic mast neutrophils, natural killer innate immunity CD4+ T lymphocytes, CD8+ B lymphocytes adaptive immunity. In this review, we synthesized current analysis critical role played system its components progression Finally, highlight preclinical clinical targeting strategies translational implications.

Язык: Английский

Clinical translation of mesenchymal stem cells in ischemic heart failure: Challenges and future perspectives DOI Creative Commons

Anqi Guan,

Lisa Alibrandi,

Elika Verma

и другие.

Vascular Pharmacology, Год журнала: 2025, Номер unknown, С. 107491 - 107491

Опубликована: Март 1, 2025

Myocardial infarction (MI) with resulting congestive heart failure is one of the leading causes death worldwide. Current therapies for treating MI, such as devices, traditional medicine, and surgeries, come many limitations patients in their final stages have little chances experiencing any reversible changes. In recent decades, Mesenchymal stem cell (MSC) based therapy has become most popular rapidly developing fields MI. Their supremacy clinical applications partially due to unique properties encouraging pre-clinical outcomes various animal disease models. However, majority trials registered MSC diverse human diseases, including fallen short expectations. This review intends discuss advances application using MSCs cardiac repair challenges facing translation regeneration restoration endothelial-cardiomyocyte crosstalk, immunomodulation immune rejection, poor homing migration, well low retention survival. Furthermore, we will strategies being investigated help overcome some these challenges.

Язык: Английский

Процитировано

0
Cryptotanshinone alleviates vasculitis in Kawasaki disease by modulating macrophage-neutrophil interactions DOI Creative Commons

Lixin Zhao,

Jing Jin, Haiguo Yu

и другие.

Acta Materia Medica, Год журнала: 2025, Номер 4(2)

Опубликована: Янв. 1, 2025

Kawasaki disease (KD) is a form of vasculitis that affects primarily children and can lead to severe cardiovascular complications. Because current treatment options are often ineffective for some patients, new therapeutic strategies needed. Cryptotanshinone (CTS), compound derived from Salvia miltiorrhiza Bunge, has shown potential as an anti-inflammatory agent. Herein, in mouse model KD induced by Lactobacillus casei cell wall extract (LCWE), CTS was found significantly decrease inflammation the aortic root coronary arteries. This inhibited activation macrophages neutrophils, which critical contributors KD. Network pharmacology analysis suggested modulates chemokine signaling pathway, thereby inhibiting recruitment inflammatory cells preventing further progression. Single-nucleus RNA sequencing (snRNA-seq) revealed decreased macrophage numbers activity, particularly Ccl8, consequently neutrophil recruitment. Our findings suggest might provide promising option modulating immune interactions inflammation.

Язык: Английский

Процитировано

0
Transforming Growth Factor-β-mediated attenuation of cardio-renal oxidative stress, inflammation and fibrosis by L-arginine in fludrocortisone acetate induced-hypertensive rats DOI
Abhishek Biswas, Tushar Emran, Sabrin Islam Khan

и другие.

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177559 - 177559

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Autophagy and Its Association with Macrophages in Clonal Hematopoiesis Leading to Atherosclerosis DOI Open Access
Shuanhu Li, Xin Zhou,

Qinchun Duan

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3252 - 3252

Опубликована: Апрель 1, 2025

Atherosclerosis, a chronic inflammatory disease characterized by lipid accumulation and immune cell infiltration, is linked to plaque formation cardiovascular events. While traditionally associated with metabolism endothelial dysfunction, recent research highlights the roles of autophagy clonal hematopoiesis (CH) in its pathogenesis. Autophagy, cellular process crucial for degrading damaged components, regulates macrophage homeostasis inflammation, both which are pivotal atherosclerosis. In macrophages, influences metabolism, cytokine regulation, oxidative stress, helping prevent instability. Defective exacerbates impairs cholesterol efflux, accelerates progression. Additionally, autophagic processes cells smooth muscle further contribute atherosclerotic pathology. Recent studies also emphasize interplay between CH, wherein somatic mutations genes like TET2, JAK2, DNMT3A drive expansion enhance responses plaques. These modify function, intensifying environment accelerating Chaperone-mediated (CMA), selective form autophagy, plays critical role regulating inflammation pro-inflammatory cytokines oxidized low-density lipoprotein (ox-LDL). Impaired CMA activity leads these substrates, activating NLRP3 inflammasome worsening inflammation. Preclinical suggest that pharmacologically may mitigate atherosclerosis animal models, reduced instability increases This review importance regulation focusing on formation, contributions CH. Building upon current advances, we propose hypothesis programmed death, intrinsic axis modulates fundamental functions playing complex development Understanding mechanisms offers potential therapeutic strategies targeting reduce burden disease.

Язык: Английский

Процитировано

0
The immunology of diabetic cardiomyopathy DOI Creative Commons

Ming Song,

Honggang Dai,

Quan Zhou

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Апрель 7, 2025

Diabetic cardiomyopathy is a notable microvascular complication of diabetes, characterized primarily by myocardial fibrosis and functional abnormalities. Long-term hyperglycemia induces excessive activation recruitment immune cells triggers the cascade inflammatory responses, resulting in systemic local cardiac inflammation. Emerging evidence highlights significant roles immunology modulating pathology diabetic cardiomyopathy. As primary effectors reactions, are consistently present tissue can be recruited under pathological circumstances. A disproportionate favor to proinflammatory types increased cytokine levels mediate fibroblast proliferation, phenotypic transformation, collagen synthesis ultimately rise hypertrophy. Meanwhile, severity also strongly associated with diverse phenotypes alterations cells, including macrophages, dendritic mast neutrophils, natural killer innate immunity CD4+ T lymphocytes, CD8+ B lymphocytes adaptive immunity. In this review, we synthesized current analysis critical role played system its components progression Finally, highlight preclinical clinical targeting strategies translational implications.

Язык: Английский

Процитировано

0