Breast cancer: pathogenesis and treatments

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 18, 2025

Abstract Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes malignancy-related deaths in women. The increasingly nuanced molecular subtypes breast cancer have enhanced comprehension precision treatment this disease. mechanisms tumorigenesis progression been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, circadian rhythms. Technological advancements, particularly those integrated artificial intelligence, significantly improved accuracy detection diagnosis. emergence novel therapeutic concepts drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis models tailored individual patient risk expected are crucial, supporting era oncology for cancer. Despite rapid advancements increasing emphasis on clinical comprehensive update summary panoramic knowledge related disease needed. In review, we provide thorough overview global status including its epidemiology, factors, pathophysiology, subtyping. Additionally, elaborate latest research into contributing progression, emerging strategies, long-term management. This review offers valuable insights Cancer Research, thereby facilitating future progress both basic application.

Язык: Английский

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Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies

Nutrients, Год журнала: 2025, Номер 17(3), С. 529 - 529

Опубликована: Янв. 31, 2025

Fasting-feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal underscores importance maintaining alignment order to avoid creating metabolic environment conducive carcinogenesis following molecular systemic disruption performance immune function. chronicity such condition may support initiation progression cancer through variety mechanisms, including increased oxidative stress, suppression, activation proliferative signaling pathways. This review aims summarize current evidence from human studies provide an overview potential mechanisms underscoring role chrononutrition (including time-restricted eating) on risk. Current shows that morning chronotype, suggesting physiological rhythms eating timing, associated with lower risk cancer. Also, early prolonged nighttime fasting were also suggests chronotype influences cell cycle regulation, modulation pathways inflammation, gut microbiota fluctuations. In conclusion, although there are no clear guidelines this matter, emerging supports hypothesis time-related (i.e., time/calorie-restricted feeding intermittent/periodic fasting) could potentially lead reduced

Язык: Английский

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A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice

Scientific Data, Год журнала: 2025, Номер 12(1)

Опубликована: Фев. 3, 2025

The circadian clock regulates various physiological processes in mammals. core gene Bmal1 is crucial for maintaining the oscillations of system by controlling rhythmic expression numerous clock-controlled genes. To explore transcriptional changes associated with deletion liver tissues, we collected tissues from global and liver-specific knockout mice, along their respective control groups, at two time points (CT2 CT14) used them transcriptome sequencing analysis. Genotyping, locomotor activity analysis, comprehensive quality analyses, including base scores, GC content, mapping rates, confirmed high data. Differential analysis RT-qPCR validation reliability validity dataset. These data offer a valuable resource researchers investigating role BMAL1 physiology, pathology, broader field biology.

Язык: Английский

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Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care

International Journal of Dermatology, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

ABSTRACT The concept of aging has evolved from being primarily attributed to genetic factors recognizing the critical role epigenetic mechanisms. Recent advancements, such as clocks, have provided tools assess biological age and offer insights into processes at molecular level. In aesthetic dermatology, understanding these allows for more personalized, effective interventions targeting root causes skin aging. This review explores interplay changes, aging, potential personalized care enhance longevity rejuvenation. is based on an extensive literature search conducted across PubMed other scientific databases. Studies focused mechanisms DNA methylation, histone modifications, their relationship Particular attention was given recent advancements in including Horvath's Clock GrimAge, implications dermatological treatments. Epigenetic Clock, demonstrated utility assessing through methylation markers, revealing actionable processes. Energy‐based devices like fractional lasers radiofrequency shown promise reversing age‐related promoting collagen synthesis, reducing age. Additionally, lifestyle diet, sleep, circadian rhythm alignment significantly influence health. Integrating dermatology represents a paradigm shift rejuvenation, allowing treatments that address visible signs underlying Using clocks provides framework tailoring individual patient needs, optimizing outcomes, extending results. Future research should focus longitudinal studies, accessibility, ethical considerations fully harness epigenetics health overall well‐being.

Язык: Английский

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Circadian rhythms and breast cancer: unraveling the biological clock’s role in tumor microenvironment and ageing

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 30, 2024

Breast cancer (BC) is one of the most common and fatal malignancies among women worldwide. Circadian rhythms have emerged in recent studies as being involved pathogenesis breast cancer. In this paper, we reviewed molecular mechanisms by which dysregulation circadian genes impacts development BC, focusing on critical clock genes, brain muscle ARNT-like protein 1 (BMAL1) locomotor output cycles kaput (CLOCK). We discussed how rhythm disruption (CRD) changes tumor microenvironment (TME), immune responses, inflammation, angiogenesis. The CRD compromises surveillance features activities effectors, including CD8+ T cells tumor-associated macrophages, that are important an effective anti-tumor response. Meanwhile, review, discuss bidirectional interactions: age rhythms, aging further increases risk through reduced vasoactive intestinal polypeptide (VIP), affecting suprachiasmatic nucleus (SCN) synchronization, ability to repair damaged DNA, weakened immunity. These complex interplays open new avenues toward targeted therapies combination drugs with chronotherapy potentiate response while reducing progression for better outcomes. This review tries cover broad area emerging knowledge tumor-immune nexus affected

Язык: Английский

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Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response

Aging and Disease, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Circadian rhythm is a self-regulating 24-hour system that synchronizes with the day and night cycle in organisms. The regulation of this controlled by clock genes, which function to harmoniously express molecular levels facilitate orderly coordination various cellular processes, such as sleep, metabolism, endocrine function, cell proliferation immunity. root cause tumorigenesis body loses its normal growth at genetic level. Long-term disruptions circadian rhythms caused factors shift work, jet lag, unstable sleep patterns can impact health, leading health problems, including cancer. controls most functions related cancer progression, has significant on ability immune cells detect promote their clearance crucial implication for future tumor immunotherapy. This article aims review crosstalk between dysregulation tumorigenesis, response. Additionally, we discuss role disruption therapy, highlighting potential optimize treatment timing improve therapeutic outcomes.

Язык: Английский

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CRY1 fuels resistance to T cell-based immunotherapy in NANOGhigh cancers

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Cancer immunotherapies, including immune checkpoint blockade (ICB), have marked a significant breakthrough in cancer treatment but their clinical efficacy is limited immune-resistant tumors. Previously, we found that immunotherapy-mediated selection enriches tumors with both tumor-intrinsic and -extrinsic refractory phenotypes via the transcriptional induction of HDAC1 by NANOG. Here, identify CRY1 as critical target NANOG stabilizes Cyclin A MCL1 to promote stem cell-like property resistance cytotoxic T cell-mediated killing NANOG^high tumor cells through HDAC1-mediated epigenetic silencing APC3 TRIM17. Additionally, downregulates CXCL10 repression, thereby suppressing cell infiltration. Importantly, inhibition synergizes PD-1 adoptive transfer reducing growth converting into immune-sensitive Collectively, these findings highlight mediator NANOG/HDAC1 axis multiple properties suggest potential therapeutic target.

Язык: Английский

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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Фев. 4, 2025

Circadian rhythms are critical to coordinating body processes external environmental cues, such as light and feeding, ensure efficiency maintain optimal health. These controlled by ‘clock’ transcription factors, Clock, Bmal1, Per1/2, Cry1/2, Rev-erbs, which present in almost every tissue. In modern society, disruptions normal circadian increasingly prevalent due extended lighting, shift work, long-distance travel. misalign cues contribute diseases obesity non-alcoholic fatty liver disease. They also exacerbate pre-existing health issues, depression inflammatory bowel The response acute infection displays remarkable rhythmicity humans with increased activity during the night or rest period. Severe bloodborne infections, exemplified sepsis progression septic shock, can not only disrupt of but be exacerbated misalignment. Examples shock include alteration loss hormonal controlling blood pressure inflammation, white cell counts, cytokine secretions. changes hinder recovery increase mortality. Chronotherapy chronopharmacotherapy promising approaches resynchronise leverage optimise medication efficacy, respectively, hold much potential treatment shock. Despite knowledge how change these grave conditions, very little research has been undertaken on use therapies support management. This review details associated influence they have morbidity mortality, clinical benefits circadian-modulating therapies.

Язык: Английский

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Bmal1 Deficiency in Neutrophils Alleviates Symptoms Induced by High-Fat Diet

iScience, Год журнала: 2025, Номер 28(3), С. 112038 - 112038

Опубликована: Фев. 25, 2025

Язык: Английский

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The Influence of Occupational Factors on Contact Dermatitis in Symptomatic Healthcare Workers: A Patch Test Study

Diseases, Год журнала: 2025, Номер 13(3), С. 77 - 77

Опубликована: Март 7, 2025

Healthcare workers (HCWs) are frequently exposed to a variety of chemical agents, which can result in the development allergic or irritant contact dermatitis. The present study aimed assess prevalence skin sensitization among HCWs who presented with symptoms dermatitis, considering both occupational and non-occupational risk factors. population comprised 127 attended routine health surveillance at Tor Vergata Teaching Hospital Rome between November 2023 May 2024. A structured dermatitis questionnaire patch testing were administered participants. Demographic lifestyle data, including information on occupation, night shift work, smoking habits, body mass index (BMI), collected. Patch test positivity was observed 31.5% participants, most common clinical presentation being erythematous-desquamative significantly higher likelihood nurses (57.1%), particularly for nickel sensitization, compared other groups. trend towards an association work observed, although this did not reach statistical significance. No significant associations found ages over 35 years, sex, BMI. These findings highlight elevated nurses, emphasizing need targeted interventions, exposure reduction strategies protective measures, mitigate hazards healthcare settings.

Язык: Английский

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