International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9294 - 9294
Опубликована: Авг. 27, 2024
Bacterial
and
fungal
superinfections
are
common
in
COVID-19,
early
diagnosis
can
enable
timely
intervention.
Serum
calprotectin
levels
increase
with
bacterial,
fungal,
viral
infections.
This
study
evaluated
serum
as
a
diagnostic
prognostic
tool
for
microbial
COVID-19.
samples
from
adult
patients
moderate
severe
COVID-19
were
collected
during
hospitalization
2020
to
2024.
Calprotectin
measured
using
an
enzyme-linked
immunosorbent
assay
63
60
34
healthy
individuals.
elevated
compared
controls,
these
further
increased
the
cases.
Patients
vancomycin-resistant
enterococci
(VRE)
bacteremia
had
levels,
but
their
C-reactive
protein
procalcitonin
not
increased.
Fungal
herpes
simplex
virus
reactivation
did
change
levels.
A
concentration
of
31.29
µg/mL
be
used
diagnose
VRE
bloodstream
infection
60%
sensitivity
96%
specificity.
These
data
suggest
that
may
promising
biomarker
detection
infections
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Abstract
Background
Recent
studies
have
indicated
that
copper
overload
(CPO)
has
cytotoxic
effects,
and
metallothionein
2A
(MT2A)
a
high
affinity
for
metal
ions.
However,
it
is
unclear
whether
MT2A
can
normalize
endothelial
cell
(EC)
proliferation
angiogenesis
in
chronically
ischemic
brains
by
neutralizing
excessive
ions
during
CPO.
Methods
Dura
matter
(DM)
samples
from
patients
with
chronic
cerebrovascular
disease
were
collected,
the
expression
of
cuproptosis-related
genes
(DLAT,
FDX1
SDHB)
was
determined.
CPO
human
umbilical
vein
cells
(HUVECs)
induced
elesclomol
CuCl2.
HUVEC
activity
under
hypoxia
structure
function
mitochondria
compared
among
groups
different
ion
concentrations
levels.
Furthermore,
rat
model
2-vessel
occlusion
plus
encephalo-myo-synangiosis
(2VO
+
EMS)
established
to
explore
ability
promote
through
copper–mitochondria
regulatory
mechanism
brains.
Results
Compared
those
Matsushima
grade
A
patients,
DM
C
presented
significantly
greater
DLAT
lower
SDHB
expression.
decreased
group.
oligomerization
increased
Mitochondrial
aberrations
more
common
mitochondrial
group
than
control
overexpression
alleviated
impairment
dysfunction
In
vivo,
inhibited
cerebral
2VO
EMS
rats.
CD31
CPOMT2A+
accumulation
less
Less
swelling
fewer
vacuoles
observed
Cerebral
blood
perfusion
(CBP)
performance
Morris
water
maze
test
better
Conclusion
inhibits
EC
impairing
function,
whereas
promotes
rescuing
function.
Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1550 - 1550
Опубликована: Дек. 4, 2024
Since
its
discovery
in
1992,
the
receptor
for
advanced
glycation
end
products
(RAGE)
has
emerged
as
a
key
many
pathological
conditions,
especially
inflammatory
conditions.
RAGE
is
expressed
by
most,
if
not
all,
immune
cells
and
can
be
activated
ligands.
One
characteristic
of
that
ligands
are
structurally
very
diverse
belong
to
different
classes
molecules,
making
promiscuous
receptor.
Many
damaged
associated
molecular
patterns
(DAMPs)
released
under
Although
been
at
center
lot
research
past
three
decades,
clear
understanding
mechanisms
activation
still
missing.
In
this
review,
we
summarize
current
knowledge
role
inflammation.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9294 - 9294
Опубликована: Авг. 27, 2024
Bacterial
and
fungal
superinfections
are
common
in
COVID-19,
early
diagnosis
can
enable
timely
intervention.
Serum
calprotectin
levels
increase
with
bacterial,
fungal,
viral
infections.
This
study
evaluated
serum
as
a
diagnostic
prognostic
tool
for
microbial
COVID-19.
samples
from
adult
patients
moderate
severe
COVID-19
were
collected
during
hospitalization
2020
to
2024.
Calprotectin
measured
using
an
enzyme-linked
immunosorbent
assay
63
60
34
healthy
individuals.
elevated
compared
controls,
these
further
increased
the
cases.
Patients
vancomycin-resistant
enterococci
(VRE)
bacteremia
had
levels,
but
their
C-reactive
protein
procalcitonin
not
increased.
Fungal
herpes
simplex
virus
reactivation
did
change
levels.
A
concentration
of
31.29
µg/mL
be
used
diagnose
VRE
bloodstream
infection
60%
sensitivity
96%
specificity.
These
data
suggest
that
may
promising
biomarker
detection
infections
