Ultra-short lipopeptides containing D-amino acid exhibiting excellent stability and antibacterial activity against Gram-positive bacteria

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117341 - 117341

Опубликована: Фев. 1, 2025

Язык: Английский

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Designing Effective Antimicrobial Agents: Structural Insights into the Antibiofilm Activity of Ionic Liquids

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Research concerning biofilm control is critical due to the pervasive and resilient nature of biofilms, which pose significant challenges across industrial, environmental, healthcare sectors. Traditional antimicrobial treatments are often ineffective against these robust structures. Here, we explore properties ionic liquids (ILs) their efficacy in disruption. By examining structural variations ILs, highlight key role hydrophobicity, noting that longer alkyl side chains IL cations enhance disruption bacterial death. However, upon reaching a certain optimal chain length─usually C12 C14─the activity ILs starts decrease. Furthermore, symmetry size anions significantly impact elimination. This Perspective addresses gap research, revealing structure–activity relationships providing foundation for designing more effective biofilm-disrupting agents.

Язык: Английский

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What Is the Impact of Antibiotic Resistance Determinants on the Bacterial Death Rate?

Antibiotics, Год журнала: 2025, Номер 14(2), С. 201 - 201

Опубликована: Фев. 14, 2025

Objectives: Antibiotic-resistant bacteria are widespread, with resistance arising from chromosomal mutations and genes located in the chromosome or mobile genetic elements. While determinants often reduce bacterial growth rates, their influence on death under bactericidal antibiotics remains poorly understood. When exposed to which they susceptible, typically undergo a two-phase decline: fast initial exponentially decaying phase, followed by persistent slow-decaying phase. This study examined how affect rates during both phases. Methods: We analyzed of ampicillin-exposed Escherichia coli populations strains sensitive ampicillin but resistant nalidixic acid, rifampicin, both, carrying conjugative plasmids RN3 R702. Results: Single mutants acid rifampicin decayed faster than cells early whereas double-resistant mutant exhibited prolonged survival. These contrasting impacts suggest epistatic interactions between mutations. Persistent-phase for did not differ significantly wild-type cells. In contrast, plasmid-carrying displayed distinct dynamics: R702 plasmid-bearing showed higher persistent-phase plasmid-free cells, while lower rates. Conclusions: Bactericidal may kill other more effectively Moreover, epistasis occur when different same cell, impacting potential antibiotic choice. results have significant implications optimizing eradication protocols clinical settings, as well animal health industrial food safety management.

Язык: Английский

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Unravelling the Antibiotic Resistance: Molecular Insights and Combating Therapies

Applied Biochemistry and Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

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Deciphering meropenem persistence in Acinetobacter baumannii facilitates discovery of anti-persister activity of thymol

Antimicrobial Agents and Chemotherapy, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

ABSTRACT Decades of antibiotic misuse have accelerated the emergence multi- and extensively drug-resistant bacteria. Bacterial pathogens employ several strategies such as resistance, tolerance, biofilm formation in response to extreme environments stress. Another crucial survival mechanism involves stochastic generation bacterial subpopulations known persisters, which can endure high concentrations antibiotics. Upon removal stress, these revert back their original phenotype links them relapse recalcitrance chronic infections, a significant problem clinical settings. Persistent infections are particularly notable Acinetobacter baumannii , top-priority ESKAPE pathogen, where carbapenems serve last-resort Several reports indicate rising therapeutic failure due persistence, underscoring importance developing anti-persister therapeutics. In this study, we explored mechanisms transient persister A. against meropenem. Our investigation revealed changes membrane properties energetics meropenem persisters including noteworthy increase tolerance other This understanding guided evaluation an in-house collection GRAS status compounds for potential activity. The compound thymol demonstrated remarkable inhibitory activity pathogens. Further its impact on cell physiology, efflux pump inhibition disruption cellular respiration. Given our results, propose compelling strategy could be employed either monotherapy or combination with

Язык: Английский

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Cross-Talk Between Signal Transduction Systems and Metabolic Networks in Bacterial Antibiotics Resistance and Tolerance

International Journal of Antimicrobial Agents, Год журнала: 2025, Номер unknown, С. 107479 - 107479

Опубликована: Фев. 1, 2025

Язык: Английский

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Pathogen-derived glyoxylate inhibits Tet2 DNA dioxygenase to facilitate bacterial persister formation

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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The Role of Phenotypic Plasticity and Within‐Environment Trait Variability in the Assembly of the Nectar Microbiome and Plant–Microbe–Animal Interactions

Ecology and Evolution, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

ABSTRACT The study of the rules that govern relationship between phenotypic plasticity, genetic structure, and ecological success has traditionally focused on animals, plants, a few model microbial species, whereas non‐model microorganisms have received much less attention in this regard. floral nectar angiosperms is an ephemeral, island‐like habitat for different highly adapted yeasts bacteria. growth depends their ability to efficiently use available nutrients tolerate challenging physicochemical conditions, including high osmotic pressures, unbalanced carbon‐to‐nitrogen ratios, presence diverse defensive compounds plant origin. production alternative states response environmental cues (i.e., plasticity) or independently from these (within‐environment trait variability) might be particularly relevant nectar, which rapid needed population persistence improve chance animal‐mediated dispersal. In article, we microbiome as example encourage further research causes consequences plasticity within‐environment variability microbes. We review previous work mechanisms potential significance displayed by Additionally, provide overview some topics require attention, trade‐offs traits are adaptation dynamic environments direct indirect effects fitness flower‐visiting other conclude microbes essential get better understanding community assembly establishment interactions similar strongly selective habitats.

Язык: Английский

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Antibacterial and anti-biofilm activities of Derazantinib (ARQ-087) against Staphylococcus aureus

Archives of Microbiology, Год журнала: 2025, Номер 207(4)

Опубликована: Март 6, 2025

Язык: Английский

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Different aspects of Pseudomonas aeruginosa biofilm: an in-depth analysis from formation to detection

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

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