Colchicine Inhibits Smooth Muscle Cell Phenotypic Switch and Aortic Dissection in Mice

Arteriosclerosis Thrombosis and Vascular Biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

BACKGROUND: Aortic dissection (AD) is a severe cardiovascular disorder characterized by intimal tearing and subsequent delamination of the aortic wall. The pathogenesis AD primarily involves phenotypic switch vascular smooth muscle cells (VSMCs), degradation extracellular matrix, chronic inflammation. Colchicine, an alkaloid derived from Colchicum autumnale L , Food Drug Administration–approved anti-inflammatory drug with established therapeutic applications in diseases. However, its potential role modulating development or progression remains largely unexplored. METHODS: To investigate effects colchicine on AD, β-aminopropionitrile–induced mouse model was used. Colchicine administered via oral gavage over 3-week period to evaluate impact incidence mortality male C57BL/6J mice. Transcriptome sequencing performed identify genes signaling pathways regulated colchicine. Additionally, vitro experiments using primary rat VSMCs were conducted elucidate mechanisms underlying colchicine-mediated regulation VSMC switch. RESULTS: demonstrated protective effect against attenuating inflammation suppressing Mechanistically, reverses at least partially expression myocardin, key regulator contractile phenotype. Transcriptomic analysis further revealed specific influenced colchicine, providing insights into molecular action. CONCLUSIONS: This study identifies as for highlighting ability mitigate hallmark pathological processes such These findings offer foundation base repurposed clinical application which warrants investigation.

Язык: Английский

Advances in the analysis and application of metabolites from tropical plants

Current Opinion in Plant Biology, Год журнала: 2025, Номер 85, С. 102728 - 102728

Опубликована: Апрель 24, 2025

Язык: Английский