The epidemiology, etiology, and future prophylactic options for cancers in Mainland China DOI Creative Commons
Hongsen Chen, Jie Xu, Wenbin Liu

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Май 28, 2025

Mainland China accounts for 18.66% of the world’s population, 24.17% global cancer new cases, and 26.44% cancer-related death worldwide in 2022. We aim to characterize spatiotemporal distribution patterns burden, elucidate main causes high propose evidence-based strategies prevention control major types China. conducted a systematic search relevant articles PubMed CNKI. also analyzed related data from two key databases: 2022 dataset International Agency Research on Cancer (IARC) records China’s National Mortality Surveillance System (from 2004 - 2018). Lung cancer, primary liver (PLC), gastric colorectal (CRC), esophageal accounted 67.50% all deaths. Age-standardized incidence rates (ASIR) mortality (ASMR) PLC, showed downward trends, while their crude kept increasing. The ASMR lung decreasing urban but increasing rural populations. burden CRC Increase could be attributed co-existence poverty-related risk factors like chronic infections affluence-related ones metabolic disorders. Primary targeting these modifiable is cost-effective. Aerobic exercise decrease occurrence via systemic low-grade inflammation. second tertiary prophylactic options should epidemiologically optimized. Targeting co-existed during economic transformation cost-effective strategy transforming countries.

Язык: Английский

Tailoring CAR surface density and dynamics to improve CAR-T cell therapy DOI Creative Commons

Ana Hinckley-Boned,

Carmen Barbero-Jiménez,

María Tristán‐Manzano

и другие.

Journal for ImmunoTherapy of Cancer, Год журнала: 2025, Номер 13(4), С. e010702 - e010702

Опубликована: Апрель 1, 2025

Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the treatment landscape for relapsed and/or refractory B-cell neoplasms, garnering Food and Drug Administration/European Medicines Agency approval six commercial products. Despite this success, challenges persist, including a relapse rate of 30–50% in hematologic tumors, limited clinical efficacy solid severe side effects. This review addresses critical need therapeutic enhancement by focusing on often-overlooked strategy modulating CAR protein density membrane. We delve into key factors influencing surface expression, such as downmodulation following encounter antigen-related factors. The dynamics remain underexplored; however, recent data point to its modification useful tool improving functionality. Notably, transcriptional control expression incorporation specific elements design have emerged interesting strategies tailor profiles. Therefore, controlling dynamic may represent an attractive achieving optimal outcomes.

Язык: Английский

Процитировано

0
The epidemiology, etiology, and future prophylactic options for cancers in Mainland China DOI Creative Commons
Hongsen Chen, Jie Xu, Wenbin Liu

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Май 28, 2025

Mainland China accounts for 18.66% of the world’s population, 24.17% global cancer new cases, and 26.44% cancer-related death worldwide in 2022. We aim to characterize spatiotemporal distribution patterns burden, elucidate main causes high propose evidence-based strategies prevention control major types China. conducted a systematic search relevant articles PubMed CNKI. also analyzed related data from two key databases: 2022 dataset International Agency Research on Cancer (IARC) records China’s National Mortality Surveillance System (from 2004 - 2018). Lung cancer, primary liver (PLC), gastric colorectal (CRC), esophageal accounted 67.50% all deaths. Age-standardized incidence rates (ASIR) mortality (ASMR) PLC, showed downward trends, while their crude kept increasing. The ASMR lung decreasing urban but increasing rural populations. burden CRC Increase could be attributed co-existence poverty-related risk factors like chronic infections affluence-related ones metabolic disorders. Primary targeting these modifiable is cost-effective. Aerobic exercise decrease occurrence via systemic low-grade inflammation. second tertiary prophylactic options should epidemiologically optimized. Targeting co-existed during economic transformation cost-effective strategy transforming countries.

Язык: Английский

Процитировано

0