Critical Reviews in Food Science and Nutrition,
Год журнала:
2020,
Номер
62(13), С. 3509 - 3534
Опубликована: Дек. 30, 2020
Aging
is
characterized
by
the
functional
decline
of
tissues
and
organs
increased
risk
aging-associated
disorders,
which
pose
major
societal
challenges
are
a
public
health
priority.
Despite
extensive
human
genetics
studies,
limited
progress
has
been
made
linking
with
aging.
There
growing
realization
that
altered
assembly,
structure
dynamics
gut
microbiota
actively
participate
in
aging
process.
Age-related
microbial
dysbiosis
involved
reshaping
immune
responses
during
aging,
manifest
as
immunosenescence
(insufficiency)
inflammaging
(over-reaction)
accompany
many
age-associated
enteric
extraenteric
diseases.
The
can
be
regulated,
suggesting
potential
target
for
interventions.
This
review
summarizes
recent
findings
on
physiological
succession
across
life-cycle,
roles
mechanisms
healthy
alterations
diseases,
microbiota-targeted
anti-aging
strategies.
Journal of Advanced Research,
Год журнала:
2021,
Номер
38, С. 223 - 244
Опубликована: Сен. 17, 2021
Recent
research
on
the
implications
of
gut
microbiota
brain
functions
has
helped
to
gather
important
information
relationship
between
them.
Pathogenesis
neurological
disorders
is
found
be
associated
with
dysregulation
gut-brain
axis.
Some
bacteria
metabolites
are
directly
increase
in
reactive
oxygen
species
levels,
one
most
risk
factors
neurodegeneration.
Besides
their
morbid
association,
also
play
a
significant
role
reducing
onset
these
life-threatening
disorders.Studies
done
recent
past
raises
two
link
and
brain:
"gut
microbiota-oxidative
stress-neurodegeneration"
microbiota-antioxidant-neuroprotection.
This
review
aims
gives
deep
insight
our
readers,
collective
studies
done,
focusing
mediated
oxidative
stress
involved
neurodegeneration
along
focus
those
showing
involvement
neuroprotection.This
focused
three
main
key
concepts.
Firstly,
mounting
evidences
from
clinical
preclinical
arenas
shows
influence
resulting
dysfunctional
processes.
Therefore,
we
describe
potential
influencing
vulnerability
stress,
budding
causative
Alzheimer's
Parkinson's
disease.
Secondly,
contributing
roles
been
observed
attenuating
inflammation
via
its
own
or
by
producing
secondary
and,
modulation
population
antioxidative
anti-inflammatory
probiotics
have
shown
promising
neuro
resilience.
Thirdly,
high
throughput
silico
tools
databases
correlation
microbiome,
health,
thus
providing
fascinating
perspective
new
avenues
for
therapeutic
options.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2020,
Номер
62(13), С. 3509 - 3534
Опубликована: Дек. 30, 2020
Aging
is
characterized
by
the
functional
decline
of
tissues
and
organs
increased
risk
aging-associated
disorders,
which
pose
major
societal
challenges
are
a
public
health
priority.
Despite
extensive
human
genetics
studies,
limited
progress
has
been
made
linking
with
aging.
There
growing
realization
that
altered
assembly,
structure
dynamics
gut
microbiota
actively
participate
in
aging
process.
Age-related
microbial
dysbiosis
involved
reshaping
immune
responses
during
aging,
manifest
as
immunosenescence
(insufficiency)
inflammaging
(over-reaction)
accompany
many
age-associated
enteric
extraenteric
diseases.
The
can
be
regulated,
suggesting
potential
target
for
interventions.
This
review
summarizes
recent
findings
on
physiological
succession
across
life-cycle,
roles
mechanisms
healthy
alterations
diseases,
microbiota-targeted
anti-aging
strategies.
