2‐Undecanone induces ferroptosis via the STAT3/GPX4 pathway to enhance sensitivity of renal cell carcinoma to sunitinib
BioFactors,
Год журнала:
2025,
Номер
51(2)
Опубликована: Март 1, 2025
Abstract
The
development
of
resistance
significantly
reduces
the
efficacy
targeted
therapies,
such
as
sunitinib,
in
renal
cell
carcinoma
(RCC)
patients,
emphasizing
need
for
novel
therapeutic
agents.
Natural
products,
known
their
diverse
chemical
structures
and
mechanisms
action,
offer
promising
anti‐tumor
potential
with
favorable
safety
profiles
lower
toxicity
compared
to
synthetic
drugs.
2‐Undecanone,
a
natural
compound
extracted
from
Houttuynia
cordata
Thunb.,
has
demonstrated
effects,
but
its
specific
role
RCC
treatment
remains
unclear.
In
this
study,
we
integrated
network
pharmacology
vitro
experiments
explore
underlying
2‐Undecanone's
effects
on
RCC.
Our
results
reveal
that
2‐Undecanone
effectively
inhibits
viability,
proliferation,
migration.
Mechanistically,
discovered
induces
ferroptosis
cells
by
promoting
reactive
oxygen
species
(ROS)
generation,
intracellular
Fe
2+
accumulation,
glutathione
(GSH)
production,
lipid
peroxidation,
modulation
STAT3/GPX4
signaling
pathway.
Furthermore,
lowers
IC50
value
sunitinib
cells,
enhancing
sensitivity
therapy.
Additionally,
potentiates
sunitinib‐induced
ferroptosis.
summary,
our
research
reveals
enhances
through
targeting
pathway,
providing
new
insights
into
strategies
Язык: Английский
Global research status and frontiers on ferroptosis in hepatocellular carcinoma: a comprehensive bibliometric and visualized analysis
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 2, 2025
Objective
The
purpose
of
this
study
was
to
analyze
the
research
hotspots
and
future
trends
in
field
ferroptosis
hepatocellular
carcinoma
past
10
years
by
using
bibliometrics
visualization
software,
provide
reference
for
directions
field.
Methods
Web
Science
database
searched
from
January
1,
2012,
October
30,
2024,
annual
publication
volume,
countries,
institutions,
journals,
authors,
references,
keywords,
other
information
were
analyzed
bibliometrics,
VOSviewer,
CiteSpace.
Results
A
total
645
English
articles
729
institutions
32
countries
included
study,
with
4545
authors
published
261
journals.
In
three
years,
518
published,
accounting
80.3%.
China
has
most
publications,
followed
United
States.
Frontiers
Oncology
had
highest
number
papers
(n=26),
while
Cell
citations
(n=1206).
current
mainly
focuses
on
two
aspects:
one
is
mechanism
explore
new
therapeutic
targets,
exploration
methods,
such
as
photodynamic
therapy
nanomaterials,
order
inhibit
proliferation
tumor
cells,
reduce
drug
resistance,
enhance
efficacy
regulating
ferroptosis,
which
may
become
a
development
trend.
Conclusion
recent
there
have
been
increasing
studies
association
between
carcinoma.
This
first
comprehensive
bibliometric
provides
reliable
promotes
its
further
development.
Язык: Английский
The Role of Pyroptosis in the Progression and Targeted Therapeutic Approaches for Urological Malignancies
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 9567 - 9581
Опубликована: Ноя. 1, 2024
The
prevalence
of
urological
malignancies
continues
to
pose
a
significant
global
health
challenge,
particularly
due
the
poor
prognosis
associated
with
advanced
stages
these
diseases.
Consequently,
there
is
an
urgent
need
deepen
our
understanding
molecular
mechanisms
governing
development
facilitate
breakthroughs
in
diagnosis
and
treatment.
Pyroptosis,
novel
specific
form
programmed
cell
death,
plays
crucial
role
regulating
inflammatory
responses,
development,
tissue
homeostasis,
stress
responses.
Recent
research
has
revealed
close
association
between
pyroptosis
malignancies.
In
this
paper,
we
review
pathogenesis
recent
advancements
malignancies,
elucidate
involved
its
regulation,
aim
provide
new
directions
for
clinical
management
Язык: Английский