Updates in Alzheimer's disease: from basic research to diagnosis and therapies

Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)

Опубликована: Сен. 4, 2024

Язык: Английский

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Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies

Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)

Опубликована: Авг. 6, 2024

Abstract The deposition of abnormal tau protein is characteristic Alzheimer’s disease (AD) and a class neurodegenerative diseases called tauopathies. Physiologically, maintains an intrinsically disordered structure plays diverse roles in neurons. Pathologically, undergoes post-translational modifications forms oligomers or fibrous aggregates In this review, we briefly introduce several tauopathies discuss the mechanisms mediating aggregation propagation. We also describe toxicity pathology. Finally, explore early diagnostic biomarkers treatments targeting tau. Although some encouraging results have been achieved animal experiments preclinical studies, there still no cure for More in-depth basic clinical research on pathogenesis necessary.

Язык: Английский

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New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies

Trends in Immunology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Modeling forebrain regional development and connectivity by human brain organoids

Current Opinion in Genetics & Development, Год журнала: 2025, Номер 91, С. 102324 - 102324

Опубликована: Фев. 20, 2025

Язык: Английский

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Genetic admixture predictors of fetal alcohol spectrum disorders (FASD) in a South African population

Gene, Год журнала: 2024, Номер 931, С. 148854 - 148854

Опубликована: Авг. 13, 2024

Язык: Английский

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Highly sensitive β-amyloid1-42 oligomer aptamer-based assay via dual cyclic amplifications of three-way catalytic hairpin assembly and palindrome polymerase reaction

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 423, С. 136750 - 136750

Опубликована: Окт. 9, 2024

Язык: Английский

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Preclinical research (on rare diseases): we need to talk about health equity

Mammalian Genome, Год журнала: 2024, Номер unknown

Опубликована: Окт. 26, 2024

There is a thriving, worldwide, biomedical research community working to understand the molecular bases of diseases all types, continuously driving improved diagnostics and therapies. Developments in genetics experimental medicine are yielding novel genetic therapies that were hardly dreamt 40 years ago. But along with these scientific achievements, there exist challenges ensuring 21st century medical interventions accessible who need them. This perspective will discuss how preclinical research, focus on rare diseases, can better contribute healthcare ecosystems oriented towards greater health equity. contribution may require changes prevailing culture support from relevant institutions wider community.

Язык: Английский

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Targeting Tau in Alzheimer’s and Beyond: Insights into Pathology and Therapeutic Strategies

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102639 - 102639

Опубликована: Дек. 1, 2024

Язык: Английский

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