Impact of cannabinoids on cancer outcomes in patients receiving immune checkpoint inhibitor immunotherapy
MariaLuisa Vigano,
Lixing Wang,
Alia As’sadiq
и другие.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 5, 2025
Cannabinoids
relieve
pain,
nausea,
anorexia
and
anxiety,
improve
quality
of
life
in
several
cancer
patients.
The
immunotherapy
with
checkpoint
inhibitors
(ICIs),
although
very
successful
a
subset
patients,
is
accompanied
by
moderate
to
severe
immune-related
adverse
events
(ir-AE)
that
often
necessitate
its
discontinuation.
Because
their
role
symptomatic
relief,
cannabinoids
have
been
used
combination
immune
inhibitor
(ICI)
immunotherapy.
A
few
studies
strongly
suggest
the
use
medicinal
cannabis
patients
attenuates
many
ir-AE
associated
ICI
increase
tolerability.
However,
no
significant
beneficial
effects
on
overall
survival,
progression
free
survival
or
relapses
were
observed;
rather,
some
noted
concurrent
administration
clinical
benefits
latter.
cannabinoids'
well
documented
immunosuppressive
mediated
through
cannabinoid
recptor-2
(CB2),
we
propose
considering
this
receptor
as
an
inhibitory
per
se.
simultaneous
neutralization
CB2,
treatment,
may
lead
better
outcomes
receiving
In
regard,
such
cannabidiol
(CBD)
cannabigerol
(CBG),
little
agonism
for
be
therapeutic
choices.
Additional
strategies
e.g.,
monoacylglycerol
lipase
(MAGL)
degrade
endocannabinoids
lipogenesis
formation
lipid
bilayers
cells
also
explored.
Future
should
take
into
consideration
gut
microbiota,
CYP450
polymorphism
haplotypes,
cannabinoid-drug
interactions
genetic
somatic
variations
occurring
receptors
signaling
pathways
personalized
cannabis-based
therapies
ICIs.
This
rational
knowledge-based
regimens
tailored
individual
Язык: Английский
Modulation of neuroinflammation and oxidative stress by targeting GPR55 – new approaches in the treatment of psychiatric disorders
Molecular Psychiatry,
Год журнала:
2024,
Номер
29(12), С. 3779 - 3788
Опубликована: Май 25, 2024
Pharmacological
treatment
of
psychiatric
disorders
remains
challenging
in
clinical,
pharmacological,
and
scientific
practice.
Even
if
many
different
substances
are
established
for
treating
conditions,
subgroups
patients
show
only
small
or
no
response
to
the
treatment.
The
neuroinflammatory
hypothesis
genesis
might
explain
underlying
mechanisms
these
non-responders.
For
that
reason,
recent
research
focus
on
processes
oxidative
stress
as
possible
causes
disorders.
G-protein
coupled
receptors
(GPCRs)
form
biggest
superfamily
membrane-bound
already
well
known
pharmacological
targets
various
diseases.
receptor
55
(GPR55),
a
considered
part
endocannabinoid
system,
reveals
promising
modulation
processes.
Different
agonists
antagonists
reduce
pro-inflammatory
cytokine
release,
enhance
synthesis
anti-inflammatory
mediators,
protect
cells
from
damage.
this
GPR55
ligands
be
compounds
suffering
related
neuroinflammation
stress.
New
approaches
drug
design
lead
new
targeting
pathomechanisms
those
just
one
molecule.
Язык: Английский
The role of cannabinoid-mediated signaling pathways and mechanisms in brain disorders
Cellular Signalling,
Год журнала:
2025,
Номер
unknown, С. 111653 - 111653
Опубликована: Фев. 1, 2025
Язык: Английский
The endocannabinoid and paracannabinoid systems in natural reward processes: possible pharmacological targets?
Physiology & Behavior,
Год журнала:
2025,
Номер
296, С. 114929 - 114929
Опубликована: Апрель 22, 2025
Язык: Английский
Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence
Cells,
Год журнала:
2024,
Номер
13(22), С. 1875 - 1875
Опубликована: Ноя. 13, 2024
The
endocannabinoid
signalling
system
(ECS)
plays
a
critical
role
from
the
very
beginning
of
embryogenesis.
Accordingly,
ECS
is
engaged
early
on
in
nervous
development,
starting
neurulation,
supported
by
identification
components—both
receptors
and
enzymes
controlling
metabolism—at
these
stages.
In
particular,
regarding
brain,
involved
tightly
regulated
sequence
events
that
comprise
brain
neurogenesis
to
neuronal
migration,
morphological
guidance
for
connectivity,
synaptic
circuitry
refinement.
importance
this
broad
across
various
development
processes
further
underscored
growing
understanding
consequences
cannabis
exposure
at
different
developmental
Despite
considerable
knowledge
we
have
significant
gaps
our
remain,
particularly
long-term
impact
underlying
mechanisms
This
review
provides
an
overview
current
state
throughout
embryogenesis
adulthood,
discusses
exposure,
especially
during
adolescence—a
period
maturation
refinement
coinciding
with
increased
risk
use.
Язык: Английский
Orphan GPCRs in Neurodegenerative Disorders: Integrating Structural Biology and Drug Discovery Approaches
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(10), С. 11646 - 11664
Опубликована: Окт. 19, 2024
Neurodegenerative
disorders,
particularly
Alzheimer's
and
Parkinson's
diseases,
continue
to
challenge
modern
medicine
despite
therapeutic
advances.
Orphan
G-protein-coupled
receptors
(GPCRs)
have
emerged
as
promising
targets
in
the
central
nervous
system,
offering
new
avenues
for
drug
development.
This
review
focuses
on
structural
biology
of
orphan
GPCRs
implicated
these
providing
a
comprehensive
analysis
their
molecular
architecture
functional
mechanisms.
We
examine
recent
breakthroughs
determination
techniques,
such
cryo-electron
microscopy
X-ray
crystallography,
which
elucidated
intricate
conformations
receptors.
The
highlights
how
insights
inform
our
understanding
GPCR
activation,
ligand
binding
signaling
pathways.
By
integrating
data
with
pharmacology,
we
explore
potential
structure-guided
approaches
developing
targeted
therapeutics
toward
GPCRs.
structural-biology-centered
perspective
aims
deepen
comprehension
guide
future
discovery
efforts
neurodegenerative
disorders.
Язык: Английский