Potential role of lactylation in intrinsic immune pathways in lung cancer DOI Creative Commons

Mengdie Huang,

Ye Jin, Dandan Zhao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 17, 2025

Lung cancer, one of the most lethal malignancies, has seen its therapeutic strategies become a focal point significant scientific attention. Intrinsic immune signaling pathways play crucial roles in anti-tumor immunity but face clinical application challenges despite promising preclinical outcomes. Lactylation, an emerging research focus, may influences lung cancer progression by modulating functions histones and non-histone proteins. Recent findings have suggested that lactylation regulates key intrinsic molecules, including cGAS-STING, TLR, RIG-I, thereby impacting interferon expression. However, precise mechanisms which governs remain unclear. This review presents comprehensive systematic analysis relationship between emphasizes innovative perspective linking lactylation-mediated epigenetic modifications with regulation. By thoroughly examining current findings, this uncovers potential regulatory highlights implications targeting cancer. Future investigations into intricate interactions are anticipated to unveil novel targets strategies, potentially improving patient survival

Язык: Английский

Potential role of lactylation in intrinsic immune pathways in lung cancer DOI Creative Commons

Mengdie Huang,

Ye Jin, Dandan Zhao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 17, 2025

Lung cancer, one of the most lethal malignancies, has seen its therapeutic strategies become a focal point significant scientific attention. Intrinsic immune signaling pathways play crucial roles in anti-tumor immunity but face clinical application challenges despite promising preclinical outcomes. Lactylation, an emerging research focus, may influences lung cancer progression by modulating functions histones and non-histone proteins. Recent findings have suggested that lactylation regulates key intrinsic molecules, including cGAS-STING, TLR, RIG-I, thereby impacting interferon expression. However, precise mechanisms which governs remain unclear. This review presents comprehensive systematic analysis relationship between emphasizes innovative perspective linking lactylation-mediated epigenetic modifications with regulation. By thoroughly examining current findings, this uncovers potential regulatory highlights implications targeting cancer. Future investigations into intricate interactions are anticipated to unveil novel targets strategies, potentially improving patient survival

Язык: Английский

Процитировано

0