Neuro-Oncology Advances, Год журнала: 2024, Номер 6(1)
Опубликована: Янв. 1, 2024
Glioblastoma (GB) is the most frequent malignant brain tumor and has a dismal prognosis. In other cancers, antibiotic use been associated with severity of chemotherapy-induced toxicity outcome. We investigated if these mechanisms are also involved in GB.
Язык: Английский
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июнь 10, 2024
Glioblastoma (GBM) is a highly malignant, invasive, and poorly prognosed brain tumor. Unfortunately, active comprehensive treatment does not significantly prolong patient survival. With the deepening of research, it has been found that gut microbiota plays certain role in GBM, can directly or indirectly affect efficacy immune checkpoint inhibitors (ICIs) various ways. (1) The metabolites produced by host’s homeostasis, these function distribution cells, promote inhibit inflammatory responses, phenotype, angiogenesis, response, cell infiltration GBM thereby affecting effectiveness ICIs. (2) Some members may reverse T inhibition, increase anti-tumor activity, ultimately improve ICIs targeting specific immunosuppressive cytokines. (3) participate metabolic process drugs, which degrade, transform, produce metabolites, effective concentration bioavailability drugs. Optimizing structure help (4) also regulate status through axis communication, progression therapeutic response to (5) Given importance for ICI therapy, researchers have begun exploring use fecal transplantation (FMT) transplant healthy optimized patients, order their enhance therapy. Preliminary studies suggest FMT therapy some patients. In summary, crucial regulating with deeper understanding relationship between tumor immunity, expected develop more precise personalized strategies prognosis.
Язык: Английский
Процитировано
11
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 27, 2025
Abstract Gliomas are the most common intracranial tumors characterized by highly malignant behavior. In addition to genetic and epigenetic mutations, unique cancer microenvironment (CME) plays a pivotal role in glioma progression resistance therapy. Among critical factors CME, amino acid metabolism stands out for its significant influence, with specific acids suppressing anti‐cancer immune responses promoting an immunosuppressive environment. The human microbiota affect host functions, disruptions homeostasis leading metabolic alterations dysfunction various diseases. Emerging evidence highlights of microbiota‐derived metabolites, including acids, reprogramming CME modulating oncogenic signaling pathways. This review examines influence gut microbiome on metabolism—namely, tryptophan, tyrosine, arginine, branched‐chain acids—and evaluates potential roles microbiome‐derived metabolites prognosis diagnosis glioma.
Язык: Английский
Процитировано
0
Frontiers in Neurology, Год журнала: 2025, Номер 16
Опубликована: Март 21, 2025
Glioma, being one of the malignant tumors with highest mortality rate globally, has an unclear pathogenesis, and existing treatment effects still have certain limitations. The tumor microenvironment (TME) plays important role in occurrence, development, recurrence glioma. As regulatory factors TME, gut microbiota can regulate progression glioma not only by interacting brain through brain-gut axis but also influencing immune (TIME) inflammatory microenvironment. Recent studies identified TME as potential therapeutic targets for This paper aims to summarize association between them glioma, developing new intervention measures targeting microbiota. Understanding involvement process may pave way development effective methods that prevent disease progression.
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2025, Номер 17(7), С. 1228 - 1228
Опубликована: Апрель 4, 2025
Background: The human microbiome plays a crucial role in health and disease. Dysbiosis, an imbalance of microorganisms, has been implicated cancer development treatment response, including primary brain tumors metastases, through interactions mediated by the gut-brain axis. This scoping review synthesizes current evidence on relationship between tumors. Methods: A systematic search five electronic databases was conducted expert librarian, using controlled vocabulary keywords. targeted grey literature Google Scholar clinical trial registries also undertaken. Eligible studies included research involving patients, or vivo, vitro models glioma metastasis, with focus microbiome's tumor development, outcomes. Results: Out 584 citations screened, 40 met inclusion criteria, comprising 24 articles 16 conference abstracts. These 12 studies, mouse models, 7 combining both, 5 employing large datasets next-generation sequencing samples. Thirty-one focused tumors, six three both. Of 20 examining dysbiosis 95% (n = 19) found association growth. Additionally, 71.4% 5/7) reported that alterations influenced efficacy. Conclusions: Although axis is still emerging characterized heterogeneity across existing consistently supports gut both
Язык: Английский
Процитировано
0
Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)
Опубликована: Май 1, 2025
Microbial communities are not simply remnants of the past but dynamic entities that continuously evolve under selective pressures nature, reflecting intricate and adaptive processes evolution. The microbiota residing in various regions human body has numerous roles different physiological such as nutrition, metabolism, immune regulation, etc. In zeal achieving empirical insights into ambit gut microbiome, research over years led to revelation reciprocal interaction between microbiome cognitive functioning body. Dysbiosis microbial composition disturbs homeostatic This dysbiosis been associated with chronic diseases, including brain cancer, glioma, glioblastoma, review explores mechanistic role dysbiosis-mediated progression cancers their subtypes. Moreover, it demonstrates regulatory metabolites produced by microbiota, short-chain fatty acids, amino lipids, etc., tumour progression. Further, we also provide valuable mediating efficiency therapeutic regimens, thereby leveraging potential biomarkers targets for improved treatment outcomes.
Язык: Английский
Процитировано
0
Trends in Molecular Medicine, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
3
Microorganisms, Год журнала: 2024, Номер 12(6), С. 1053 - 1053
Опубликована: Май 23, 2024
Tumors of the central nervous system (CNS) are severe and refractory diseases with poor prognosis, especially for patients malignant glioblastoma brain metastases. Currently, numerous studies have explored potential role bacteria intestinal flora in tumor development treatment. Bacteria can penetrate blood-brain barrier (BBB), targeting hypoxic microenvironment at core tumors, thereby eliminating tumors activating both innate adaptive immune responses, rendering them promising therapeutic agents CNS tumors. In addition, engineered derivatives, such as bacterial membrane proteins spores, also be used good candidate carriers targeted drug delivery. Moreover, regulate metabolism influence through "gut-brain axis". Therefore, anti-tumor therapy, delivery, intervention provide modalities treatment this paper, we performed a comprehensive review mechanisms practices therapy discussed future research directions field.
Язык: Английский
Процитировано
2
MedComm – Oncology, Год журнала: 2024, Номер 3(3)
Опубликована: Авг. 8, 2024
Abstract As the largest microecosystem in human body, gut microbes (GMs) and their metabolites play an important role regulating health. In recent years, immune checkpoint therapy (ICT) combined with antiangiogenic agents is emerging combination for cancer. There growing evidence that GMs can affect effectiveness of drugs to treat not only regulate angiogenesis tumor microenvironment, but also influence efficacy inhibitors. Many studies show Bifidobacterium upregulate anticancer function blockers. addition, have been found be involved formation blood vessels other developmental processes. Clinically, are believed a key patients receiving ICT. this perspective, we provide overview composition microbiome, discuss against conditioning angiogenic We summarize new approaches clinical translational trials using cancer therapy, present opportunities challenges targeting future.
Язык: Английский
Процитировано
0
Neuro-Oncology Advances, Год журнала: 2024, Номер 6(1)
Опубликована: Янв. 1, 2024
Glioblastoma (GB) is the most frequent malignant brain tumor and has a dismal prognosis. In other cancers, antibiotic use been associated with severity of chemotherapy-induced toxicity outcome. We investigated if these mechanisms are also involved in GB.
Язык: Английский
Процитировано
0