Bacterial Systems as a Precision Delivery Platform of Therapeutic Peptides for Cancer Therapy
Polymer science & technology.,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Язык: Английский
Propagation of a rapid cell-to-cell H2O2 signal over long distances in a monolayer of cardiomyocyte cells
Redox Biology,
Год журнала:
2024,
Номер
70, С. 103069 - 103069
Опубликована: Фев. 9, 2024
Cell-to-cell
communication
plays
a
cardinal
role
in
the
biology
of
multicellular
organisms.
H
Язык: Английский
Unraveling the molecular mechanism underlying the anticancer activity of CISD2/NAF-144-67
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 8, 2025
We
recently
reported
on
the
development
of
a
unique
cancer-targeting
peptide
called
NAF-1
44-67
(derived
from
CISD2/NAF-1).
selectively
permeates
plasma
membrane
(PM)
cancer
cells,
but
not
healthy
causing
activation
apoptotic
and
ferroptotic
cell
death
pathways
specifically
in
cells.
also
targets
shrinks
human
breast
ovarian
tumors
xenograft
mice
model
system
without
any
apparent
side
effects.
Although
specific
permeation
through
PMs
was
studied,
its
killing
effects
validated
vitro
vivo
,
little
is
known
about
how
exerts
biological
activity
once
it
enters
Here,
we
report
that
CISD2/NAF-1
protein
cells
disrupts
homodimeric
structure.
further
reveal
derived
same
domain
CISD1
(mitoNEET;
mNT
19-42
)
protein,
close
family
member
to
CISD2,
has
no
towards
dimers
(at
two
different
orientations)
have
higher
anticancer
compared
monomeric
.
Our
findings
shed
new
light
bring
closer
becoming
potential
drug.
Язык: Английский
Unraveling the molecular mechanism underlying the anticancer activity of CISD2/NAF-144-67
Cancer Letters,
Год журнала:
2025,
Номер
unknown, С. 217644 - 217644
Опубликована: Март 1, 2025
Язык: Английский
Peptides in Breast Cancer Therapy: From Mechanisms to Emerging Drug Delivery and Immunotherapy Strategies
Pathology - Research and Practice,
Год журнала:
2025,
Номер
unknown, С. 155946 - 155946
Опубликована: Март 1, 2025
Язык: Английский
Propagation of a rapid cell-to-cell H2O2signal over long distances in a monolayer of cardiomyocyte cells
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 19, 2023
Cell-to-cell
communication
plays
a
cardinal
role
in
the
biology
of
multicellular
organisms.
H
Язык: Английский