Cytokine & Growth Factor Reviews, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Sonodynamic therapy (SDT), which is non-invasive and controllable has the potential to treat triple-negative breast cancer (TNBC). However, hypoxia immunosuppressive tumor microenvironment (TME) often block production of reactive oxygen species induction SDT-activated immunogenic cell death, thus limiting activation adaptive immune responses. To alleviate these challenges, we proposed development a multifunctional biomimetic nanoplatform (mTSeIR), was designed with diselenide-conjugated sonosensitizers tirapazamine (TPZ), encapsulated within M1 macrophage membrane. This utilized hypoxia-induced chemotherapy improve efficacy SDT, further enhance immunotherapy by activating innate immunity remodeling TME. Firstly, prodrug TPZ activated due increased consumption associated SDT. Subsequently, mTSeIR enhanced repolarization M2 macrophages phenotype. The diselenide component in effectively natural killer cell-mediated antitumor response. Ultimately, vivo studies indicated that mTSeIR+US good biosafety achieved over 98% inhibition immunotherapy. research presents an efficient approach addressed limitations SDT achieves simultaneous both immunotherapy, resulting significant anti-metastatic TNBC.
Язык: Английский
Процитировано
1
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Март 3, 2025
Abstract Adoptive transfer of chimeric antigen receptor (CAR)-modified natural killer (NK) cells represents a transformative approach that has significantly advanced clinical outcomes in patients with malignant hematological conditions. However, the efficacy CAR-NK treating solid tumors is limited by their exhaustion, impaired infiltration and poor persistence immunosuppressive tumor microenvironment (TME). As NK cell functional states are associated IL-2 cascade, we engineered mesothelin-specific secrete neoleukin-2/15 (Neo-2/15), an IL-2Rβγ agonist, to resist polarization within TME. The adoptively transferred Neo-2/15-armored exhibited enhanced cytotoxicity, less exhaustion longer TME, thereby having superior antitumor activity against pancreatic cancer ovarian cancer. Mechanistically, Neo-2/15 provided sustained downstream signaling, which promotes expression c-Myc nuclear respiratory factor 1 (NRF1) cells. This upregulation was crucial for maintaining mitochondrial adaptability metabolic resilience, ultimately leading increased cytotoxicity pronounced resistance TME necessitated NRF1, essential augmentative effects elicited Neo-2/15. Overexpression NRF1 bolsters both vitro vivo, ATP production. Collectively, Neo-2/15-expressing exerts exhaustion-resistance survival tumors.
Язык: Английский
Процитировано
1
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 1013 - 1032
Опубликована: Янв. 1, 2025
Background: Sepsis is a severe complication in leukemia patients, contributing to high mortality rates.Identifying early predictors of sepsis crucial for timely intervention.This study aimed develop and validate predictive model risk patients using machine learning techniques.Methods: This retrospective included 4310 admitted the Affiliated Hospital Guangdong Medical University from 2005 2024, 70% training 30% validation.Feature selection was performed univariate logistic regression, LASSO, Boruta algorithm, followed by multivariate regression analysis.Seven models were constructed evaluated receiver operating characteristic (ROC) curves decision curve analysis (DCA).Shapley additive explanations (SHAP) applied interpret results, restricted cubic spline (RCS) explored nonlinear relationships between variables risk.Furthermore, we examined interactions among better understand their potential interrelationships.Results: The random forest (RF) outperformed all others, achieving an AUC 0.765 cohort 0.700 validation cohort.Key identified SHAP C-reactive protein (CRP), procalcitonin (PCT), neutrophil count (Neut), lymphocyte (Lymph), thrombin time (TT), red blood cell (RBC), total bile acid (TBA), systolic pressure (SBP).RCS revealed significant non-linear associations CPR, PCT, Neut, Lymph, TT, RBC SBP with risk.Pairwise correlation further these variables. Conclusion:The RF exhibited robust power providing clinicians valuable tool assessment optimization treatment strategies.
Язык: Английский
Процитировано
0
Clinical Immunology, Год журнала: 2025, Номер 275, С. 110486 - 110486
Опубликована: Март 20, 2025
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(7), С. 488 - 488
Опубликована: Март 25, 2025
Inflammation is an essential component of the immune response that protects host against pathogens and facilitates tissue repair. Chronic inflammation a critical factor in cancer development progression. It affects every stage tumor development, from initiation promotion to invasion metastasis. Tumors often create inflammatory microenvironment induces angiogenesis, suppression, malignant growth. Immune cells within interact actively with cells, which drives progression through complex molecular mechanisms. triggered by factors such as infections, obesity, environmental toxins strongly linked increased risk. However, acute responses can sometimes boost antitumor immunity; thus, presents both challenges opportunities for therapeutic intervention. This review examines how contributes biology, emphasizing its dual role tumorigenesis potential target.
Язык: Английский
Процитировано
0
Molecular Immunology, Год журнала: 2025, Номер 182, С. 54 - 61
Опубликована: Апрель 4, 2025
Natural Killer (NK) cells are a vital element of the innate immune system, and NK cell-based therapies have demonstrated efficacy against various malignancies. However, targeting solid tumors has been challenging due to low infiltration into effective evasion strategies employed by tumors. Recent studies shown that cell derived nanovesicles (NK-NV) can not only replicate functions but also offer more advantages in clinical applications. They capable transporting cellular components such as proteins, nucleic acids, lipids across distances, thereby facilitating intercellular communication among within tumor microenvironment (TME). With progress nanomedical technology, these vesicles be engineered carry range functional elements therapeutic agents enhance their antitumoral capabilities. In this review, we summarize current available literature on NK-NVs, discuss potential biological role non-coding RNAs (ncRNAs), explore application treatment
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Апрель 8, 2025
This study conducted a novel systematic bibliometric and visualization analysis of global literature on immunotherapy for endometrial cancer (EC) to explore dynamic trends, research hotspots, emerging topics, providing valuable references future research. Articles reviews EC published between 2012 August 2024 were retrieved from the Web Science Core Collection (WoSCC). Bibliometric tools, CiteSpace VOSviewer, used analyze clustering patterns dynamics. A total 861 articles contributed by 5,331 authors 1,392 institutions across 58 countries or regions, involving 1,823 keywords. China demonstrated outstanding performance in this field, contributing over 40% publications ranking first publication volume. However, citation counts lags that United States, highlighting latter's leading position areas further improvement China's efforts. The University Texas Medical Anderson Cancer Center Nanjing two with highest number publications. In terms authorship, teams led Bosse, Tjalling, Creutzberg, Carien L made significant contributions advancing field. Among individual publications, work Talhouk et al. achieved average annual count 70.88, demonstrating its profound impact. journals, Gynecologic Oncology emerged as pivotal academic platform, publishing numerous achieving co-citation frequency. Additionally, Frontiers Oncology, Immunology, Genetics have become some most active rapidly developing journals recent years. Research hotspots are concentrated themes such "Tumor Immune Microenvironment", "Immune Checkpoint Inhibitors", "Targeted Therapy". Recent trends frontier focus combined application immune checkpoint inhibitors other therapies, nanotechnology immunotherapy, integration artificial intelligence enhance precision medicine. efforts increasingly directed toward various strategies basic clinical applications. comprehensive reveals rapid advancements potential immunotherapy. Strengthening international collaboration addressing barriers translation practice will drive progress promising
Язык: Английский
Процитировано
0
European Journal of Neuroscience, Год журнала: 2025, Номер 61(7)
Опубликована: Апрель 1, 2025
ABSTRACT The neuroinflammatory aspect of Alzheimer's disease ( AD ) has been largely focused on microglia, the innate immune cells brain; however, recent evidence increasingly points to importance multiple alterations in systemic response during development. Natural killer (NK) are also components immunity, whose role pathogenesis sporadically investigated and often conflicting results have reported. Recent clinical trial suggested potential beneficial effects immunotherapy based ex vivo–expanded, genetically unmodified, NK cells. This led increased interest understanding function these central nervous system both physiological pathological contexts such as . Considering that is predominantly a elderly population, this review, we summarized current state knowledge changes occur cell compartment normal aging process pathophysiological throughout continuum could potentially explain therapeutic efficacy
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Abstract Lymphoma, a common malignancy of the lymphatic system, presents considerable health challenges and imposes significant economic burden. Despite advancements in chemotherapy immunotherapy that have improved survival rates, issues such as high relapse rates treatment resistance remain pressing concerns. This study novel therapeutic strategy combines rituximab with vaccine for human B‐cell non‐Hodgkin lymphoma, evaluated humanized mouse model. combination therapy synergistically achieves superior tumor suppression prevention. By harnessing tumor‐killing efficacy monoclonal antibodies T cell‐mediated immunity elicited by vaccines, this approach represents promising advancement achieving significantly cancer outcomes.
Язык: Английский
Процитировано
0
Journal of Experimental & Clinical Cancer Research, Год журнала: 2025, Номер 44(1)
Опубликована: Апрель 25, 2025
Abstract This review discusses reprogramming the breast tumor immune microenvironment from an immunosuppressive cold state to immunologically active hot state. A complex interplay is revealed, in which accumulation of metabolic byproducts—such as lactate, reactive oxygen species (ROS), and ammonia—is shown impair T-cell function promote escape. It demonstrated that (TME) dominated by cytokines, including interleukin-10 (IL-10), transforming growth factorβ (TGFβ), IL-35. Notably, IL-35 produced regulatory T cells cancer cells. The conversion conventional into IL-35-producing induced cells, along with inhibition pro-inflammatory cytokine secretion, contributes suppression anti-tumor immunity. further key checkpoint molecules—such PD-1, PDL1, CTLA-4, TIM-3, LAG-3, TIGIT—are upregulated within TME, leading Tcell exhaustion diminished responses. blockade these checkpoints restore functionality proposed a strategy convert tumors ones robust effector cell infiltration. therapeutic potential chimeric antigen receptor (CAR)T therapy also explored, targeting specific tumor-associated antigens, such glycoproteins tyrosine kinases, highlighted. suggested CART efficacy can be enhanced combining inhibitors other immunomodulatory agents, thereby overcoming barriers imposed TME. Moreover, role microbiome regulating estrogen metabolism systemic inflammation reviewed. Alterations gut microbiota are affect microbiome-based interventions additional means facilitate cold-to-hot transition. concluded immunological pathways underpin suppression—through combination strategies involving blockade, therapies, modulation—the TME achieved. anticipated enhance infiltration function, improving overall immunotherapies better clinical outcomes for patients.
Язык: Английский
Процитировано
0