FEMS Microbiology Ecology,
Год журнала:
2022,
Номер
98(9)
Опубликована: Июль 13, 2022
Abstract
Insects
are
associated
with
a
plethora
of
different
microbes
which
we
only
starting
to
understand
their
role
in
shaping
insect–plant
interactions.
Besides
directly
benefitting
from
symbiotic
microbial
metabolism,
insects
obtain
and
transmit
within
environment,
making
them
ideal
vectors
potential
beneficiaries
plant
diseases
that
alter
defenses.
To
prevent
damage,
plants
elicit
stress-specific
defenses
ward
off
microbiota.
However,
both
harbor
wealth
adaptations
allow
circumvent
effective
defense
activation.
In
the
past
decades,
it
has
become
apparent
enormous
diversity
metabolic
insect-associated
may
play
far
more
important
interactions
than
previously
anticipated.
The
latter
have
implications
for
development
sustainable
pest
control
strategies.
Therefore,
this
review
sheds
light
on
current
knowledge
multitrophic
insect–microbe–plant
rapidly
expanding
field
research.
Frontiers in Microbiology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 29, 2022
Natural
products
derived
from
microorganisms
serve
as
a
vital
resource
of
valuable
pharmaceuticals
and
therapeutic
agents.
Streptomyces
is
the
most
ubiquitous
bacterial
genus
in
environments
with
prolific
capability
to
produce
diverse
natural
significant
biological
activities
medicine,
environments,
food
industries,
agronomy
sectors.
However,
many
remain
unexplored
among
.
It
exigent
develop
novel
antibiotics,
agrochemicals,
anticancer
medicines,
etc.,
due
fast
growth
resistance
cancer
chemotherapeutics,
pesticides.
This
review
article
focused
secreted
by
their
function
importance
curing
diseases
agriculture.
Moreover,
it
discussed
genomic-driven
drug
discovery
strategies
also
gave
future
perspective
for
development
Journal of Medical Microbiology,
Год журнала:
2020,
Номер
69(8), С. 1040 - 1048
Опубликована: Июль 21, 2020
Given
the
increased
reporting
of
multi-resistant
bacteria
and
shortage
newly
approved
medicines,
researchers
have
been
looking
towards
extreme
unusual
environments
as
a
new
source
antibiotics.
Processes,
Год журнала:
2020,
Номер
8(4), С. 470 - 470
Опубликована: Апрель 16, 2020
Over
a
long
period
of
time,
humans
have
explored
many
natural
resources
looking
for
remedies
various
ailments.
Traditional
medicines
played
an
intrinsic
role
in
human
life
thousands
years,
with
people
depending
on
medicinal
plants
and
their
products
as
dietary
supplements
well
using
them
therapeutically
treatment
chronic
disorders,
such
cancer,
malaria,
diabetes,
arthritis,
inflammation,
liver
cardiac
disorders.
However,
plant
are
not
sufficient
recently
emerging
diseases.
In
addition,
the
seasonal
availability
other
political
factors
put
constrains
some
rare
species.
The
actual
breakthrough
drug
discovery
came
concurrently
penicillin
from
Penicillium
notatum
1929.
This
dramatically
changed
research
positioned
microbial
one
most
important
clues
due
to
availability,
variability,
great
biodiversity,
unique
structures,
bioactivities
produced.
number
commercially
available
active
compounds
sources
date
exceeds
those
discovered
sources.
this
review,
we
introduce
short
history
certain
features
recent
approaches,
specifying
origin,
featured
molecules,
diversity
producing
Moreover,
discuss
new
approaches
trends
field.
Animals
in
the
wild
are
able
to
subsist
on
pathogen-infected
and
poisonous
food
show
immunity
various
diseases.
These
may
be
due
their
microbiota,
yet
we
have
a
poor
understanding
of
animal
microbial
diversity
function.
We
used
metagenomics
analyze
gut
microbiota
more
than
180
species
wild,
covering
diverse
classes,
feeding
behaviors,
geographies,
traits.
Using
de
novo
metagenome
assembly,
constructed
functionally
annotated
database
5000
genomes,
comprising
1209
bacterial
which
75%
unknown.
The
composition,
diversity,
functional
content
exhibit
associations
with
taxonomy,
diet,
activity,
social
structure,
life
span.
identify
animals
as
largely
untapped
resource
for
discovery
therapeutics
biotechnology
applications.
Science,
Год журнала:
2020,
Номер
370(6519), С. 974 - 978
Опубликована: Ноя. 20, 2020
New
antifungal
drugs
are
urgently
needed
to
address
the
emergence
and
transcontinental
spread
of
fungal
infectious
diseases,
such
as
pandrug-resistant
Candida
auris.
Leveraging
microbiomes
marine
animals
cutting-edge
metabolomics
genomic
tools,
we
identified
encouraging
lead
molecules
with
in
vivo
efficacy.
The
most
promising
lead,
turbinmicin,
displays
potent
vitro
mouse-model
efficacy
toward
multiple-drug-resistant
pathogens,
exhibits
a
wide
safety
index,
functions
through
fungal-specific
mode
action,
targeting
Sec14
vesicular
trafficking
pathway.
efficacy,
safety,
action
distinct
from
other
make
turbinmicin
highly
drug
help
devastating
global
pathogens
C.
Natural Product Reports,
Год журнала:
2021,
Номер
38(11), С. 1994 - 2023
Опубликована: Янв. 1, 2021
Covering:
up
to
2021Metagenomics
has
yielded
massive
amounts
of
sequencing
data
offering
a
glimpse
into
the
biosynthetic
potential
uncultivated
microbial
majority.
While
genome-resolved
information
about
communities
from
nearly
every
environment
on
earth
is
now
available,
ability
accurately
predict
biocatalytic
functions
directly
remains
challenging.
Compared
primary
metabolic
pathways,
enzymes
involved
in
secondary
metabolism
often
catalyze
specialized
reactions
with
diverse
substrates,
making
these
pathways
rich
resources
for
discovery
new
enzymology.
To
date,
functional
insights
gained
studies
environmental
DNA
(eDNA)
have
largely
relied
PCR-
or
activity-based
screening
eDNA
fragments
cloned
fosmid
cosmid
libraries.
As
an
alternative,
shotgun
metagenomics
holds
underexplored
by
avoiding
common
biases
introduced
through
activity-guided
workflows.
However,
inferring
enzyme
similar
searching
'needle
haystack'
without
direct
links
between
genotype
and
phenotype.
The
goal
this
review
provide
roadmap
navigate
metagenomic
identify
candidate
enzymes.
We
cover
both
computational
experimental
strategies
mine
metagenomes
explore
protein
sequence
space
spotlight
natural
product
biosynthesis.
Specifically,
we
compare
Microbiology Research,
Год журнала:
2022,
Номер
13(3), С. 418 - 465
Опубликована: Июль 1, 2022
There
is
a
real
consensus
that
new
antibiotics
are
urgently
needed
and
the
best
chance
for
combating
antibiotic
resistance.
The
phylum
Actinobacteria
one
of
main
producers
antibiotics,
with
recent
paradigm
shift
whereby
rare
actinomycetes
have
been
increasingly
targeted
as
source
secondary
metabolites
discovery
antibiotics.
However,
this
review
shows
genus
Streptomyces
still
largest
current
producer
innovative
metabolites.
Between
January
2015
December
2020,
significantly
high
number
novel
spp.
isolated
from
different
environments,
including
extreme
symbionts,
terrestrial
soils,
sediments
also
marine
mainly
invertebrates
sediments.
This
highlights
135
species
during
6-year
period
108
environment
27
sources.
A
brief
summary
pre-treatment
methods
used
successful
isolation
some
discussed,
well
biological
activities
total
279
recorded
121
which
exhibit
diverse
activity.
greatest
originated
terrestrial-sourced
