Early-life stress alters postnatal chromatin development in the nucleus accumbens

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 13, 2024

ABSTRACT Early-life stress sensitizes individuals to subsequent stressors increase lifetime risk for psychiatric disorders. Within the nucleus accumbens (NAc) — a key limbic brain region early-life both cellular and transcriptional response later stress. However, molecular mechanisms linking initial activation of neurons by with continued sensitivity across lifespan are poorly understood. Using combination activity-dependent tagging ATAC-sequencing postnatal development, we find that initially opens chromatin in stress-activated cells opening predicts gene expression adult stress, suggesting epigenetic priming as mechanism sensitization. Moreover, accelerates development within these activated cells, H3K4me1 deposition broadly NAc post-translational histone modification associated open priming. By adulthood, observe remodeling throughout NAc, indicating effects long-lasting propagate into broader cell population. Lastly, through viral-mediated epigenome editing behavioral quantification, during early is sufficient mimic prime hypersensitivity Together, our results show memory encoded at an level changes architecture. This constitutes novel biological which programs lifelong sensitivity.

Язык: Английский

Depression and cardiovascular reactions to acute psychological stress: Is anhedonia the driver?

International Journal of Psychophysiology, Год журнала: 2024, Номер 207, С. 112492 - 112492

Опубликована: Дек. 21, 2024

Язык: Английский