The European Research Journal,
Год журнала:
2024,
Номер
10(6), С. 634 - 643
Опубликована: Июль 15, 2024
Endometrial
polyps
and
uterine
leiomyomas
are
common
gynecological
conditions
that
significantly
affect
women's
health.
Recent
studies
have
begun
to
explore
potential
biomarkers
could
assist
in
the
early
diagnosis
understanding
of
pathophysiology
these
conditions.
One
such
biomarker
is
Serum
Sestrin
2
(SESN2),
a
protein
involved
cellular
stress
response.
This
review
aims
synthesize
research
findings
on
relationship
between
serum
SESN2
levels
presence
endometrial
leiomyomas.
It
examines
as
diagnostic
tool
its
role
underlying
mechanisms
Studies
suggest
elevated
patients
with
compared
controls,
indicating
involvement
their
pathophysiology.
Furthermore,
discusses
implications
for
clinical
practice,
particularly
terms
detection
targeted
therapies.
Future
directions
need
large-scale
validate
marker
also
addressed.
highlights
importance
like
enhancing
our
management
disorders.
Heliyon,
Год журнала:
2024,
Номер
10(5), С. e27571 - e27571
Опубликована: Март 1, 2024
The
role
of
fat
mass
and
obesity-associated
protein
(FTO),
an
N6-methyladenosine
(m6A)
demethylase,
in
non-small
cell
lung
cancer
(NSCLC)
has
recently
received
widespread
attention.
However
the
underlying
mechanisms
FTO-mediated
autophagy
regulation
NSCLC
progression
remain
elusive.
In
this
study,
we
found
that
FTO
was
significantly
upregulated
NSCLC,
downregulation
suppressed
growth,
invasion
migration
cells
by
inducing
autophagy.
knockdown
resulted
elevated
m6A
levels
cells.
Methylated
RNA
immunoprecipitation
sequencing
showed
sestrin
2
(SESN2)
involved
during
Interestingly,
modifications
exon
9
SESN2
regulated
its
stability.
deficiency
promoted
binding
insulin-like
growth
factor
mRNA-binding
1
to
mRNA,
enhancing
stability
elevating
expression.
inhibited
autophagic
flux
downregulating
SESN2,
thereby
promoting
Besides,
mechanism
which
blocked
SESN2-mediated
activation
associated
with
AMPK-mTOR
signaling
pathway.
Taken
together,
these
findings
uncover
essential
FTO–autophagy–SESN2
axis
progression.
Molecular Metabolism,
Год журнала:
2023,
Номер
80, С. 101865 - 101865
Опубликована: Дек. 30, 2023
Necroptosis,
a
novel
type
of
programmed
cell
death,
is
intricately
associated
with
inflammatory
response.
Currently,
most
studies
focus
on
the
activation
necroptosis,
while
mechanisms
underlying
negative
regulation
necroptosis
remain
poorly
understood.
The
effects
sestrin2
(SESN2)
overexpression
or
knockdown
were
assessed
in
TNFα/Smac-mimetic/Z-VAD-FMK
(T/S/Z)-induced
model
and
palmitic
acid
(PA)-induced
lipotoxicity
model.
Western-blot,
co-Immunoprecipitation,
Glutathione
S-transferase
pull-down,
confocal
assays
employed
to
explore
regulatory
including
protein-protein
interactions
post-translational
modification.
Furthermore,
we
used
GSK'872,
specific
inhibitor
receptor-interacting
serine/threonine-protein
kinase
(RIPK)
3,
evaluate
relationship
between
SESN2-related
alterations
RIPK3-mediated
T/S/Z-induced
model,
PA-induced
high-fat
high-cholesterol
diet
(HFHCD)-induced
non-alcoholic
steatohepatitis
Our
findings
revealed
that
SESN2
was
upregulated
under
conditions
induce
functioned
as
regulator
necroptosis.
High
levels
could
equipped
hepatocytes
ability
defend
against
necroptotic
inflammation
oxidative
stress.
Mechanistically,
interacted
RIPK3
tuned
down
by
inhibiting
phosphorylation
RIPK3,
promoting
ubiquitination
preventing
formation
RIPK1/RIPK3
necrosome.
depletion
resulted
excessive
accompanied
increased
fat
accumulation,
inflammation,
stress
experimental
Blocking
GSK'872
reduced
liberation
pro-inflammatory
cytokines
reactive
oxygen
species
generation,
but
not
hepatocyte
deposition,
both
PA-treated
knockout
cells
HFHCD-fed
mice,
suggesting
may
partially
account
for
hyperinflammation
induced
deficiency
results
suggested
inhibited
necroptosis;
this
an
important
immune
homeostasis
redox
balance
liver.
Current Opinion in Systems Biology,
Год журнала:
2024,
Номер
39, С. 100519 - 100519
Опубликована: Май 31, 2024
Aberrant
metabolism
and
nutrient
processing
are
hallmarks
in
cancer.
Autophagy
is
a
catabolic
process,
clearing
macromolecules
providing
metabolite
intermediates
for
anabolism.
safeguards
healthy
cells
from
tumorigenesis
while
mobilizing
metabolites
promoting
tumor
growth.
controlled
by
the
mTOR
signaling
network
conjunction
with
AMPK
ULK1.
This
kinase
triad
features
highly
intertwined
feedback
feedforward
mechanisms,
complicating
predictions
on
drug
response.
ODE-based
models
offer
deterministic
approach
frequently
used
exploration
of
dynamics.
Recent
ODE
mTOR-AMPK-ULK1
revealed
non-linear
behaviors,
bistable
switches,
oscillatory
patterns,
shedding
light
robustness
adaptability
autophagy
control.
We
highlight
emerging
perspectives
mTORC1-ULK1
crosstalk
mechanisms
integration
into
future
models.
The European Research Journal,
Год журнала:
2024,
Номер
10(6), С. 634 - 643
Опубликована: Июль 15, 2024
Endometrial
polyps
and
uterine
leiomyomas
are
common
gynecological
conditions
that
significantly
affect
women's
health.
Recent
studies
have
begun
to
explore
potential
biomarkers
could
assist
in
the
early
diagnosis
understanding
of
pathophysiology
these
conditions.
One
such
biomarker
is
Serum
Sestrin
2
(SESN2),
a
protein
involved
cellular
stress
response.
This
review
aims
synthesize
research
findings
on
relationship
between
serum
SESN2
levels
presence
endometrial
leiomyomas.
It
examines
as
diagnostic
tool
its
role
underlying
mechanisms
Studies
suggest
elevated
patients
with
compared
controls,
indicating
involvement
their
pathophysiology.
Furthermore,
discusses
implications
for
clinical
practice,
particularly
terms
detection
targeted
therapies.
Future
directions
need
large-scale
validate
marker
also
addressed.
highlights
importance
like
enhancing
our
management
disorders.
