Advances and opportunities in the exciting world of azobenzenes

Nature Reviews Chemistry, Год журнала: 2021, Номер 6(1), С. 51 - 69

Опубликована: Ноя. 18, 2021

Язык: Английский

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Molecular photoswitches in aqueous environments

Chemical Society Reviews, Год журнала: 2021, Номер 50(22), С. 12377 - 12449

Опубликована: Янв. 1, 2021

Molecular photoswitches are inherently lipophilic and do not spontaneously dissolve in water. We describe the effect of water on photochemical properties strategies to solubilize organic apply them aqueous media.

Язык: Английский

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Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Сен. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Язык: Английский

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Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs

ACS Central Science, Год журнала: 2019, Номер 5(10), С. 1682 - 1690

Опубликована: Сен. 17, 2019

Off-tissue effects are persistent issues of modern inhibition-based therapies. By merging the strategies photopharmacology and small-molecule degraders, we introduce a novel concept for spatiotemporal control induced protein degradation that potentially prevents off-tissue toxicity. Building on successful principle bifunctional all-small-molecule Proteolysis Targeting Chimeras (PROTACs), designed photoswitchable PROTACs (

Язык: Английский

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Advances in Application of Azobenzene as a Trigger in Biomedicine: Molecular Design and Spontaneous Assembly

Advanced Materials, Год журнала: 2021, Номер 33(26)

Опубликована: Май 24, 2021

Abstract Azobenzene is a well‐known derivative of stimulus‐responsive molecular switches and has shown superior performance as functional material in biomedical applications. The results multiple studies have led to the development light/hypoxia‐responsive azobenzene for use. In recent years, long‐wavelength‐responsive been developed. Matching longer wavelength absorption hypoxia‐response characteristics switch unit bio‐optical window large effective stimulus response. addition, used hypoxia‐sensitive connector via biological cleavage under appropriate conditions. This resulted on/off state switching properties such pharmacology fluorescence activity. Herein, advances design fabrication trigger biomedicine are summarized.

Язык: Английский

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Optical control of neuronal ion channels and receptors

Nature reviews. Neuroscience, Год журнала: 2019, Номер 20(9), С. 514 - 532

Опубликована: Июль 9, 2019

Язык: Английский

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Computational Design and Synthesis of a Deeply Red-Shifted and Bistable Azobenzene

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(14), С. 6538 - 6547

Опубликована: Март 24, 2020

We computationally dissected the electronic and geometrical influences of ortho-chlorinated azobenzenes on their photophysical properties. X-ray analysis provided insight that trans-tetra-ortho-chloro azobenzene is conformationally flexible thus subject to molecular motions. This allows photoswitch adopt a range red-shifted geometries, which account for extended n → π* band tails. On basis our results, we designed di-ortho-fluoro di-ortho-chloro (dfdc) computational evidence superiority this substitution pattern tetra-ortho-chloro azobenzene. Thereafter, synthesized dfdc by ortho-chlorination via 2-fold C–H activation experimentally confirmed its structural properties through UV–vis, NMR, analyses. The advantages include near-bistable isomers an increased separation bands between trans- cis-conformations, generation unusually high levels cis-isomer irradiation with green/yellow light as well red within biooptical window.

Язык: Английский

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Strategies for designing proteolysis targeting chimaeras (PROTACs)

Medicinal Research Reviews, Год журнала: 2022, Номер 42(3), С. 1280 - 1342

Опубликована: Янв. 10, 2022

Abstract Proteolysis targeting chimaeras (PROTACs) is a cutting edge and rapidly growing technique for new drug discovery development. Currently, the largest challenge in molecular design development of PROTACs efficient identification potent drug‐like degraders. This review aims to comprehensively summarize analyse state‐of‐the‐art methods strategies PROTACs. We provide detailed illustration general principles tactics designing PROTACs, highlight representative case studies, discuss advantages limitations these strategies. Particularly, structure‐based rational PROTAC emerging types (e.g., homo‐PROTACs, multitargeting photo‐control PROTAC‐based conjugates) will be focused on.

Язык: Английский

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All-Visible-Light-Activated Dithienylethenes Induced by Intramolecular Proton Transfer

Journal of the American Chemical Society, Год журнала: 2019, Номер 141(46), С. 18467 - 18474

Опубликована: Окт. 28, 2019

The fast light-responsive dithienylethenes (DTEs) are one of the most attractive photochromic families because their excellent thermal irreversibility and fatigue resistance. However, all-visible-light-activated DTE system still remains challenging them require harmful high-energy ultraviolet light to trigger photocyclization reaction. Here, we have for first time borrowed a specific intramolecular proton transfer (IPT) process rationally designed series all-visible-light-driven DTEs. Incorporating IPT-functional group unit gives rise an extra absorption band with distinct red shift, which enables DTEs under stimuli visible at 450 nm, as well ensuring desirable photoswitching efficiency. isomerization from OH form NH induced by IPT can decrease energy gap excitation photocyclization, thereby affording all-visible-light-triggered performance, not only work in polar solvent but also show its effectiveness polymeric gel systems. In this regard, provide general reliable platform construct reversible broad applicability, especially avoiding use induce photocyclization.

Язык: Английский

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Action Plots in Action: In-Depth Insights into Photochemical Reactivity

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(50), С. 21113 - 21126

Опубликована: Дек. 3, 2021

Predicting wavelength-dependent photochemical reactivity is challenging. Herein, we revive the well-established tool of measuring action spectra and adapt technique to map wavelength-resolved covalent bond formation cleavage in what term "photochemical plots". Underpinned by tunable lasers, which allow excitation molecules with near-perfect wavelength precision, photoinduced several reaction classes have been mapped detail. These include cycloadditions based on photochemically generated o-quinodimethanes 1,3-dipoles such as nitrile imines well radical photoinitiator cleavage. Organized class, these data demonstrate that UV/vis fail act a predictor for at given most examined reactions, being strongly red shifted comparison absorption spectrum. We provide an encompassing perspective power plots bond-forming reactions their emerging applications design wavelength-selective photoresists photoresponsive soft-matter materials.

Язык: Английский

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