Proposal for targeted, neo-evolutionary-oriented secondary prevention of early-onset endometriosis and adenomyosis. Part II: medical interventions

Human Reproduction, Год журнала: 2023, Номер 39(1), С. 18 - 34

Опубликована: Ноя. 10, 2023

According to consistent epidemiological data, the slope of incidence curve endometriosis rises rapidly and sharply around age 25 years. The delay in diagnosis is generally reported be between 5 8 years adult women, but it appears over 10 adolescents. If this true, actual onset many young women would chronologically placed early postmenarchal Ovulation menstruation are inflammatory events that, when occurring repeatedly for years, may theoretically favour development adenomyosis. Moreover, repeated acute dysmenorrhoea episodes after menarche not only an indicator ensuing or adenomyosis, also promote transition from chronic pelvic pain through central sensitization mechanisms, as well overlapping conditions. Therefore, secondary prevention aimed at reducing suffering, limiting lesion progression, preserving future reproductive potential should focused on group that could benefit most intervention, i.e. severely symptomatic Early-onset adenomyosis promptly suspected even physical ultrasound findings negative, long-term ovulatory suppression established until conception seeking. As nowadays mean using hormonal therapies several drug safety evaluation crucial. In adolescents without recognized major contraindications oestrogens, use very low-dose combined oral contraceptives associated with a marginal increase individual absolute risk thromboembolic events. Oral containing oestradiol instead ethinyl further limit such risk. Oral, subcutaneous, intramuscular progestogens do risk, interfere attainment peak bone mass women. Levonorgestrel-releasing intra-uterine devices safe alternative adolescents, amenorrhoea frequently induced ovarian activity. With regard oncological net effect oestrogen-progestogen combinations small reduction overall cancer Whether surgery considered first-line approach symptoms seems questionable. Especially large endometriomas infiltrating lesions detected imaging, laparoscopy reserved who refuse treatments whom medications effective, tolerated, contraindicated. Diagnostic therapeutic algorithms, including self-reported outcome measures, individuals clinical suspicion early-onset proposed.

Язык: Английский

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Proposal for targeted, neo-evolutionary-oriented, secondary prevention of early-onset endometriosis and adenomyosis. Part I: pathogenic aspects

Human Reproduction, Год журнала: 2023, Номер 39(1), С. 1 - 17

Опубликована: Ноя. 10, 2023

Abstract The potential for repeated ovulation and menstruation is thought to have provided a Darwinian advantage during the Palaeolithic. Reproductive conditions remained relatively stable until pre-industrial era, characterized by late menarche, very young age at first birth, multiple pregnancies, prolonged periods of lactational amenorrhoea. For hundreds thousands years, menstruators experienced few ovulatory cycles, even though they were genetically adapted ovulate menstruate every month. In post-industrial menarche gradually declined, birth progressively increased, breastfeeding became optional often short duration. This created mismatch between genetic adaptation socio-environmental evolution, so that what was initially probable reproductive subsequently contributed increased susceptibility diseases associated with lifetime oestrogen exposure, such as ovarian, endometrial breast cancer and, hypothetically, also those number menstruations, endometriosis adenomyosis. incidence shows steep progressive increase around 25 but given consistently reported delay in diagnosis, actual curve should be shifted left, supporting possibility disease has its roots adolescence. raises question whether, from an evolutionary point view, anovulation amenorrhoea not still considered physiological state, especially postmenarchal period. However, frequency recent decades been demonstrated, although this deserves further epidemiological investigation. addition, occurs minority individuals exposed retrograde menstruation, other important pathogenic factors scrutinised. Research resumed explore more detail transtubal reflux only blood, cells, whether are systematically present peritoneal fluid after menstruation. If repetitive early years shown risk adenomyosis development progression susceptible individuals, hormonal interventions could used secondary prevention symptomatic adolescents.

Язык: Английский

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Rapid screening of infertility-associated gynecological conditions via ambient glow discharge mass spectrometry utilizing urine metabolic fingerprints

Talanta, Год журнала: 2024, Номер 274, С. 125969 - 125969

Опубликована: Апрель 8, 2024

Язык: Английский

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A transcriptomic analysis of the interplay of ferroptosis and immune filtration in endometriosis and identification of novel therapeutic targets

Computational Biology and Chemistry, Год журнала: 2025, Номер 115, С. 108343 - 108343

Опубликована: Янв. 7, 2025

Язык: Английский

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β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the MAPK and STAT3 signaling pathways

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119344 - 119344

Опубликована: Янв. 1, 2025

Язык: Английский

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Silencing of FZD7 Inhibits Endometriotic Cell Viability, Migration, and Angiogenesis by Promoting Ferroptosis

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Язык: Английский

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New insights into the ferroptosis and immune infiltration in endometriosis: a bioinformatics-based analysis

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 13, 2025

Ferroptosis, a recently discovered iron-dependent cell death, is linked to various diseases but its role in endometriosis still not fully understood. In this study, we integrated microarray data of from the GEO database and ferroptosis-related genes (FRGs) FerrDb further investigate regulation ferroptosis impact on immune microenvironment. WGCNA identified modules, annotated by GO & KEGG. MNC algorithm pinpointed hub FRGs. Cytoscape construct ceRNA network, ROC curves evaluated diagnostic efficacy Consensus cluster analysis subclusters, CIBERSORT assessed infiltration these subclusters. Finally, RT-qPCR validated FRG expression clinical tissues. We two modules endometriosis, enrichment analysis, they are closely with autophagy, mTOR, oxidative stress, FOXO pathways. Furthermore, 10 FRGs, curve showed better predictive ability for diagnosing. confirmed that tissue FRGs was mostly consistent results. Subsequently, developed network based 4 (BECN1, OSBPL9, TGFBR1, GSK3B). Next, subclusters stage. Importantly, illustrated levels cells checkpoint were significantly different Specifically, subcluster stage III-IV more inclined immunosuppressive Our study may jointly promote progression remodeling microenvironment, offering new insights into pathogenesis therapeutics.

Язык: Английский

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Ferroptosis in Endometriosis: Traditional Chinese Medicine Interventions and Mechanistic Insights

The American Journal of Chinese Medicine, Год журнала: 2025, Номер unknown, С. 1 - 24

Опубликована: Март 27, 2025

Endometriosis (EMS) is a chronic, estrogen-dependent inflammatory disease affecting 5–10% of women reproductive age, characterized by the growth endometrial tissue on outside uterus. The dysregulation iron metabolism leads to accumulation ions at lesion sites, resulting in oxidative stress and pro-inflammatory responses that promote progression EMS. mechanisms underlying ferroptosis EMS primarily involve accumulation, lipid peroxidation, loss glutathione peroxidase 4 activity. These confer resistance within ectopic tissues facilitate cell survival proliferation. Traditional Chinese medicine (TCM) has demonstrated therapeutic potential for modulating ferroptosis. Studies have shown TCM monomers may regulate transport proteins anti-oxidant defense mechanisms. formulas employ distinct treatment strategies depending stage EMS: early stages, they control growth, whereas later inhibit reduce inflammation order improve health slow progression. This study provides new perspective management summarizing role its pathological reviewing findings use regulating

Язык: Английский

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Is retrograde menstruation a universal, recurrent, physiological phenomenon? A systematic review of the evidence in humans and non-human primates

Human Reproduction Open, Год журнала: 2024, Номер 2024(3)

Опубликована: Янв. 1, 2024

What are the quantitative, qualitative, and temporal patterns of retrograde mentruation?

Язык: Английский

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Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP

Advanced Science, Год журнала: 2024, Номер 11(38)

Опубликована: Авг. 9, 2024

Abstract Endometriosis, a chronic inflammatory disease, significantly impairs the quality of life women in their reproductive years; however, its pathogenesis remains poorly understood. The accumulation retrograde menstruation and recurrent bleeding fosters high‐iron environment ectopic lesions, triggering ferroptosis endometrial stromal cells (EESCs), thereby hindering establishment endometriosis. However, abnormal EESCs demonstrate resistance to environments, promoting progression this disease. Here, novel findings on creatine, derived from endogenous synthesis, both peritoneal fluid patients with endometriosis are presented. Creatine supplementation reduces cellular iron concentrations, mitigating oxidative stress lipid peroxidation, enhancing cell viability preventing under conditions. Utilizing drug affinity–responsive target stabilization (DARTS) assay, prion protein (PrP) as potential creatine‐sensing is identified. Mechanistically, creatine binds active site PrP, inhibits conversion trivalent divalent iron, decreases uptake, tolerance ferroptosis. This interaction contributes development association between provides valuable insights into role highlights therapeutic for

Язык: Английский

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