Oxidative photocatalysis on membranes triggers non-canonical pyroptosis DOI Creative Commons
Chaiheon Lee, Mingyu Park,

W.C. Bhashini Wijesinghe

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Май 13, 2024

Abstract Intracellular membranes composing organelles of eukaryotes include membrane proteins playing crucial roles in physiological functions. However, a comprehensive understanding the cellular responses triggered by intracellular membrane-focused oxidative stress remains elusive. Herein, we report an amphiphilic photocatalyst localised to damage oxidatively, resulting non-canonical pyroptosis. Our developed photocatalysis generates hydroxyl radicals and hydrogen peroxides via water oxidation, which is accelerated under hypoxia. Single-molecule magnetic tweezers reveal that photocatalysis-induced oxidation markedly destabilised protein folding. In cell environment, label-free quantification reveals occurs primarily related quality control, thereby aggravating mitochondrial endoplasmic reticulum inducing lytic death. Notably, activates inflammasome caspases, gasdermin D cleavage its pore-forming fragment subsequent These findings suggest triggers

Язык: Английский

Targeting ROS in cancer: rationale and strategies DOI
Christophe Glorieux, Shihua Liu, Dunyaporn Trachootham

и другие.

Nature Reviews Drug Discovery, Год журнала: 2024, Номер 23(8), С. 583 - 606

Опубликована: Июль 9, 2024

Язык: Английский

Процитировано

152
mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy DOI Creative Commons
Fengqiao Li, Xue‐Qing Zhang, William Ho

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Июль 15, 2023

Synergistically improving T-cell responsiveness is promising for favorable therapeutic outcomes in immunologically cold tumors, yet current treatments often fail to induce a cascade of cancer-immunity cycle effective antitumor immunity. Gasdermin-mediated pyroptosis newly discovered mechanism cancer immunotherapy; however, cleavage the N terminus required activate pyroptosis. Here, we report single-agent mRNA nanomedicine-based strategy that utilizes lipid nanoparticles (LNPs) encoding only N-terminus gasdermin trigger pyroptosis, eliciting robust In multiple female mouse models, show pyroptosis-triggering mRNA/LNPs turn tumors into hot ones and create positive feedback loop promote Additionally, mRNA/LNP-induced sensitizes anti-PD-1 immunotherapy, facilitating tumor growth inhibition. Antitumor activity extends beyond treated lesions suppresses distant tumors. We implement inducing potent immunity, enhancing immunotherapy responses

Язык: Английский

Процитировано

71
Engineered Bacteria Labeled with Iridium(III) Photosensitizers for Enhanced Photodynamic Immunotherapy of Solid Tumors DOI

Wenkai Lin,

Yu Liu, Jinhui Wang

и другие.

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(43)

Опубликована: Сен. 5, 2023

Despite metal-based photosensitizers showing great potential in photodynamic therapy for tumor treatment, the application of is intrinsically limited by their poor cancer-targeting properties. Herein, we reported a photosensitizer-bacteria hybrid, Ir-HEcN, via covalent labeling an iridium(III) photosensitizer to surface genetically engineered bacteria. Due its intrinsic self-propelled motility and hypoxia tropism, Ir-HEcN selectively targets penetrates deeply into tissues. Importantly, capable inducing pyroptosis immunogenic cell death cells under irradiation, thereby remarkably evoking anti-tumor innate adaptive immune responses vivo leading regression solid tumors combinational immunotherapy. To best our knowledge, first metal complex decorated bacteria enhanced

Язык: Английский

Процитировано

52
Role of pyroptosis in the pathogenesis and treatment of diseases DOI Creative Commons
Xiangyu Jin, Yinchu Ma, Didi Liu

и другие.

MedComm, Год журнала: 2023, Номер 4(3)

Опубликована: Апрель 25, 2023

Abstract Programmed cell death (PCD) is regarded as a pathological form of with an intracellular program mediated, which plays pivotal role in maintaining homeostasis and embryonic development. Pyroptosis new paradigm PCD, has received increasing attention due to its close association immunity disease. inflammatory mediated by gasdermin that promotes the release proinflammatory cytokines contents induced inflammasome activation. Recently, evidence studies shows pyroptosis crucial conditions like cardiovascular diseases (CVDs), cancer, neurological (NDs), metabolic (MDs), suggesting targeting potential intervention for treatment these diseases. Based on this, review aims identify molecular mechanisms signaling pathways related activation summarizes current insights into complicated relationship between multiple human (CVDs, NDs, MDs). We also discuss promising novel strategy method treating focus pathway application clinics.

Язык: Английский

Процитировано

33
Quinoxaline derivatives: Recent discoveries and development strategies towards anticancer agents DOI Creative Commons
Vincent Montero, Marc Montana, Manon Carré

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 271, С. 116360 - 116360

Опубликована: Апрель 7, 2024

Cancer is a leading cause of death and major health problem worldwide. While many effective anticancer agents are available, most drugs currently on the market not specific, raising issues like common side effects chemotherapy. However, recent research hold promises for development more efficient safer drugs. Quinoxaline its derivatives becoming recognized as novel class chemotherapeutic with activity against different tumors. The present review compiles discusses studies concerning therapeutic potential quinoxaline derivatives, covering articles published between January 2018 2023.

Язык: Английский

Процитировано

10
Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death DOI

Fangxue Du,

Hongxin Zhao,

Yangmeihui Song

и другие.

Advanced Functional Materials, Год журнала: 2024, Номер 34(44)

Опубликована: Май 25, 2024

Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.

Язык: Английский

Процитировано

10
Mitochondria and cell death signalling DOI Creative Commons

Ella Hall-Younger,

Stephen W.G. Tait

Current Opinion in Cell Biology, Год журнала: 2025, Номер 94, С. 102510 - 102510

Опубликована: Апрель 11, 2025

Язык: Английский

Процитировано

2
Molecular mechanisms of pyroptosis and its role in anti-tumor immunity DOI Creative Commons

Hongyong Huang,

Yanmin Weng,

Wen Tian

и другие.

International Journal of Biological Sciences, Год журнала: 2023, Номер 19(13), С. 4166 - 4180

Опубликована: Янв. 1, 2023

Pyroptosis is a form of cell death that characterized by the destruction cell, and it has implications in both immune system cancer immunotherapy.The gasdermin family responsible for activation pyroptosis, which involves formation pores cellular membrane permit discharge inflammatory factors.The inflammasome response powerful mechanism helps to eliminate bacteria cells when damage occurs.As tumor become more resilient apoptosis, other treatments are becoming popular.It essential gain thorough understanding pyroptosis order use treatment, considering intricate association between system's defensive reaction against tumors.This review offers an overview mechanisms relationship interplay anti-tumor immunity.In addition, potential immunotherapy discussed.Additionally, we explore future research possibilities introduce novel approach treatment.

Язык: Английский

Процитировано

20
Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review DOI Creative Commons
Leonardo de Oliveira Siquara da Rocha, Éverton Freitas de Morais, Lilianny Querino Rocha de Oliveira

и другие.

Biology, Год журнала: 2024, Номер 13(2), С. 103 - 103

Опубликована: Фев. 6, 2024

Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head neck cancer in world. Variable response acquisition resistance to traditional therapies show that it essential develop novel strategies can provide better outcomes for patient. Understanding cellular molecular mechanisms death control has increased rapidly recent years. Activation pathways, such as emerging forms non-apoptotic programmed death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis paraptosis, may represent clinically relevant therapeutic opportunities. This systematic review summarizes recently described OSCC, highlighting their potential informing diagnosis, prognosis treatment. Original studies explored any selected deaths OSCC were included. Electronic search, study selection, data collection risk bias assessment tools realized. The literature search was carried out four databases, extracted from 79 articles categorized grouped by death. Ferroptosis, necroptosis represented main studies, with links immunity inflammatory responses, progression OSCC. Harnessing these pathways be useful patient-specific individualized therapy. We perspectives on how different types integrated decision prognosis, treatment

Язык: Английский

Процитировано

8
Crosstalk between hypoxia-induced pyroptosis and immune escape in cancer: From mechanisms to therapy DOI Creative Commons
Seyed Mohammadmahdi Meybodi, Mahsa Ejlalidiz,

Mohammadsadegh Rezaeian Manshadi

и другие.

Critical Reviews in Oncology/Hematology, Год журнала: 2024, Номер 197, С. 104340 - 104340

Опубликована: Апрель 1, 2024

Pyroptosis can be triggered through both canonical and non-canonical inflammasome pathways, involving the cleavage of gasdermin (GSDM) protein family members, like GSDMD GSDME. The impact pyroptosis on tumors is nuanced, because its role in regulating cancer progression anti-tumor immunity may vary depending tumor type, stage, location, immune status. However, cannot simply categorized as promoting or inhibiting based solely whether it acute chronic nature. interplay between intricate, with some evidence suggesting that facilitate growth, while induction could stimulate anti-cancer responses. Tumor hypoxia activates inducible factor (HIF) signaling to modulate checkpoint expression. Targeting this hypoxia-pyroptosis-immune escape axis a promising therapeutic strategy. This review highlights complex crosstalk hypoxia, pyroptosis, evasion TME.

Язык: Английский

Процитировано

7