Emerging Insights: miRNA Modulation of Ferroptosis Pathways in Lung Cancer

Experimental Cell Research, Год журнала: 2024, Номер 442(2), С. 114272 - 114272

Опубликована: Окт. 1, 2024

Язык: Английский

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Discovery of Lipoxygenase-Like Materials for Inducing Ferroptosis

ACS Nano, Год журнала: 2024, Номер 18(47), С. 32438 - 32450

Опубликована: Ноя. 12, 2024

Recent research has highlighted the pivotal role of lipoxygenases in modulating ferroptosis and immune responses by catalyzing generation lipid peroxides. However, limitations associated with protein enzymes, such as poor stability, low bioavailability, high production costs, have motivated researchers to explore biomimetic materials lipoxygenase-like activity. Here, we report discovery two-dimensional (2D) MoS

Язык: Английский

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Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Язык: Английский

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Downregulation of AATK enhances susceptibility to ferroptosis by promoting endosome recycling in gefitinib‐resistant lung cancer cells

The Journal of Pathology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Abstract Ferroptosis has been characterised by disruption of the cell membrane through iron‐related lipid peroxidation. However, regulation iron homeostasis in lung cancer cells that are resistant to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) remains unclear. Transcriptome analysis identified a significant downregulation apoptosis‐associated ( AATK ) mRNA expression gefitinib‐resistant PC9 (PC9‐GR) cells, which were found be more susceptible ferroptosis inducers. An in‐depth publicly available datasets revealed was associated with lymph node metastasis and poor prognosis patients adenocarcinoma. Knockdown AATK‐sensitised PC9, HCC827, H441 inducer RSL3, whereas ectopic reduced RSL3‐induced death PC9‐GR HCC827‐GR cells. Compared exhibited higher transferrin uptake, endosome recycling rate, increased intracellular levels. Blocking transport Mechanistic studies showed localised both early endosomes. facilitated elevated ferrous (Fe 2+ levels Conversely, delayed Fe Inhibition downregulation‐induced accumulation decreased ferroptosis. Taken together, our study indicates contributes accumulation, leading an susceptibility EGFR‐TKI‐resistant © 2025 The Pathological Society Great Britain Ireland.

Язык: Английский

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Bibliometric analysis of ferroptosis: a comprehensive evaluation of its contribution to lung cancer

Frontiers in Genetics, Год журнала: 2025, Номер 15

Опубликована: Янв. 29, 2025

Objectives This study employs bibliometric analysis to track evolution and identify trends of key topics in ferroptosis within the context lung cancer. By identifying emerging research areas, our aim is provide valuable insights directions for researchers this field. Methods Relevant papers reviews on cancer were retrieved from Web Science Core Collection database 5 February 2024. Bibliometric was conducted using CiteSpace 6.2.R3, VOSviewer 1.6.20, R 4.3.0, Microsoft Excel 2019. Results From 2015 2020, publications related sparse but showed a steady increase. Post-2020, there has been significant surge, with 6.4-fold increase observed by 2023. Overall, authors 4,033 institutions across 42 countries/regions contributed 606 published 262 academic journals. China emerged as leading contributor, while United States maintained dominance. Lifang Ma most prolific author, DIXON SJ, YANG WS, STOCKWELL BR being frequently co-cited. Effective communication collaboration among scholars are lacking. Key journals include Frontiers Pharmacology publication output, Nature Cell citation frequency. Research focuses molecular mechanisms ferroptosis, including endoplasmic reticulum stress, tumor microenvironment, autophagy. Therapeutic targets like GPX4, SLC7A11, P53, FSP1, Nrf2, LSH, STYK1/NOK, ACSL4 prominent. Traditional Chinese medicine also shows clinical value research. Conclusion Ferroptosis, promising avenue applications cancer, continues undergo rapid development. The iron death will remain critical focus future.

Язык: Английский

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Herbal Formula Yi‐Fei‐Jie‐Du‐Tang Regulates Epithelial‐Mesenchymal Transition and Vasculogenic Mimicry in Lung Cancer via HIF1A‐Mediated Ferroptosis

Advanced Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Traditional Chinese medicine (TCM) Yi-Fei-Jie-Du-Tang (YFJDT) has shown potential in lung cancer treatment. However, the mechanisms underlying effects of YFJDT on remain unclear. Bioinformatics analysis is conducted to identify targets YFJDT. The impact hypoxia-inducible factor 1 alpha (HIF1A), ferroptosis, and vasculogenic mimicry (VM) investigated using xenograft tumor models A549 cells. Additionally, cells are stimulated with CoCl2 mimic hypoxic microenvironment tumor. role HIF1A overexpression modulating ferroptosis assessed. epithelial-mesenchymal transition (EMT) VM vitro evaluated. Results: treatment led a concentration-dependent decrease levels tumors Overexpression counteractes inhibitory proliferation, EMT, transplanted tumors. Moreover, attenuates YFJDT-induced lipid peroxidation iron accumulation, indicating inhibition Hypoxia-induced alterations EMT markers reversed by but exacerbated overexpression. Molecular docking identified salicylic acid psoralen as components targeting HIF1A. exerts anti-tumor downregulating promoting ferroptosis.

Язык: Английский

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Advances in understanding ferroptosis mechanisms and their impact on immune cell regulation and tumour immunotherapy

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 10, 2025

Ferroptosis is a novel mode of iron-dependent non-apoptotic cell death that occurs mainly due to excessive accumulation lipid peroxides. Numerous studies in recent years have shown ferroptosis plays vital role the organism and has important interactions with immune cells. been great potential tumour therapy through studying its mechanism action. In addition, major many types cells can potently suppress tumourigenesis metastasis, provide basis for treatment malignant diseases become therapeutic modality antitumour immunity clinic. Current immunotherapy combination other conventional oncological modalities not well elaborated. this paper, we discuss connection their mediated order better theoretical new thinking about immunity.

Язык: Английский

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Ferroptosis in Pulmonary Disease and Lung Cancer: Molecular Mechanisms, Crosstalk Regulation, and Therapeutic Strategies

MedComm, Год журнала: 2025, Номер 6(3)

Опубликована: Фев. 23, 2025

Ferroptosis is a distinct form of iron-dependent programmed cell death characterized primarily by intracellular iron accumulation and lipid peroxidation. Multiple cellular processes, including amino acid metabolism, various signaling pathways, autophagy, have been demonstrated to influence the induction progression ferroptosis. Recent investigations elucidated that ferroptosis plays crucial role in pathogenesis pulmonary disorders, lung injury, chronic obstructive disease, fibrosis, asthma. increasingly recognized as promising novel strategy for cancer treatment. Various immune cells within tumor microenvironment, CD8+ T cells, macrophages, regulatory natural killer dendritic shown induce modulate process through regulation metabolism pathways. Conversely, can reciprocally alter metabolic environment, leading activation or inhibition functions, thereby modulating responses. This paper reviews molecular mechanism describes discusses connection between microenvironment diseases, development prospect their interaction treatment diseases.

Язык: Английский

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Identification of potential biomarkers for lung cancer using integrated bioinformatics and machine learning approaches

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0317296 - e0317296

Опубликована: Фев. 27, 2025

Lung cancer is one of the most common and leading cause cancer-related death worldwide. Early detection lung can help reduce rate; therefore, identification potential biomarkers crucial. Thus, this study aimed to identify for by integrating bioinformatics analysis machine learning (ML)-based approaches. Data were normalized using robust multiarray average method batch effect corrected ComBat method. Differentially expressed genes identified LIMMA approach carcinoma-associated selected Enrichr, based on DisGeNET database. Protein-protein interaction (PPI) network was performed STRING, PPI visualized Cytoscape. The core hub overlapping obtained from degree, betweenness, closeness, MNC. Moreover, MCODE plugin Cytoscape used perform module analysis, optimal modules scores along with their associated genes. Subsequently, Boruta-based ML utilized important Consequently, networks, ML-based approach. prognostic discriminative power assessed through survival ROC analysis. We extracted five datasets USA cohort three Taiwan same experimental protocols determine biomarkers. Four ( LPL, CLDN18, EDNRB, MME ) cohort, while DNRB, MME, ROBO4 cohort. Finally, two EDNRB intersecting genes, cohorts. proposed significantly improve patient outcomes enabling earlier detection, precise diagnosis, tailored treatment, ultimately contributing better rates quality life patients.

Язык: Английский

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Interplay Between Traditional and Scientific Knowledge: Phytoconstituents and Their Roles in Lung and Colorectal Cancer Signaling Pathways

Biomolecules, Год журнала: 2025, Номер 15(3), С. 380 - 380

Опубликована: Март 5, 2025

Natural plant products have been used for cancer treatment since ancient times and continue to play a vital role in modern anticancer drug development. However, only small fraction of identified medicinal plants has thoroughly investigated, particularly their effects on cellular pathways lung colorectal cancers, two under-researched cancers with poor prognostic outcomes (lung cancers). This review focuses the signaling modulated by bioactive compounds from eleven traditional plants: Curcuma longa, Astragalus membranaceus, Glycyrrhiza glabra, Althaea officinalis, Echinacea purpurea, Sanguinaria canadensis, Codonopsis pilosula, Hydrastis Lobelia inflata, Scutellaria baicalensis, Zingiber officinale. These were selected based documented use medicine clinical practice. Selection criteria involved cross-referencing herbs scoping treatments findings an international survey herbal currently management our research group availability existing literature properties. The identifies several isolated phytoconstituents these that exhibit properties modulating key such as PI3K/Akt/mTOR, RAS/RAF/MAPK, Wnt/β-catenin, TGF-β vitro. Notable constituents include sanguinarine, berberine, hydrastine, lobeline, curcumin, gingerol, shogaol, caffeic acid, echinacoside, cichoric glycyrrhizin, 18-β-glycyrrhetinic astragaloside IV, lobetyolin, licochalcone A, baicalein, baicalin, wogonin, glycyrol. Curcumin baicalin show preclinical effectiveness but face bioavailability challenges, which may be overcome combining them piperine or using oral extracts enhance gut microbiome conversion, integrating knowledge strategies improved outcomes. Furthermore, Echinacea, Glycyrrhiza, Codonopsis, knowledge, are trials. Notably, curcumin also modulate miRNA pathways, highlighting promising intersection science medicine. Thus, development therapeutics continues benefit synergy scientific innovation, technological advancements.

Язык: Английский

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