Neutrophils in Type 1 Diabetes: Untangling the Intricate Web of Pathways and Hypothesis DOI Creative Commons
Laura Nigi, E.A. Pedace, Francesco Dotta

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 505 - 505

Опубликована: Март 31, 2025

Neutrophils are increasingly recognized as key contributors to the pathogenesis of Type 1 Diabetes (T1D), yet their precise mechanistic role in disease onset and progression remains incompletely understood. While these innate immune cells reside pancreatic tissue support homeostasis under physiological conditions, they can also drive damage by triggering responses modulating inflammation. Within inflammatory milieu, neutrophils establish complex, bidirectional interactions with various cells, including macrophages, dendritic natural killer lymphocytes. Once activated, may enhance response through direct or indirect crosstalk antigen presentation, β-cell destruction dysfunction. These mechanisms underscore multifaceted dynamic T1D, shaped intricate immunological interactions. Further research into diverse functional capabilities is crucial for uncovering novel aspects involvement potentially revealing new therapeutic targets modulate progression.

Язык: Английский

Exploring Neutrophil Heterogeneity and Plasticity in Health and Disease DOI Creative Commons
Conny Gysemans,

Mateson Beya,

E.A. Pedace

и другие.

Biomedicines, Год журнала: 2025, Номер 13(3), С. 597 - 597

Опубликована: Март 1, 2025

Neutrophils, the most abundant polymorphonuclear leukocytes, are critical first responders to infection, and have historically been underappreciated in terms of their functional complexity within immune response. Once viewed primarily as short-lived, innate cells with limited plasticity, recent research has illuminated considerable heterogeneity diverse roles, which extend beyond involvement steady-state immunity. This review seeks provide an updated analysis neutrophil development, maturation, heterogeneity, a focus on how these characteristics influence modulation both healthy diseased tissues. Beginning origin neutrophils, we explore maturation into effector evolving roles defense under homeostatic disease-associated conditions. We then delve discussing breakthroughs that challenge traditional view neutrophils uniform population. address significant advances made identifying distinct subsets, emerging complexities challenges remain fully understanding diversity. Finally, highlight future directions opportunities for continued exploration this rapidly advancing field, shedding light insights could open new avenues therapeutic interventions.

Язык: Английский

Процитировано

1
Tumor-infiltrating myeloid cells; mechanisms, functional significance, and targeting in cancer therapy DOI Creative Commons
Fatemeh Sadat Toghraie, Maryam Bayat, Mahsa Sadat Hosseini

и другие.

Cellular Oncology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Tumor-infiltrating myeloid cells (TIMs), which encompass tumor-associated macrophages (TAMs), neutrophils (TANs), myeloid-derived suppressor (MDSCs), and dendritic (TADCs), are of great importance in tumor microenvironment (TME) integral to both pro- anti-tumor immunity. Nevertheless, the phenotypic heterogeneity functional plasticity TIMs have posed challenges fully understanding their complexity roles within TME. Emerging evidence suggested that presence is frequently linked prevention cancer treatment improvement patient outcomes survival. Given pivotal function TME, recently been recognized as critical targets for therapeutic approaches aimed at augmenting immunostimulatory cell populations while depleting or modifying those immunosuppressive. This review will explore important properties related immunity, angiogenesis, metastasis. We also document latest strategies targeting preclinical clinical settings. Our objective illustrate potential immunological may improve existing treatments.

Язык: Английский

Процитировано

0
Epidemiological and clinical characteristics of COVID-19 mortality: a retrospective study DOI Creative Commons
Yaohua Hu, You Lü, Jianzeng Dong

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 10, 2025

Background The global impact of SARS-CoV-2 and its associated coronavirus disease (COVID-19) has necessitated urgent characterization prognostic biomarkers. This study aimed to delineate the epidemiological clinical predictors mortality among hospitalized COVID-19 patients. Methods A retrospective cohort was conducted on 123 patients with laboratory-confirmed admitted Huoshenshan Hospital (Wuhan, China) from 1 February 2020 30 April 2020. Kaplan–Meier curve multivariate Cox regression were used assess independent factors survival time. Statistical significance set at a p -value <0.05. Results exhibited rate 49.6% (61/123), critical type (HR = 7.970, 0.009), leukocytosis 3.408, 0.006), lymphopenia 0.817, 0.038) emerging as reduced survival. Critical-type demonstrated significantly elevated inflammatory markers (neutrophils: 10.41 ± 6.23 × 10 9 /L; CRP: 104.47 29.18 mg/L) coagulopathy (D-dimer: 5.21 2.34 μg/ml) compared non-critical cases. Deceased pronounced metabolic derangements, including hyperglycemia (9.81 2.07 mmol/L) hepatic dysfunction (ALP: 174.03 30.13 U/L). Conclusion We revealed features different types summarized in this paper. found that type, leukocyte, lymphocyte are risk affect time, which could be an early helpful marker improve management

Язык: Английский

Процитировано

0
Inhibition of CD53 Reduces the Formation of ROS-Induced Neutrophil Extracellular Traps and Protects Against Inflammatory Injury in Acute Pancreatitis DOI Creative Commons
Tianqi Xia, Fei Han, Yaning Wang

и другие.

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3725 - 3739

Опубликована: Март 1, 2025

Background: The tetraspanin CD53 transmembrane protein is vital in immune cells like B and T cells, playing a crucial role various inflammatory conditions. However, its involvement neutrophils regarding inflammation remains uncertain. This study aims to examine the impact of on neutrophil extracellular traps (NETs) formation. Methods: Phorbol 12-myristate 13-acetate (PMA) was utilized establish an vitro classical NETs model investigate influence formation regulatory mechanisms. Subsequently, link between acute pancreatitis (AP), aseptic responses connected NETs, verified. Peripheral blood from clinical AP patients were collected explore AP, while mouse induced by caerulein employed confirm inhibition mice pancreatic tissue. Results: Our has shown that significantly elevated models patients. expression closely related prognosis At same time, neutralizing antibody (Anti-CD53) can inhibit vitro, injury damaged tissues. Mechanistically, modulate PI3K/AKT pathway promote NETs. Finally, targeted regulation effectively reduce tissues mice. Conclusion: results this mark first confirmation plays Targeting could potentially serve as novel therapeutic approach for treatment AP. Keywords: CD53, traps, pancreatitis,

Язык: Английский

Процитировано

0
Neutrophils: a Central Point of Interaction Between Immune Cells and Nonimmune Cells in Rheumatoid Arthritis DOI
Zhaoran Wang, Yi Jiao,

Wenya Diao

и другие.

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Март 28, 2025

Язык: Английский

Процитировано

0
Neutrophils in Type 1 Diabetes: Untangling the Intricate Web of Pathways and Hypothesis DOI Creative Commons
Laura Nigi, E.A. Pedace, Francesco Dotta

и другие.

Biomolecules, Год журнала: 2025, Номер 15(4), С. 505 - 505

Опубликована: Март 31, 2025

Neutrophils are increasingly recognized as key contributors to the pathogenesis of Type 1 Diabetes (T1D), yet their precise mechanistic role in disease onset and progression remains incompletely understood. While these innate immune cells reside pancreatic tissue support homeostasis under physiological conditions, they can also drive damage by triggering responses modulating inflammation. Within inflammatory milieu, neutrophils establish complex, bidirectional interactions with various cells, including macrophages, dendritic natural killer lymphocytes. Once activated, may enhance response through direct or indirect crosstalk antigen presentation, β-cell destruction dysfunction. These mechanisms underscore multifaceted dynamic T1D, shaped intricate immunological interactions. Further research into diverse functional capabilities is crucial for uncovering novel aspects involvement potentially revealing new therapeutic targets modulate progression.

Язык: Английский

Процитировано

0