The European Research Journal,
Год журнала:
2024,
Номер
10(6), С. 634 - 643
Опубликована: Июль 15, 2024
Endometrial
polyps
and
uterine
leiomyomas
are
common
gynecological
conditions
that
significantly
affect
women's
health.
Recent
studies
have
begun
to
explore
potential
biomarkers
could
assist
in
the
early
diagnosis
understanding
of
pathophysiology
these
conditions.
One
such
biomarker
is
Serum
Sestrin
2
(SESN2),
a
protein
involved
cellular
stress
response.
This
review
aims
synthesize
research
findings
on
relationship
between
serum
SESN2
levels
presence
endometrial
leiomyomas.
It
examines
as
diagnostic
tool
its
role
underlying
mechanisms
Studies
suggest
elevated
patients
with
compared
controls,
indicating
involvement
their
pathophysiology.
Furthermore,
discusses
implications
for
clinical
practice,
particularly
terms
detection
targeted
therapies.
Future
directions
need
large-scale
validate
marker
also
addressed.
highlights
importance
like
enhancing
our
management
disorders.
Biomolecules,
Год журнала:
2024,
Номер
14(3), С. 260 - 260
Опубликована: Фев. 22, 2024
Anti-ageing
biology
and
medicine
programmes
are
a
focus
of
genetics,
molecular
biology,
immunology,
endocrinology,
nutrition,
therapy.
This
paper
discusses
metabolic
therapies
aimed
at
prolonging
longevity
and/or
health.
Individual
components
these
effects
postulated
to
be
related
the
energy
supply
by
tricarboxylic
acid
(TCA)
cycle
intermediates
free
radical
production
processes.
article
presents
several
theories
ageing
clinical
descriptions
top
markers
ageing,
which
define
in
different
categories;
additionally,
their
interactions
with
age-related
changes
diseases
α-ketoglutarate
(AKG)
succinate
SC
formation
metabolism
pathological
states
explained.
review
describes
convincingly
differences
mitochondrial
characteristics
animals,
levels
(high
low)
physiological
reactivity
functional
systems
state
regulatory
providing
oxygen-dependent
Much
attention
is
given
crucial
role
AKG
cells
amino
synthesis,
epigenetic
regulation,
cell
stemness,
differentiation,
as
well
associated
development
conditions
and,
particular,
cancer
cells.
Another
goal
was
address
issue
terms
individual
reactivity.
also
demonstrated
Krebs
key
component
cellular
closely
various
pathologies,
such
cancer,
type
2
diabetes,
cardiovascular
or
neurodegenerative
where
mTOR
pathway
plays
role.
provides
postulates
postischaemic
phenomena
an
organism
demonstrates
dependence
accelerated
pathology
on
studies
species
(roundworm
Caenorhabditis
elegans,
Drosophila,
mice,
humans
used
models).
The
findings
suggest
that
this
approach
may
useful
show
metabolites
involved
abnormalities
thus
induce
reprogramming
contributes
senile
phenotype
degenerative
diseases.
compounds
particularly
important
when
considering
mechanisms
connected
initial
able
initiate
programmed
depending
intensity
oxygen
consumption,
peculiarities,
behavioural
reactions.
Free Radical Biology and Medicine,
Год журнала:
2024,
Номер
214, С. 115 - 128
Опубликована: Фев. 6, 2024
Sestrins
are
metabolic
regulators
that
respond
to
stress
by
reducing
the
levels
of
reactive
oxygen
species
(ROS)
and
inhibiting
activity
target
rapamycin
complex
1
(mTORC1).
Previous
research
has
demonstrated
Sestrin2
mitigates
ischemia-reperfusion
(IR)
injury
in
heart,
liver,
kidneys.
However,
its
specific
role
IIR
remains
unclear.
To
elucidate
intestinal
injury,
we
conducted
an
experimental
study
using
a
C57BL/6J
mouse
model
IIR.
We
noticed
increase
expression
indicators
associated
with
ferroptosis.
Our
revealed
manipulating
Caco-2
cells
through
overexpression
or
knockdown
resulted
corresponding
decrease
increase,
respectively,
ferroptosis
levels.
Furthermore,
our
investigation
alleviated
caused
activation
Keap1/Nrf2
signaling
pathway.
This
finding
highlights
potential
as
therapeutic
for
alleviating
injury.
These
findings
indicated
modulation
could
be
promising
strategy
managing
prolonged
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Март 3, 2025
As
a
highly
conserved
cellular
process,
autophagy
has
been
the
focus
of
extensive
research
due
to
its
critical
role
in
maintaining
homeostasis
and
implications
cardiovascular
pathogenesis.
The
decline
muscular
function,
along
with
neuronal
system,
increased
sensitivity
stress
have
recognized
multiple
animal
models.
Autophagic
defects
architecture
dysfunction
linked
both
physiological
pathological
conditions
heart
mammals
Drosophila
.
In
this
review,
we
systematically
analyze
autophagy-associated
pathways
hearts
fruit
flies
aim
provide
comprehensive
understanding
for
developing
potential
treatments
patients
effective
strategies
agricultural
applications.
This
analysis
elucidates
molecular
mechanisms
function
under
,
offering
significant
insights
into
development
diseases.
loss
key
proteins,
including
transmembrane
protein
Atg9
partners
Atg2
or
Atg18,
DmSestrin,
leads
cardiac
hypertrophy
structural
abnormalities
resembling
age-dependent
deterioration
function.
Members
autophagy-related
(Atg)
gene
family,
nuclear
skeletal
lamins,
mechanistic
mammalian
target
rapamycin
(mTOR)
signaling
are
critically
influential
activation
shown
suppress
laminopathy.
mTORC1/C2
complexes,
axis
Atg2-AMPK/Sirt1/PGC-1α
pathway,
essential
flies,
governing
development,
growth,
maturation,
maintenance
homeostasis.
beneficial
effects
several
interventions
that
enhance
exercise
cold
stress,
can
influence
autophagy-dependent
TOR
activity
serine/threonine
kinase
Exercise
increase
when
it
is
deficient
inhibit
excessive,
highlighting
dual
health.
review
evaluates
functional
significance
heart,
particularly
context
relation
mTORC-associated
pathways.
It
contrasts
underlying
mammals.
evolutionary
conservation
underscores
value
as
model
broader
across
species.
study
not
only
deepens
our
autophagy’s
but
also
provides
theoretical
foundation
application
pest
control.
