Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер unknown, С. 101150 - 101150
Опубликована: Ноя. 1, 2024
Язык: Английский
Experimental Hematology and Oncology, Год журнала: 2024, Номер 13(1)
Опубликована: Авг. 30, 2024
Abstract Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is a mechanism that adds different types of ubiquitin chains to proteins, mediating protein degradation or altering their function, thereby affecting cellular signal transduction. Increasing evidence suggests ubiquitination plays crucial role regulating the mechanisms immunotherapy. Drugs targeting pathways have been inhibit tumor progression enhance This review elaborates on by which cells, and microenvironment mediate details how regulates these mechanisms, providing foundation for enhancing intervening modification.
Язык: Английский
Процитировано
5
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 12, 2025
Anaplastic thyroid carcinoma (ATC) is a rare and highly aggressive malignancy characterized by poor prognosis, with median survival time of approximately 3 to 4 months. In this report, we present case involving 59-year-old patient diagnosed ATC, who experienced swift local recurrence pulmonary metastasis following radical thyroidectomy. Comprehensive Sanger sequencing the resected tumor tissue revealed no mutations in TERT promoter or BRAF V600E gene. The exhibited rapid post-surgery was deemed unsuitable for immediate surgical intervention. unable tolerate chemotherapy; therefore, radiotherapy administered initially prevent airway compression resulting from disease progression. During course radiotherapy, developed, yet remained intolerant both chemotherapy anti-angiogenic therapy. Immunohistochemical analysis high expression PD-L1. Whole exome (WES) indicated mutation burden (TMB) 2.98 mut/Mb, microsatellite stability (MSS), identified 10 missense mutations, 1 nonsense mutation, frameshift insertion. However, none these have corresponding targeted therapies. Consequently, tislelizumab as an immunotherapeutic significant regression cervical metastatic lymph nodes tumors, achieving sustained remission lasting 14 months, culminating complete remission, without experiencing any adverse events related immune checkpoint inhibitors. This demonstrates efficacy second-line monotherapy inhibitor (ICI) ATC anlotinib treatment, thereby offering viable treatment strategy patients.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
Neoplasia, Год журнала: 2025, Номер 61, С. 101140 - 101140
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Gene, Год журнала: 2025, Номер unknown, С. 149435 - 149435
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
The Journal of Pathology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Abstract Colorectal cancer (CRC) is the third most common form of globally, and arises from hyperproliferation epithelial cells in intestine. The architecture maintenance these governed by two major signalling pathways working a counter‐gradient: stem cell WNT pathway, prodifferentiation bone morphogenetic protein (BMP) pathway. It has long been known that this WNT‐BMP balance disrupted CRC, with hyperactive leading to increased proliferation tumour progression. BMP signalling, its effects, have increasingly become focus for CRC research. Loss receptors, shown increase CRC. further modulated through secreted antagonists localised intestinal crypts, which create niche ensuring sustained can maintain stem‐cell self‐renewal capacity. A number studies combine demonstrate effects overexpression antagonists, showing hyperactivity stem‐cell‐supporting pathway ensues, deregulation epithelium. Cellular hyperproliferation, emergence ectopic an numbers characteristics are themes, contributing homeostasis, risk progression, resistance therapy. This review aims compile current knowledge on their role development, how we utilise information biomarker research novel therapeutics. © 2025 Author(s). Journal Pathology published John Wiley & Sons Ltd behalf Pathological Society Great Britain Ireland.
Язык: Английский
Процитировано
0
World Journal of Gastrointestinal Oncology, Год журнала: 2024, Номер 16(11), С. 4354 - 4368
Опубликована: Окт. 25, 2024
The relevant mechanism of tumor-associated macrophages (TAMs) in the treatment colorectal cancer patients with immune checkpoint inhibitors (ICIs) is discussed, and application prospects TAMs reversing tolerance ICIs are discussed to provide a reference for related studies. As class drugs widely used clinical tumor immunotherapy, can act on regulatory molecules cells that play an inhibitory role - checkpoints kill tumors form response by activating variety system. sensitivity different types ICI varies greatly. phenotype function microenvironment closely efficacy ICIs. regulate phenotypic TAMs, also affect therapy. important resistance, making full use this target as therapeutic strategy expected improve immunotherapy prognosis cancer.
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер unknown, С. 101150 - 101150
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0