Coordination Chemistry Reviews, Год журнала: 2022, Номер 468, С. 214609 - 214609
Опубликована: Май 31, 2022
Язык: Английский
Journal of the American Chemical Society, Год журнала: 2020, Номер 142(35), С. 14789 - 14804
Опубликована: Авг. 7, 2020
Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital capacity in the conventional wavelength range (400–950 nm) been restricted by extremely limited tissue penetration. To tackle this challenge, novel approach using fluorescence second near-infrared window (NIR-II, 1000–1700 developed past decade to achieve deep penetration and high-fidelity imaging, thus significant applications have begun emerge. In Perspective, we first examine recent discoveries challenges development of NIR-II fluorophores compatible apparatuses. Subsequently, advances bioimaging, biosensing, therapy such cutting-edge technique are highlighted. Finally, based on achievement representative studies, elucidate main concerns regarding give some advice prospects future applications.
Язык: Английский
Процитировано
794
Chemical Society Reviews, Год журнала: 2020, Номер 49(22), С. 8179 - 8234
Опубликована: Янв. 1, 2020
Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.
Язык: Английский
Процитировано
593
Accounts of Chemical Research, Год журнала: 2019, Номер 52(9), С. 2559 - 2570
Опубликована: Авг. 22, 2019
Fluorescent sensing has emerged as a powerful tool for detecting various analytes and visualizing numerous biological processes by virtue of its superb sensitivity, rapidness, excellent temporal resolution, easy operation, low cost. Of particular interest is activity-based (ABS), burgeoning approach that actualized on the basis dynamic molecular reactivity rather than conventional lock-and-key recognition. ABS been recognized to possess some distinct advantages, such high specificity, extraordinary accurate signal outputs. A majority sensors are constructed modifying fluorogens, which strongly emissive when molecularly dissolved in solvents but experience emission quenching upon aggregate formation or concentration increase. The aggregation-caused (ACQ) phenomenon leads limited amount labeling analyte with sensor photobleaching resistance, could impede practical applications protocol. As an anti-ACQ phenomenon, aggregation-induced (AIE) provides straightforward solution ACQ problem. Thanks their intrinsic including threshold, signal-to-noise ratio, fluorescence turn-on nature, large Stokes shift, AIE-active luminogens (AIEgens) represent class fluorogen alternatives use AIEgen-involved can integrate advantages AIEgens ABS, additionally, AIE process offers unique properties approach. For instance, cases water-soluble chemical reaction not only chang color also causes solubility variations, result specific "light-up" signaling. In this Account, basic concepts mechanistic insights involving principle briefly summarized, then we highlight new breakthroughs, seminal studies, trends area have most recently reported our group. This emerging protocol successfully utilized array targets ions, small molecules, biomacromolecules, microenvironments, all closely relate human health, medical, public concerns. These detections smoothly achieved reactions (e.g., hydrolysis, boronate cleavage, dephosphorylation, addition, cyclization, rearrangement reactions) through different principles. these strategy generally shows good biocompatibility, selectivity, reliability contrast, indicating great potential high-tech innovations field, among bioprobing interest. With hope spark ideas inspire endeavors research area, further promoting state-of-the-art developments field sensing.
Язык: Английский
Процитировано
441
Aggregate, Год журнала: 2020, Номер 1(1), С. 80 - 106
Опубликована: Дек. 1, 2020
Abstract Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized precision medicine. By virtue good biocompatibility, outstanding fluorescence property, easy processability functionalization, promoted photosensitizing efficiency, well facile construction multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible vigorous vitality field theranostics. Numerous significant breakthroughs state‐of‐the‐art progression have been witnessed past few years. This review highlights aggregation‐enhanced superiorities AIE luminogens (AIEgens) disease theranostics mainly involving diagnostic imaging (fluorescence room temperature phosphorescence), therapeutic intervention (photodynamic therapy), feasibility based on experimental measurements theoretical simulations. Additionally, latest advanced developments AIEgens aspect corresponding strategies design highly effective AIE‐active through triggering aggregation formation are comprehensively summarized. Moreover, brief conclusion discussion current challenges future perspectives this area is further presented.
Язык: Английский
Процитировано
439
Advanced Materials, Год журнала: 2020, Номер 32(36)
Опубликована: Июль 30, 2020
Abstract Molecular science entails the study of structures and properties materials at level single molecules or small interacting complexes molecules. Moving beyond well‐defined complexes, aggregates (i.e., irregular clusters many molecules) serve as a particularly useful form that often display modified wholly new compared to their molecular components. Some unique phenomena such polymorphic aggregates, aggregation‐induced symmetry breaking, cluster excitons are only identified in few examples exotic features. Here, by virtue flourishing research on emission, concept “aggregate science” is put forward fill gaps between aggregates. Structures aggregate scale also systematically summarized. The structure–property relationships established for expected contribute technological development. Ultimately, may become an interdisciplinary field serves general platform academic research.
Язык: Английский
Процитировано
424
Chemical Reviews, Год журнала: 2021, Номер 122(1), С. 209 - 268
Опубликована: Окт. 19, 2021
In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.
Язык: Английский
Процитировано
386
Angewandte Chemie International Edition, Год журнала: 2020, Номер 60(14), С. 7476 - 7487
Опубликована: Июнь 9, 2020
Fluorescence imaging in the second near-infrared (NIR-II) window facilitated by aggregation-induced emission luminogens (AIEgens) is an emerging research field. NIR-II AIEgens overcome limitations imposed penetration depth and fluorescence efficiency, offering high-performance with enhanced precision. Some reported demonstrate capabilities for photoacoustic bimodal imaging, guided photothermal therapy, which not only improves diagnosis accuracy but provides efficient theranostic platform to accelerate preclinical translation as well. This minireview summarizes recent efforts on exploiting regard molecular design strategies bioapplications, puts forward current challenges promising prospects. timely sketch should benefit further exploitation of diverse multifunctional a wide array applications.
Язык: Английский
Процитировано
360
Journal of Materials Chemistry B, Год журнала: 2021, Номер 9(38), С. 7909 - 7926
Опубликована: Янв. 1, 2021
Photothermal therapy (PTT) has been widely applied in cancer as a result of its non-invasive, localized treatment and good therapeutic effect. In general, the final effect PTT mainly depends on photothermal materials, which can be further considered to determined by conversion efficiency, biocompatibility, stability materials. this review, materials including inorganic organic organic-inorganic composite recent years have summarized terms mechanism, preparation, applications. end, perspectives obstacles their development are overviewed.
Язык: Английский
Процитировано
285
Angewandte Chemie International Edition, Год журнала: 2019, Номер 59(10), С. 3793 - 3801
Опубликована: Окт. 1, 2019
Abstract Supramolecular assemblies have been very successful in regulating the photothermal conversion efficiency of organic materials a simple and flexible way, compared with conventional molecular synthesis. In these assemblies, it is inherent physiochemical mechanism that determines conversion, rather than assembly strategy. This Minireview summarizes supramolecular effects, which refer to unique features chemistry for efficiency. Emphasis placed on mechanisms how self‐assembly affects performance. The effects various types light‐harvesting species are discussed detail. timely interpretation promising future design high efficiency, precision, multiple functionalities wide array applications.
Язык: Английский
Процитировано
282
Angewandte Chemie International Edition, Год журнала: 2020, Номер 59(23), С. 8957 - 8962
Опубликована: Март 3, 2020
Novel BODIPY photosensitizers were developed for imaging-guided photodynamic therapy. The introduction of a strong electron donor to the core through phenyl linker combined with twisted arrangement between and acceptor is essential reducing energy gap lowest singlet excited state triplet (ΔEST ), leading significant enhancement in intersystem crossing (ISC) BODIPYs. Remarkably, BDP-5 smallest ΔEST (ca. 0.44 eV) exhibited excellent oxygen generation capabilities both organic aqueous solutions. also displayed bright emission far-red/near-infrared region condensed states. More importantly, vitro vivo studies demonstrated that NPs high potential cancer therapy bioimaging.
Язык: Английский
Процитировано
251