Biodegradable ultrahigh-purity magnesium and its alloy ZX00 promote osteogenesis in the medullary cavity and glycogenolysis in the liver
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Magnesium
(Mg)-based
implants
have
become
an
attractive
alternative
to
conventional
permanent
in
the
orthopedic
field.
While
biocompatibility,
degradation
kinetics,
and
osseointegration
of
Mg-based
been
mostly
investigated,
impact
products
on
bone
remodeling
potential
systemic
effects
remains
unclear.
The
aim
this
study
was
evaluate
early
mid-term
local
tissue
responses
degrading
ultrahigh-purity
ZX00
(Mg-Zn-Ca
alloy)
Mg
(XHP-Mg)
pins
a
juvenile
healthy
rat
model.
differences
between
implant
types
(degradable
vs.
permanent),
implantation,
age-related
changes
were
investigated
using
titanium
(Ti),
sham-operated,
control
groups
(non-intervention),
respectively.
Degradation
XHP-Mg
promote
osteogenesis
medullary
cavity
by
upregulating
expression
levels
Bmp2
Opg
within
14
days
post-surgery.
higher
rate
resulted
accumulation
starting
from
day
3
upregulation
different
genes,
particularly
Ccl2
Cepbp.
Besides
good
new
formation,
we
found
more
parallel
hydroxyapatite/collagen
orientation
along
perimeter
region
compared
Ti
pins.
In
liver,
reduced
glycogen
indicated
that
glycogenolysis,
while
only
group
showed
serum
glucagon
level
14.
Results
suggest
stimulate
mainly
via
glycogenolysis
genes
metabolites.
STATEMENT
OF
SIGNIFICANCE:
Bioresorbable
magnesium
are
promising
candidates
for
interventions.
Until
now,
few
vivo
studies
explored
how
modulate
responses.
Herein,
results
demonstrate
i)
has
crucial
effect
regulating
cavity,
ii)
HAp/collagen
matrix
pattern
group,
iii)
both
liver.
Our
findings
highlight
dual
role
metabolic
modulation.
Nevertheless,
is
first
report
interaction
liver
metabolism.
Язык: Английский
Causal inference study of plasma proteins and blood metabolites mediating the effect of obesity-related indicators on osteoporosis
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 18, 2025
Osteoporosis
and
obesity
are
both
major
global
public
health
problems.
Observational
studies
have
found
that
osteoporosis
might
be
related
to
obesity.
Mendelian
randomization
(MR)
analysis
could
overcome
the
limitations
of
observational
in
assessing
causal
relationships.
This
study
aims
evaluate
potential
relationship
between
obesity-related
indicators
by
using
a
two-sample
MR
identify
mediators.
A
total
53
indicators,
3,282
plasma
protein
lists,
452
blood
metabolite
lists
were
downloaded
from
data
set
as
instrumental
variables,
GWAS
MRC
IEU
Open
database
was
used
outcome
indicators.
Using
univariate
MR,
multivariate
intermediate
mediating
factors
identified.
The
IVW
model
results
show
31
may
significant
with
(P
<
0.05),
except
for
waist
circumference
(id:
Ieu-a-71,
OR
=
1.00566);
remaining
30
reduce
risk
(OR:
0.983-0.996).
25
10
them,
such
ANKED46,
KLRF1,
LPO,
CA9
protective
effect
on
0.996-0.999),
while
other
15
ATP1B1,
zinc
finger
175,
increase
1.001-1.004).
For
alanine
Met
a-469,
OR:
1.071),
six
including
uridine
1-linoleoylglycerophosphoethanolaminecan
0.05,
0.961-0.992).
direction
is
all
correct;
heterogeneity
not
affected
horizontal
pleiotropy.
mediated
analysis,
it
against
histone-lysine
N-methyltransferase
proteins
metabolites.
Obesity
confer
osteoporosis,
potentially
EHMT2
Further
empirical
research
required
fully
elucidate
mechanisms
behind
influence
osteoporosis.
Interventions
controlling
adverse
effects
associated
require
further
research.
Язык: Английский
Modulatory role of exogenous arachidonic acid in periodontitis with type 2 diabetes mellitus mice
BMC Oral Health,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 19, 2025
Type
2
diabetes
mellitus
(T2DM)
exhibits
a
bidirectional
relationship
with
periodontitis,
wherein
each
condition
influences
the
progression
of
other.
Arachidonic
acid
(AA)
exerts
an
anti-diabetic
effect,
while
showing
protective
effect
by
regulating
inflammatory
response
independently
its
metabolites.
However,
impact
on
periodontitis
T2DM
remains
poorly
understood.
The
mouse
model
was
established
combining
high-sugar
and
high-fat
diet
streptozotocin
injection,
followed
silk
ligation
to
induce
periodontitis.
Alterations
in
diabetes-associated
symptoms
were
evaluated.
Micro-computed
tomography
used
measure
bone-related
parameters,
including
distance
from
cementoenamel
junction
alveolar
bone
crest,
volume/total
volume
mineral
density.
Targeted
metabolomics
analysis
conducted
evaluate
exogenous
AA
serum
metabolite
levels
mice
type
diabetic
16S
rRNA
gene
sequencing
utilized
analyze
microbial
diversity.
activity
osteoclasts,
factors
expression
related
osteoclasts
investigated
using
TRAP
staining
real-time
quantitative
PCR.
successfully
established.
Following
two
weeks
treatment,
reduction
fasting
blood
glucose
observed
mice.
Exogenous
alleviated
loss
it
had
no
substantial
contents
AA-targeted
reduced
Staphylococcus
subgingival
flora
mice,
but
significant
community
structure
or
Furthermore,
decreased
number
increased
IL-10
mRNA
gingival
tissue.
may
alleviate
reducing
increasing
periodontal
tissues,
rather
than
change
metabolites
composition
diversity
microorganisms
plaque.
These
findings
provide
potential
therapeutic
approach
for
prevention
treatment
T2DM.
Язык: Английский