Collective
cell
migration
(CCM)
is
a
universal
process
that
responsible
for
various
biological
phenomena
in
living
organisms.
Therefore,
unraveling
the
mechanism
of
CCM
critical
understanding
principles
underlying
such
processes
and
their
application
biomaterials
biomedical
science.
Among
these
phenomena,
unjamming/jamming
transitions
are
particularly
intriguing
as
they
controlled
by
three
factors:
motility,
density,
cell–cell
adhesion.
However,
there
no
experimental
system
to
independently
demonstrate
control
effects.
In
this
study,
we
added
1,2-dimyristoyl-
sn
-glycero-3-phosphocholine
(DMPC)
nitrobenzene
droplet
containing
KI
I
2
develop
prototype
shows
self-propelled
motion
an
aqueous
trimethylstearylammonium
chloride
(TSAC)
solution.
First,
explored
relationship
between
motility
parameters,
namely,
concentrations
TSAC,
,
DMPC
size.
The
showed
directional
driven
Marangoni
convection
owing
solubilization
promoted
formation
mixed
micelles
filled
with
oil
TSA
+
;
notably,
could
be
each
parameter.
Furthermore,
interfacial
tension
(
γ
)
at
oil–water
interface,
measured
using
pendant
drop
method,
indicated
parameter
contributed
changes
.
Based
on
our
results,
inferred
dynamics
insertion
phase
into
self-assembled
membrane
covering
droplet,
well
solubilization,
important
factors
trigger
lead
motility.
developed
droplets
remained
stable
confluent
state,
wherein
were
contact
other
exhibited
polygonal
shapes
depending
size
density
because
protected
robust
layer.
results
morphology
controllable
system,
indirectly
altered
Thus,
procured
parameters
elucidate
transition
CCM.
This
can
biomodified
through
combination
phospholipids
any
biomolecule
enable
more
precise
evaluation
cells.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Self-propelling
active
matter
relies
on
the
conversion
of
energy
from
undirected,
nanoscopic
scale
to
directed,
macroscopic
motion.
One
challenges
in
design
synthetic
lies
control
dynamic
states,
or
motility
gaits.
Here,
an
experimental
system
self-propelling
droplets
with
thermally
controllable
and
reversible
states
is
presented,
unsteady
over
meandering
persistent
arrested
These
are
known
depend
Péclet
number
molecular
process
powering
motion,
which
can
now
be
tuned
by
using
a
temperature
sensitive
mixture
surfactants
as
propulsion
fuel.
The
droplet
dynamics
quantified
analyzing
flow
chemical
fields
for
individual
comparing
them
canonical
models
autophoretic
particles.
In
context
these
models,
situ,
fundamental
first
broken
symmetry
that
translates
isotropic,
immotile
base
state
self-propelled
motility,
experimentally
demonstrated.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Ноя. 25, 2021
Abstract
Random
fluctuations
are
inherent
to
all
complex
molecular
systems.
Although
nature
has
evolved
mechanisms
control
stochastic
events
achieve
the
desired
biological
output,
reproducing
this
in
synthetic
systems
represents
a
significant
challenge.
Here
we
present
an
artificial
platform
that
enables
us
exploit
stochasticity
direct
motile
behavior.
We
found
enzymes,
when
confined
fluidic
polymer
membrane
of
core-shell
coacervate,
were
distributed
stochastically
time
and
space.
This
resulted
transient,
asymmetric
configuration
propulsive
units,
which
imparted
motility
such
coacervates
presence
substrate.
mechanism
was
confirmed
by
modelling
simulations
silico.
Furthermore,
showed
deeper
understanding
could
be
utilized
modulate
motion
output.
Conceptually,
work
leap
design
philosophy
construction
with
life-like
behaviors.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(4), С. 4852 - 4861
Опубликована: Янв. 20, 2022
The
drift
or
fall
of
stretchable
neural
microelectrodes
from
the
surface
wet
and
dynamic
tissues
severely
hampers
adoption
for
electrophysiological
signal
monitoring.
Endowing
electrodes
with
adhesive
ability
is
an
effective
way
to
overcome
these
problems.
Current
adhesives
form
tough
adhesion
by
covalent
interaction,
which
decreases
biocompatibility
adhesives.
Here,
we
fabricate
a
strong
electrostatic
(noncovalent
interaction),
highly
conformal,
microelectrode
arrays
(MEAs)
interface.
This
MEA
was
composed
polypyrrole
(PPy)
as
electrode
material
hydrogel
substrate
[the
cross-linked
copolymerized
2-acrylamido-2-methylpropane
sulfonic
acid
(AMPS),
gelatin,
chitosan,
2-methoxyethyl
acrylate,
acrylic
named
PAGMA].
Strong
stable
(85
kPa)
high
stretchability
(100%)
allow
integration
PPy
MEAs
based
on
PAGMA
(PPy-PAGMA
MEAs)
diverse
tissues.
Additionally,
adjusting
concentration
AMPS
in
PAGMA,
(PAGMA-1)
can
produce
many
inorganic
elastomer
materials.
Finally,
PPy-PAGMA
were
toughly
conformally
adhered
rat's
subcutaneous
muscle
beating
heart,
signals
successfully
recorded.
development
offers
promising
strategy
establish
compliant
electrode-tissue
interfaces.
Communications Chemistry,
Год журнала:
2022,
Номер
5(1)
Опубликована: Июль 14, 2022
Unlike
molecular
crystals,
soft
self-assembled
fibers,
micelles,
vesicles,
etc.,
exhibit
a
certain
order
in
the
arrangement
of
their
constitutive
monomers
but
also
high
structural
dynamicity
and
variability.
Defects
disordered
local
domains
that
continuously
form-and-repair
structures
impart
to
such
materials
unique
adaptive
dynamical
properties,
which
make
them,
e.g.,
capable
communicate
with
each
other.
However,
objective
criteria
compare
complex
features
classify
supramolecular
are
non-trivial
attain.
Here
we
show
data-driven
workflow
allowing
us
achieve
this
goal.
Building
on
unsupervised
clustering
Smooth
Overlap
Atomic
Position
(SOAP)
data
obtained
from
equilibrium
dynamics
simulations,
can
variety
assemblies
via
robust
SOAP
metric.
This
provides
"defectometer"
different
types
based
ordered/disordered
environments
statistically
emerge
within
them.
Physical Chemistry Chemical Physics,
Год журнала:
2022,
Номер
24(39), С. 23980 - 24001
Опубликована: Янв. 1, 2022
Living
organisms
employ
chemical
self-organization
to
build
structures,
and
inspire
new
strategies
design
synthetic
systems
that
spontaneously
take
a
particular
form,
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(32)
Опубликована: Июнь 9, 2022
Abstract
Micellar
solubilization
is
a
transport
process
occurring
in
surfactant‐stabilized
emulsions
that
can
lead
to
Marangoni
flow
and
droplet
motility.
Active
droplets
exhibit
self‐propulsion
pairwise
repulsion
due
processes
and/or
products
raising
the
droplet's
interfacial
tension.
Here,
we
report
with
opposite
behavior,
wherein
decreases
tension
causes
attract.
We
characterize
influence
of
oil
chemical
structure,
nonionic
surfactant
concentration
on
tensions
flows
solubilizing
oil‐in‐water
drops.
Three
regimes
corresponding
“attraction”,
“repulsion”
or
“inactivity”
are
identified.
believe
these
studies
contribute
fundamental
understanding
provide
guidance
as
how
parameters
dynamics
chemotactic
interactions
between
active
droplets.
