Targeting tumor-associated macrophages in colon cancer: mechanisms and therapeutic strategies
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 21, 2025
Colon
cancer
(CC)
remains
a
primary
contributor
to
cancer-related
fatalities
worldwide,
driven
by
difficulties
in
early
diagnosis
and
constrained
therapeutic
options.
Recent
studies
underscore
the
importance
of
tumor
microenvironment
(TME),
notably
tumor-associated
macrophages
(TAMs),
fostering
malignancy
progression
therapy
resistance.
Through
their
inherent
plasticity,
TAMs
facilitate
immunosuppression,
angiogenic
processes,
metastatic
spread,
drug
tolerance.
In
contrast
M1
macrophages,
which
promote
inflammatory
tumoricidal
responses,
M2
support
expansion
dissemination
exerting
immunosuppressive
pro-angiogenic
influences.
Consequently,
manipulating
has
emerged
as
potential
avenue
enhance
treatment
effectiveness.
This
review
outlines
origins,
polarization
states,
functions
CC,
highlights
role
driving
advancement,
surveys
ongoing
efforts
target
these
cells
for
better
patient
outcomes.
Emerging
strategies
aimed
at
modulating
TAM
-
including
depletion
strategies,
reprogramming
approaches
that
shift
M2-polarized
toward
an
phenotype,
inhibition
key
signaling
pathways
sustaining
TAM-mediated
immunosuppression-are
currently
under
active
investigation.
These
hold
promise
overcoming
induced
resistance
improving
immunotherapeutic
efficacy
CC.
Язык: Английский
The role of Treg cells in colorectal cancer and the immunotherapy targeting Treg cells
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 16, 2025
Colorectal
cancer
(CRC)
is
among
the
most
prevalent
and
lethal
cancers
globally,
accounting
for
approximately
10%
of
all
cases
deaths.
Regulatory
T
(Treg)
cells,
which
accumulate
in
CRC
tissue,
suppress
anti-tumor
immune
responses
facilitate
tumor
progression.
This
review
discusses
Treg
cell
origins
functions,
along
with
mechanisms
by
Tregs
influence
development.
In
addition,
we
highlight
therapeutic
strategies
targeting
Tregs-such
as
checkpoint
inhibitors
combinatorial
approaches-to
enhance
effector
responses.
A
deeper
understanding
Treg-mediated
immunosuppression
may
inform
design
more
effective
immunotherapies
precision
medicine
strategies.
Язык: Английский
Arnicolide D: a multi-targeted anticancer sesquiterpene lactone—preclinical efficacy and mechanistic insights
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
397(9), С. 6317 - 6336
Опубликована: Апрель 23, 2024
Язык: Английский
Zinc dampens antitumor immunity by promoting Foxp3+ regulatory T cells
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 23, 2024
Introduction
The
role
of
zinc
(Zn)
in
tumor
development
and
immune
modulation
has
always
been
paradoxical.
This
study
redefines
our
understanding
the
impact
Zn
on
cancer
progression
therapeutic
strategies.
Methods
We
investigated
effects
dietary
levels
responses.
included
examining
both
high
deficient
Zn,
as
well
chelation,
growth
cell
populations.
Specifically,
we
analyzed
frequency
Foxp3
+
regulatory
T-cells
(Tregs)
identified
FOXO1
Zn-mediated
Tregs.
Additionally,
explored
potential
clioquinol
(CQ)
enhancing
α
-PD-1
immunotherapy
responses,
particularly
melanoma.
Results
Our
findings
show
that
promotes
by
fostering
a
protumorigenic
environment
mediated
T
cells.
Increased
intake
was
found
to
facilitate
increasing
Treg
frequency.
In
contrast,
deficiency
chelation
tissue
emerged
potent
drivers
antitumor
immunity.
pinpointed
master
regulator
governing
influence
Discussion
These
results
reveal
novel
mechanistic
insight
into
how
influences
regulation.
identification
key
opens
new
avenues
for
biology.
Furthermore,
introduce
promising
approach
showing
administering
significantly
enhances
response,
revelations
transform
comprehension
multifaceted
tumorigenesis
regulation,
highlighting
innovative
possibilities
therapy.
Язык: Английский
Comprehensive single-cell transcriptomic profiling reveals molecular subtypes and prognostic biomarkers with implications for targeted therapy in esophageal squamous cell carcinoma
Translational Oncology,
Год журнала:
2024,
Номер
44, С. 101948 - 101948
Опубликована: Апрель 6, 2024
Esophageal
squamous
cell
carcinoma
(ESCC)
is
a
genetically
heterogeneous
disease
with
poor
clinical
outcomes.
Identification
of
biomarkers
linked
to
DNA
replication
stress
may
enable
improved
prognostic
risk
stratification
and
guide
therapeutic
decision
making.
We
performed
integrated
single-cell
RNA
sequencing
computational
analyses
define
the
molecular
determinants
subtypes
underlying
ESCC
heterogeneity.
Single-cell
was
on
samples
analyzed
using
Seurat.
Differential
gene
expression
analysis
used
identify
esophageal
phenotypes.
stress-related
genes
were
intersected
differential
data
potential
genes,
which
generate
(DRS)
score.
This
score
associated
evaluated
in
survival
analysis.
Putative
by
Cox
regression
consensus
clustering.
Mendelian
randomization
assessed
causal
role
PRKCB.
High
DRS
survival.
Four
(CDKN2A,
NUP155,
PPP2R2A,
PRKCB)
displayed
utility.
Three
identified
discrete
immune
properties.
A
12-gene
signature
robust
performance.
PRKCB
overexpressed
ESCC,
while
knockdown
reduced
migration.
provides
new
insights
into
heterogeneity
ESCC.
The
findings
that
patient
Experimental
validation
substantiates
utility
our
results.
Язык: Английский