Toxics,
Год журнала:
2024,
Номер
12(12), С. 918 - 918
Опубликована: Дек. 19, 2024
Brominated
flame
retardants
(BFRs)
are
a
type
of
widespread
pollutant
that
can
be
transmitted
through
particulate
matter,
such
as
dust
in
the
air,
and
have
been
associated
with
various
adverse
health
effects,
diabetes,
metabolic
syndrome,
cardiovascular
disease.
However,
there
is
limited
research
on
link
between
exposure
to
mixtures
BFRs
depression
general
population.
To
analyze
association
population,
nationally
representative
data
from
National
Health
Nutrition
Examination
Survey
(NHANES;
2005-2016)
were
used.
In
final
analysis,
total
8138
adults
aged
20
years
older
included.
investigate
potential
relationship
outcomes,
we
used
binary
logistic
regression,
restricted
cubic
spline
(RCS),
quantile-based
g
computation
(QGC),
weighted
quantile
sum
(WQS)
regression.
The
findings
showed
serum
BFR
concentrations
depressive
symptoms
over
broad
spectrum.
Binary
regression
RCS
analysis
certain
BFRs,
particularly
PBB153,
significantly
positively
incidence
depression,
even
after
adjustment
for
confounders
(p
<
0.05).
Mixed
was
also
found
stronger
men.
two
most
influential
PBB153
PBDE85,
identified
both
mixed
models
risk
factors
concern.
Our
study
new
insights
into
but
sizable
population-based
cohort
studies
toxicology
mechanism
will
needed
establish
causality.
Saudi Pharmaceutical Journal,
Год журнала:
2023,
Номер
32(2), С. 101928 - 101928
Опубликована: Дек. 19, 2023
The
lost
dopaminergic
neurons
in
the
brain
prevent
mobility
Parkinson's
disease
(PD).
It
is
impossible
to
stop
disease's
progress
by
means
of
symptoms
management.
Research
focuses
on
oxidative
stress,
mitochondrial
dysfunction,
and
neuronal
degeneration.
Exploration
potential
neuroprotective
drugs
against
prosurvival
B-cell
lymphoma
2
(Bcl-2)
protein
ongoing.
An
investigable
cause
behind
PD,
as
well
preventive
measures,
could
be
discovered
considering
association
between
such
behavioural
manifestations
(cataleptic
behaviours)
PD.
compound
Afzelin,
known
guard
nervous
system,
was
chosen
for
this
study.
study
done
rats
divided
into
six
different
groups.
First,
there
a
control
group.
other
group
treated
with
Reserpine
(RES)
(1
mg/kg).
third
received
RES
mg/kg)
levodopa
(30
remaining
three
groups
were
given
conjunction
Afzelin
at
following
doses:
5
mg/kg,
10
20
mg/kg.
Cataleptic
behavior
assessed
using
rotarod,
open
field,
modified
forced-swim
tests.
thiobarbituric
acid
reactive
substances
(TBARS),
nitric
oxide
(NO),
biogenic
amines,
Bcl-2
level
rat
tissue
homogenates
considered.
According
study's
findings,
through
co-administration
improved
significantly
their
cataleptic
behaviours
locomotor
activity.
In
addition,
administering
itself
caused
expression,
which
have
some
neuroprotection
properties.
This
provides
meaningful
information
effectiveness
handling
catalepsy
degenerative
neurologic
disorders.
As
result,
studies
need
conducted
establish
reasons
reactions
determine
long-term
effects
these
conditions.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 16, 2024
Abstract
This
study
explored
the
neurogenic
and
microglial
modulatory
properties
of
botulinum
toxin
in
hippocampus
aging
experimental
mice.
Therapeutic
(BoNT)
treatment
is
widely
practiced
to
reduce
excessive
discharge
acetylcholine
(ACh)
management
neurological
deficits.
While
production
new
neurons
adult
brain
contributes
cognitive
functions,
age-related
diseases
with
release
ACh
progressive
neuroinflammation
have
been
characterized
by
impaired
hippocampal
neurogenesis
memory
loss.
Therefore,
we
investigated
effect
BoNT
on
regulation
neurogenesis,
focusing
doublecortin
(DCX)-positive
immature
We
also
assessed
ionized
calcium-binding
adapter
molecule
1
(Iba1)-positive
microglia
expression
cyclooxygenase
(COX)-2,
a
key
inflammatory
response
element,
using
reverse
transcription
polymerase
chain
reaction
(RT-PCR).
Results
revealed
prominent
increase
DCX-positive
cells
BoNT-treated
animals
compared
control
group.
Additionally,
reduced
number
accompanied
decreased
mRNA
COX-2
was
evident
animals.
These
dual
effects
suggest
that
could
be
promising
therapeutic
agent
for
mitigating
neuroregenerative
decline
responsible
impairments.
Molecular Neurobiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 3, 2024
Abstract
NLRP3
inflammasomes-mediated
proinflammatory
response
and
mitochondrial
dysfunction
play
a
critical
role
in
the
etiology
pathogenesis
of
Parkinson's
disease.
Negative
regulation
inflammasome
activation
through
mitophagy
may
be
an
important
strategy
to
control
inflammasome-mediated
responses.
Palmatine
(PAL),
isoquinoline
alkaloid
found
various
plants,
has
potent
pharmacological
effects
such
as
anti-inflammatory
anti-oxidation.
However,
specific
PAL
pathology
disease
remains
unclear.
In
this
study,
we
that
treatment
with
improved
motor
deficits
reduced
loss
dopaminergic
neurons
MPTP
mice.
Further
results
showed
promoted
inhibited
mediated
by
inflammasomes.
addition,
chloroquine
(CQ,
inhibitor)
attenuated
ameliorative
on
neuron
damage,
well
inhibitory
effect
inflammasome.
Collectively,
these
provide
strong
evidence
ameliorates
death
Parkinson’s
disease,
mechanism
related
its
inhibition
via
promoting
mitophagy.
Toxics,
Год журнала:
2024,
Номер
12(12), С. 918 - 918
Опубликована: Дек. 19, 2024
Brominated
flame
retardants
(BFRs)
are
a
type
of
widespread
pollutant
that
can
be
transmitted
through
particulate
matter,
such
as
dust
in
the
air,
and
have
been
associated
with
various
adverse
health
effects,
diabetes,
metabolic
syndrome,
cardiovascular
disease.
However,
there
is
limited
research
on
link
between
exposure
to
mixtures
BFRs
depression
general
population.
To
analyze
association
population,
nationally
representative
data
from
National
Health
Nutrition
Examination
Survey
(NHANES;
2005-2016)
were
used.
In
final
analysis,
total
8138
adults
aged
20
years
older
included.
investigate
potential
relationship
outcomes,
we
used
binary
logistic
regression,
restricted
cubic
spline
(RCS),
quantile-based
g
computation
(QGC),
weighted
quantile
sum
(WQS)
regression.
The
findings
showed
serum
BFR
concentrations
depressive
symptoms
over
broad
spectrum.
Binary
regression
RCS
analysis
certain
BFRs,
particularly
PBB153,
significantly
positively
incidence
depression,
even
after
adjustment
for
confounders
(p
<
0.05).
Mixed
was
also
found
stronger
men.
two
most
influential
PBB153
PBDE85,
identified
both
mixed
models
risk
factors
concern.
Our
study
new
insights
into
but
sizable
population-based
cohort
studies
toxicology
mechanism
will
needed
establish
causality.
