Immunometabolism,
Год журнала:
2025,
Номер
7(2), С. e00059 - e00059
Опубликована: Март 19, 2025
In
the
last
couple
of
decades,
cancer
research
has
been
shifting
its
focus
to
immune
system.
Cancer
cells,
with
their
ability
adapt
and
evade
responses,
seem
accelerate
evolutionary
pressure
that
put
on
our
system
during
evolution.
We
thus
try
aid
these
natural
selection
processes
assist
combat
cancer.
Here,
we
are
discussing
a
study
by
Greg
Delgoffe
colleagues
was
published
in
Nature
Immunology
December
2024,
exploring
new
approach
bring
dysfunctional
cells
back
life
blocking
lactate
uptake.
Cells,
Год журнала:
2025,
Номер
14(4), С. 283 - 283
Опубликована: Фев. 14, 2025
The
immune
system
must
carefully
balance
fighting
pathogens
with
minimization
of
inflammation
and
avoidance
autoimmune
responses.
Over
the
past
ten
years,
researchers
have
extensively
studied
mechanisms
regulating
this
delicate
balance.
Comprehending
these
is
essential
for
developing
treatments
inflammatory
conditions.
This
review
aims
to
synthesize
knowledge
immunoregulatory
processes
published
from
2014-2024
highlight
discoveries
that
provide
fresh
perspectives
on
complex
keywords
"molecular
mechanisms",
"immune
regulation",
signaling
pathways",
homeostasis"
were
used
search
PubMed
articles
between
2014
2024,
a
preference
in
three
years.
Recent
research
has
pinpointed
impact
factors
such
as
cytokine
signaling,
T-cell
regulation,
epigenetic
immunometabolism
function.
New
highlights
intricate
interactions
other
molecular
elements.
A
key
area
interest
non-coding
RNAs
metabolic
pathways
regulation
Exploring
by
which
regulated
will
new
avenues
address
International Journal of Clinical and Experimental Pathology,
Год журнала:
2025,
Номер
18(2), С. 63 - 76
Опубликована: Янв. 1, 2025
Ischemic
Stroke
(IS)
is
characterized
by
complex
molecular
alterations
involving
disruptions
in
lipid
metabolism
and
immune
interactions.
However,
the
roles
of
metabolism-associated
genes
pathogenesis
IS
through
regulation
interaction
are
rarely
explored.
In
this
study,
we
aimed
to
explore
intricate
correlation
between
changes
a
machine-learning
algorithm.
We
downloaded
GSE16561,
GSE22255,
GSE37587
datasets
from
NCBI.
Using
GSE16561
dataset,
analyzed
differential
gene
expression
profiles
related
with
"Limma"
R
package.
constructed
diagnostic
model
employing
techniques
such
as
Least
Absolute
Shrinkage
Selection
Operator
(LASSO)
Cox
regression
Random
Forest
(RF),
which
was
further
validated
using
independent
GSE22255
datasets.
Correlations
cell
percentages
were
examined
Spearman
analysis.
value
these
28
clinical
samples
RT-qPCR.
identified
26
significant
disparities
normal
diseased
groups,
closely
linked
populations.
Seven
signature
(ACSS1,
ADSL,
CYP27A1,
MTF1,
SOAT1,
STAT3,
SUMF2)
LASSO
RF
algorithms
for
potential
model,
effectively
distinguishing
healthy
both
training
validation
(AUC
=
0.725)
The
mRNA
levels
blood
biomarker
patients
our
samples.
Single-cell
analysis
revealed
high
Cyp27a1
dendritic
cells
macrophages,
decreasing
Soat
progenitor
disease
progressed.
Stat3
most
upregulated
Additionally,
regulatory
network
transcription
factors
regulating
STAT3.
This
study
novel
biomarkers
IS,
enhancing
understanding
shedding
light
on
may
facilitate
innovative
approaches
IS.
Immunometabolism,
Год журнала:
2025,
Номер
7(2), С. e00059 - e00059
Опубликована: Март 19, 2025
In
the
last
couple
of
decades,
cancer
research
has
been
shifting
its
focus
to
immune
system.
Cancer
cells,
with
their
ability
adapt
and
evade
responses,
seem
accelerate
evolutionary
pressure
that
put
on
our
system
during
evolution.
We
thus
try
aid
these
natural
selection
processes
assist
combat
cancer.
Here,
we
are
discussing
a
study
by
Greg
Delgoffe
colleagues
was
published
in
Nature
Immunology
December
2024,
exploring
new
approach
bring
dysfunctional
cells
back
life
blocking
lactate
uptake.
