Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 26, 2025
Body
mass
index
(BMI)
is
important
for
predicting
the
occurrence
of
metabolic
abnormality,
but
sex
differences
exist.
We
aimed
to
investigate
potential
in
predictive
value
BMI
abnormality
and
calculate
optimal
cut-offs
each
sex.
Participants
(n
=
4,623)
who
attended
a
health
check-up
centre
continuously
Eastern
China
between
January
2022
December
2023
were
evaluated
abnormalities.
calculated
proportions
different
abnormalities
sexes.
Receiver
operating
characteristic
(ROC)
curves
determine
cut-off
values
males
females.
The
recognition
rate
using
men
women
evaluated.
Among
4,623
participants
(2,234
2,389
women),
age-adjusted
prevalence
all
was
significantly
greater
among
than
females
(p
<
0.001).
23.5
kg/m2
(males)
21.8
(females).
When
≥24
used
as
rates
abnormal
factor
male
group
above
50%,
while
they
mostly
below
50%
female
group,
except
hyperglycaemia
hypertriglyceridemia.
However,
females,
when
≥22
value,
that
There
thresholds
population.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 23, 2025
Previous
studies
have
indicated
an
association
between
UHR
and
diabetes
risk,
but
evidence
from
large-scale
diverse
populations
remains
limited.
This
study
aims
to
verify
UHR’s
independent
role
in
risk
prediction
a
large
sample
population
assess
its
applicability
across
different
populations.
We
drew
upon
data
30,813
participants
collected
during
the
2005–2018
NHANES
cycle.
The
of
was
explored
using
multivariate
logistic
regression
models,
with
key
predictive
factors
identified
through
LASSO
regression.
Model
effectiveness
evaluated
receiver
operating
characteristic
(ROC)
curves,
decision
curve
analysis
(DCA),
calibration
metrics.
Additionally,
restricted
cubic
spline
(RCS)
threshold
effect
assessments
were
applied
examine
nonlinear
risk.
results
showed
that
levels
notably
elevated
individuals
when
compared
those
without
(
p
<
0.001).
occurrence
marked
increase
ascending
quartiles
(6.63%,
10.88%,
14.15%,
18.02%;
Results
strongly
linked
heightened
diabetes;
highest
quartile
found
nearly
four
times
lowest
(OR
=
4.063,
95%
CI:
3.536–4.669,
Subgroup
analyses
demonstrated
more
pronounced
females.
Key
variables
selected
via
improved
model’s
performance.
Restricted
inflection
point
at
10;
beyond
this
point,
accelerated,
exceeded
18,
increased
significantly
>
1).
ROC
baseline
model
(M1)
had
area
under
(AUC)
0.797,
while
multivariable
(M4)
after
selection
AUC
0.789.
Decision
curves
validated
ability
consistency.
indicates
may
be
predictor
showing
positive
correlation
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 24, 2025
Aims
Hyperuricaemia
is
associated
with
the
development
of
Diabetic
kidney
disease
(DKD).
However,
mechanism
hyperuricaemia
causing
progression
DKD
remain
unclear.
Methods
This
a
single-centre
retrospective
study.
155
biopsy-proven
patients
were
grouped
into
and
non-hyperuricaemia
groups.
Kaplan-Meier
analysis
landmark
curves
performed
to
explore
predictors
end-stage
renal
(ESRD),
Cox
regression
was
used
screen
for
factors,
nomogram
constructed
predict
prognosis
DKD.
Results
Patients
in
group
had
higher
serum
creatinine
(Scr),
degree
mesangial
expansion
IFTA
score
lower
GFR,
haemoglobin.
SUA
level
positively
correlated
scores.
The
curve
revealed
worse
survival
group,
especially
after
12
months.
11
variables,
including
age,
sex,
haemoglobin,
Scr,
SUA,
pathological
collected
make
model.
In
testing
training
sets,
AUCs
at
1,
3,
5
years
0.888,
0.939,
0.886
0.947,
0.867,
0.905,
respectively.
Conclusion
clinicopathologic
manifestation
much
more
severe,
predicted
prognosis.
A
new
prediction
model
accuracy.
Molecular Ecology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
ABSTRACT
Cetaceans
show
remarkable
diversity
in
diving
capability,
implying
a
range
of
adaptive
strategies
to
hazards
such
as
hydrostatic
pressure
and
oxidative
stress,
but
few
studies
have
considered
the
evolution
extreme
diving.
Here,
we
first
examined
relationship
between
morphological
physiological
factors
capability
then
molecular
candidate
deep‐sea
traits
genomic
dataset
cetaceans.
Our
included
six
super‐divers,
sperm
whales
(families
Physeteridae
Kogiidae)
beaked
(Ziphiidae),
species
that
can
dive
deeper
than
1000
m
for
about
an
hour
or
longer.
We
found
positive
association
oxygen‐linked
globins,
super‐diver
myoglobin
(
MB
)
is
under
selection
harbours
reported
functional
amino
acid
change.
Blubber
thickness
was
positively
associated,
likely
provide
thermal
insulation
resistance.
Super‐divers
gene
changes
may
contribute
differences
composition
outer
blubber
neutral
lipids
(triacylglycerols
wax
esters),
fatty
acids
cholesterol.
Total
lung
capacity
relative
body
mass
showed
negative
association,
ostensibly
limit
gas
bubbles
cause
decompression
sickness.
A
assay
suggests
ATP8B1
substitution
reduce
injury
super‐divers.
Super‐diver
XDH
has
two
unique
decreased
ability
produce
uric
hypoxia
when
its
ROS‐generating
XO
isoform
prevalent,
suggesting
it
reduces
cell
damage
from
stress
accumulation
with
prolonged
dives.
study
deepens
understanding
how
emerged
cetacean
lineage.
Preventive Medicine Reports,
Год журнала:
2025,
Номер
51, С. 103000 - 103000
Опубликована: Фев. 10, 2025
The
pathophysiological
mechanisms
underlying
hyperuricemia
necessitate
the
identification
of
contributing
factors
to
better
understand
disease
progression
and
develop
effective
therapies.
This
study
aimed
investigate
association
between
Magnesium
Depletion
Score
(MDS)
hyperuricemia.
A
cross-sectional
was
sourced
from
National
Health
Nutrition
Examination
Survey
2003-2018.
Hyperuricemia
defined
by
serum
uric
acid
levels.
MDS
calculated
incorporating
affecting
renal
magnesium
reabsorption.Weighted
multivariable
logistic
regression
employed
assess
hyperuricemia,
with
sensitivity
analyses
confirm
robustness.
Additionally,
Restricted
Cubic
Spline
(RCS)
Receiver
Operating
Characteristic
(ROC)
curve
were
used
further
elucidate
relationship.
Compared
low
group
(0-1),
odds
ratios
(OR)
95
%
confidence
intervals
(CI)
for
middle
(2)
high
(3-5)
1.76
(1.52-2.04),
3.14(2.54-3.88),
respectively.
RCS
analysis
illustrated
a
linear
dose-response
relationship
ROC
demonstrated
that
had
an
area
under
0.720
(95
CI,
0.717-0.721).
highlights
strong
risk,
emphasizing
importance
addressing
deficiency
in
hyperuricemic
patients.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 13, 2025
Background
Helicobacter
pylori
(Hp)
infection
is
one
of
the
major
global
health
problems
resulting
in
multiple
system
disorders.
The
serum
uric
acid
to
high
density
lipoprotein
cholesterol
ratio
(UHR)
a
novel
index
inflammation
and
metabolism,
but
its
association
with
development
Hp
still
unclear.
Materials
methods
This
cross-sectional
study
involving
2,666
participants,
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
United
States.
relationship
between
UHR
was
evaluated
by
multivariate
logistic
regression
sensitivity
analysis
enhance
stability
results.
Results
Among
all
individuals,
1,165
were
positive
(43.7%)
1,501
negative
(56.3%).
After
adjustment,
there
correlation
(OR
=
1.15;
95%
CI
1.02–1.30;
P
0.020).
relatively
stable
subgroup
(
>
0.05).
Conclusion
There
our
study.
non-invasive
indicator
can
improve
ability
monitor
may
find
alternative
therapeutic
intervention
targets.
