Targeting the gut microbiota-inflammation-brain axis as a potential therapeutic strategy for psychiatric disorders: A Mendelian randomization analysis

Journal of Affective Disorders, Год журнала: 2025, Номер 374, С. 150 - 159

Опубликована: Янв. 13, 2025

Язык: Английский

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Gut microbiota metabolites, secretory immunoglobulin A and Bayley-III cognitive scores in children from the CHILD Cohort Study.

Brain Behavior & Immunity - Health, Год журнала: 2025, Номер 44, С. 100946 - 100946

Опубликована: Янв. 15, 2025

Язык: Английский

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Gut dysbiosis as a driver of neuroinflammation in attention-deficit/hyperactivity disorder: A review of current evidence

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

There is mounting evidence for the involvement of immune system, neuroinflammation and disturbed gut microbiota, or dysbiosis, in attentive-deficit/hyperactivity disorder (ADHD). Gut dysbiosis strongly implicated many physical, autoimmune, neurological, neuropsychiatric conditions, however knowledge its particular pathogenic role ADHD sparse. As such, this narrative review examines synthesizes available related to inflammation, neural processes ADHD. Minimal differences microbiota diversity measures between cases controls were found, relative abundance observed at all classification levels (phylum strain). Compositional taxa important key gut-brain axis pathways, Bacteroides species Faecalibacterium, may contribute brain functioning differences, symptoms, We have identified one possible model etiopathogenesis involving systemic an impaired blood-brain barrier, disturbances as downstream consequences dysbiosis. Nevertheless, studies conducted date varied degrees methodological rigour involve diverse participant characteristics analytical techniques, highlighting a need additional research.

Язык: Английский

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Integrative analysis of intestinal flora and untargeted metabolomics in attention-deficit/hyperactivity disorder

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Янв. 29, 2025

Attention Deficit Hyperactivity Disorder (ADHD) is a clinically common neurodevelopmental disorder of the brain. In addition to genetic factors, an imbalance in gut flora may also play role development ADHD. Currently, it critical investigate function and related metabolites, which form fundamental basis bidirectional cross-linking between brain gut, focusing on changed This study aimed possible relationship changes metabolites ADHD by analyzing metagenome untargeted metabolomics fecal samples from patients. Specifically, we attempted identify key metabolic pathways they are involved in, as well analyze detail structure composition order further symptoms, some behavioral studies were conducted following transplantation patients into rats. The results analysis revealed several distinct strains, including Bacteroides cellulosilyticus , could be important for diagnosing Additionally, group showed modifications nicotinamide nicotinic acid metabolite this pathway. demonstrated that rats with transplants displayed increased locomotor activity interest, indicating onset behaviors such facilitated associated research verified alterations metabolism observed provided list significantly altered Simultaneously, our findings microbiome potentially trigger animals, providing experimental comprehending influence These might provide new perspectives novel treatment strategies.

Язык: Английский

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Gut microbiome changes with micronutrient supplementation in children with attention–deficit/hyperactivity disorder: the MADDY study

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 18, 2025

Micronutrients have demonstrated promise in managing inattention and emotional dysregulation children with attention-deficit/hyperactivity disorder (ADHD). One plausible pathway by which micronutrients improve symptoms is the gut microbiome. This study examines changes fecal microbial composition diversity after micronutrient supplementation ADHD (N = 44) highlights potential mechanisms responsible for behavioral improvement, as determined blinded clinician-rated global improvement response to micronutrients. Participants represent a sub-group of Youth (MADDY) study, double blind randomized controlled trial participants received or placebo 8 weeks, followed an 8-week open extension. Stool samples collected at baseline, week 8, 16 were analyzed using 16S rRNA amplicon sequencing targeting V4 hypervariable region. Pairwise compositional analyses investigated between versus responders non-responders. A significant change evenness, measured alpha diversity, beta-diversity, Bray-Curtis, was observed following supplementation. The phylum Actinobacteriota decreased group compared placebo. Two butyrate-producing bacterial families: Rikenellaceae Oscillospiraceae, exhibited increase These findings suggest that modulated microbiota identified specific associated responders.

Язык: Английский

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Predictive analysis of the impact of probiotic administration during pregnancy on the functional pathways of the gut microbiome in healthy infants based on 16S rRNA gene sequencing

Gene, Год журнала: 2025, Номер 952, С. 149414 - 149414

Опубликована: Март 12, 2025

Язык: Английский

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The Gut Microbiome-Neuroglia Axis: Implications for Brain Health, Inflammation, and Disease

Neuroglia, Год журнала: 2024, Номер 5(3), С. 254 - 273

Опубликована: Авг. 1, 2024

The human central nervous system is convolutedly connected to the gut microbiome, a diverse community of microorganisms residing in gastrointestinal tract. Recent research has highlighted bidirectional communication between microbiome and neuroglial cells, which include astrocytes, microglia, oligodendrocytes, ependymal cells. These cells are essential for maintaining CNS homeostasis, supporting neuronal function, responding pathological conditions. This review examines interactions neuroglia, emphasizing their critical roles brain health development neurological disorders. Dysbiosis, or imbalance been associated with various psychiatric conditions, such as autism spectrum disorder, anxiety, depression, neurodegenerative diseases like Alzheimer’s Parkinson’s. influences function through microbial metabolites, immune modulation, neuroinflammatory responses. Understanding these paves way new therapeutic targets strategies preventing treating scoping aims highlight mechanisms microbiome-neuroglia axis its potential target.

Язык: Английский

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Enhancing pediatric attention-deficit hyperactivity disorder treatment: exploring the gut microbiota effects of French maritime pine bark extract and methylphenidate intervention

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Авг. 27, 2024

Introduction The pathogenesis of Attention-Deficit Hyperactivity Disorder (ADHD) is thought to be multifactorial, with a potential role for the bidirectional communication between gut microbiome and brain development function. Since “golden-standard” medication therapy methylphenidate (MPH) linked multiple adverse effects, there need alternative treatment options such as dietary polyphenols. These secondary plant metabolites exert antioxidant anti-inflammatory but much less known about their impact on microbiota. polyphenols are believed modulate microbial composition, interventions might advantageous in ADHD therapy. Therefore, intervention studies investigating composition highly relevant. Methods Besides primary research questions addressed previously, this study explored prebiotic effect polyphenol-rich French Maritime Pine Bark Extract (PBE) compared MPH placebo pediatric patients by studying microbiota via amplicon sequencing full length 16S rRNA gene ribosomal subunit (V1-V9). Results One interesting finding was high relative abundance Bifidobacteria among all our cohort. Moreover, has identified that (placebo, PBE) explains 3.94% variation distribution taxa (adjusted p -value 0.011). Discussion Our small sample size (placebo: n = 10; PBE: 13 MPH: 14) did not allow observe clear effects treated PBE. Notwithstanding limitation, subtle changes were noticeable some limited compositional could observed. Clinical Trial Registration doi: 10.1186/S13063-017-1879-6

Язык: Английский

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Attention Deficit Hyperactivity Disorder (ADHD) and the gut microbiome: An ecological perspective

PLoS ONE, Год журнала: 2023, Номер 18(8), С. e0273890 - e0273890

Опубликована: Авг. 18, 2023

Attention Deficit Hyperactivity Disorder (ADHD) is an increasingly prevalent neuropsychiatric disorder characterized by hyperactivity, inattention, and impulsivity. Symptoms emerge from underlying deficiencies in neurocircuitry, recent research has suggested a role played the gut microbiome. The microbiome ecosystem of interdependent taxa involved exponentially complex web interactions, plus host gene reaction pathways, some which involve neurotransmitters with roles ADHD neurocircuitry. Studies have analyzed using macroscale metrics such as diversity differential abundance, proposed several elevated or reduced compared to Control. Few studies delved into dynamics ultimately responsible for emergence metrics, leaving largely incomplete, sometimes contradictory, inconclusive picture. We aim help complete this picture venturing beyond abundances relationships (i.e. cooperation competition), publicly available dataset (targeted 16S, v3-4 region, qPCR) observational, case-control study 30 Control (15 female, 15 male) 28 13 undergraduate students. first perform same analyses literature (diversity, composition) observe degree correspondence, any new trends. then estimate two-way ecological producing Microbial Co-occurrence Networks (MCNs), SparCC correlations ( p ≤ 0.01). community detection find clusters estimated mutually cooperate along their centroids, centrality calculations most vital overall ecology. finally summarize our results, providing conjectures on how they can guide future experiments, methods improving general implications field.

Язык: Английский

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Cytokine Levels and Neuropsychological Function among Patients with Attention-Deficit/Hyperactivity Disorder and Atopic Diseases

Journal of Personalized Medicine, Год журнала: 2022, Номер 12(7), С. 1155 - 1155

Опубликована: Июль 17, 2022

Since atopic disease and inflammatory cytokines are both involved in attention deficit hyperactivity disorder (ADHD), this study, we examined the relationship among cytokine levels, neuropsychological function, behavioral manifestations patients with ADHD diseases. Participants were categorized into individuals (n = 41), those without allergy 74), but 23), or 49). We used Swanson, Nolan, Pelham IV Scale (SNAP-IV), Conners’ Continuous Performance Test (Conners CPT), Auditory of Attention (CATA) to assess patients’ symptoms, visual attention, auditory respectively. Participants’ IFN-γ, IL-1B, IL-6, IL-10, IL-13, IL-17, MCP-1, TNF-α plasma levels assessed using multiplex assays. found that prevalence rates diseases (asthma, allergic rhinitis, dermatitis) similar between ADHD. symptoms CPT omission scores, CATA detectability scores demonstrated significant differences ADHD, regardless However, (TNF-α, IL-17) negatively correlated inattention symptoms. This study demonstrates a potential function

Язык: Английский

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