Heart failure in diabetes

Metabolism, Год журнала: 2021, Номер 125, С. 154910 - 154910

Опубликована: Окт. 8, 2021

Язык: Английский

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The Role of Inflammation in CKD

Cells, Год журнала: 2023, Номер 12(12), С. 1581 - 1581

Опубликована: Июнь 7, 2023

Chronic kidney disease (CKD) affects many adults worldwide. Persistent low-grade inflammation is a substantial factor in its development and progression has correlated with increased mortality cardiovascular problems. This product of dysregulation the normal balance between pro- anti-inflammatory markers. Various factors such as innate immune system activation, reactive oxygen species production, periodontal disease, systems intestinal dysbiosis result this balance. Furthermore, down-effects hypertension, renal fibrosis acceleration function decline. Moreover, over time been linked to malignancy CKD. As CKD progresses, patients require dialysis, which negative bidirectional relationship persistent inflammation. Treatment options for are vast, including cytokine inhibitors, statins diets. However, more research needed create standardized management plan. In review, we will examine physiology system. We then delve into pathology behind inflammation, various causes downstream effects dialysis potential treatments

Язык: Английский

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Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice

Antioxidants, Год журнала: 2021, Номер 10(3), С. 390 - 390

Опубликована: Март 5, 2021

Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic caused by an uncommon drug adverse reaction that can develop to conditions spanning from asymptomatic laboratory abnormalities acute failure (ALF) and death. The cellular molecular mechanisms involved in DILI are poorly understood. Hepatocyte damage be the metabolic activation chemically active intermediate metabolites covalently bind macromolecules (e.g., proteins, DNA), forming protein adducts—neoantigens—that lead generation oxidative stress, mitochondrial dysfunction, endoplasmic reticulum (ER) which eventually cell In parallel, damage-associated patterns (DAMPs) stimulate immune response, whereby inflammasomes play pivotal role, neoantigen presentation on specific human leukocyte antigen (HLA) molecules trigger adaptive response. A wide array antioxidant exists counterbalance effect oxidants, including glutathione (GSH), superoxide dismutase (SOD), catalase, peroxidase (GPX), detoxification. These get compromised during DILI, triggering imbalance between oxidants antioxidants defense systems, generating stress. As result exacerbated several danger signals, damage, death, inflammatory markers, microRNAs (miRNAs) related extracellular vesicles (EVs) have already been reported as mechanistic biomarkers. Here, status quo future directions thoroughly discussed, with special focus role stress development new

Язык: Английский

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Loop Between NLRP3 Inflammasome and Reactive Oxygen Species

Antioxidants and Redox Signaling, Год журнала: 2021, Номер 36(10-12), С. 784 - 796

Опубликована: Сен. 20, 2021

Significance: Inflammasomes are cytosolic multiprotein complexes that mediate innate immune pathways. activate inflammatory caspases and regulate cytokines interleukin (IL)-1β IL-18 as well cell death (pyroptosis). Among known inflammasomes, NLRP3 (NLR family pyrin domain containing 3) inflammasome is unique studied owing to the fact it senses a broad range of stimuli implicated in pathogenesis both microbial sterile diseases. Recent Advances: Reactive oxygen species (ROS), especially derived from mitochondria, one critical mediators activation. Furthermore, inflammasome-driven inflammation recruits cells, including macrophages neutrophils, which turn cause ROS production, suggesting feedback loop between inflammasome. Critical Issues: The precise mechanism how affects activation still need be addressed. This review will summarize current knowledge on molecular mechanisms underlying with particular emphasis intricate balance Future Directions: Understanding this relationship rather than traditionally understood linear enable fine-tune under varied pathological settings. Antioxid. Redox Signal. 36, 784-796.

Язык: Английский

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Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics

The International Journal of Biochemistry & Cell Biology, Год журнала: 2021, Номер 136, С. 106013 - 106013

Опубликована: Май 19, 2021

Язык: Английский

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Antioxidant, Anti-Inflammatory and Cytotoxic Activity of Phenolic Compound Family Extracted from Raspberries (Rubus idaeus): A General Review

Antioxidants, Год журнала: 2022, Номер 11(6), С. 1192 - 1192

Опубликована: Июнь 17, 2022

Raspberries (Rubus idaeus) possess a wide phenolic family profile; this serves the role of self-protection for plant. Interest in these compounds have significantly increased, since they been classified as nutraceuticals due to positive health effects provided consumers. Extensive chemical, vitro and vivo studies performed prove validate benefits their possible applications an aid when treating several chronic degenerative diseases, characterized by oxidative stress inflammatory response. While many diseases could be co-adjuvanted intake compounds, review will mainly discuss on cancer. Anthocyanins ellagitannins are known provide major antioxidant capacity raspberries. The aim is summarize current knowledge concerning compound raspberries, topics discussed include characterization, biosynthesis, bioavailability, cytotoxicity, anti-inflammatory activities.

Язык: Английский

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Pro-Inflammatory and Anti-Inflammatory Interleukins in Infectious Diseases: A Comprehensive Review

Tropical Medicine and Infectious Disease, Год журнала: 2024, Номер 9(1), С. 13 - 13

Опубликована: Янв. 4, 2024

Interleukins (ILs) are signaling molecules that crucial in regulating immune responses during infectious diseases. Pro-inflammatory ILs contribute to the activation and recruitment of cells, whereas anti-inflammatory help suppress excessive inflammation promote tissue repair. Here, we provide a comprehensive overview role pro-inflammatory diseases, with focus on mechanisms underlying their effects, diagnostic therapeutic potential, emerging trends IL-based therapies.

Язык: Английский

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Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis

International Immunopharmacology, Год журнала: 2022, Номер 109, С. 108782 - 108782

Опубликована: Апрель 23, 2022

Язык: Английский

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Sex differences in markers of oxidation and inflammation. Implications for ageing

Mechanisms of Ageing and Development, Год журнала: 2023, Номер 211, С. 111797 - 111797

Опубликована: Март 1, 2023

Sexual dimorphism is a key factor to consider in the ageing process given impact that it has on life expectancy. The oxidative-inflammatory theory of states result establishment oxidative stress which, due interplay immune system, translates into inflammatory stress, and both processes are responsible for damage loss function an organism. We show there relevant gender differences number markers propose they may account differential lifespan between sexes, males display, general, higher oxidation basal inflammation. In addition, we explain significant role circulating cell-free DNA as marker inductor inflammation, connecting having potential become useful marker. Finally, discuss how changes take place differentially with each sex, which could also have sex-differential lifespan. Further research including sex essential variable needed understand grounds better comprehend itself.

Язык: Английский

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Mechanistic insights from inflammasome structures

Nature reviews. Immunology, Год журнала: 2024, Номер 24(7), С. 518 - 535

Опубликована: Фев. 19, 2024

Язык: Английский

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