Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Regenerative Biomaterials, Год журнала: 2023, Номер 10

Опубликована: Янв. 1, 2023

Abstract Ferroptosis, a completely new form of regulated cell death, is mainly caused by an imbalance between oxidative damage and reductive protection has shown great anti-cancer potential. However, existing small-molecule ferroptosis inducers have various limitations, such as poor water solubility, drug resistance low targeting ability, hindering their clinical applications. Nanotechnology provides opportunities for ferroptosis-driven tumor therapy. Especially, stimuli-responsive nanomaterials stand out among others been widely researched because unique spatiotemporal control advantages. Therefore, it’s necessary to summarize the application those in ferroptosis. Here, we describe physiological feature illustrate current challenges induce cancer Then, that are classified elaborated according external internal stimuli. Finally, future perspectives field proposed. We hope this review facilitates paving way design intelligent nano-ferroptosis inducers.

Язык: Английский

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A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions

Chemical Science, Год журнала: 2023, Номер 14(26), С. 7170 - 7184

Опубликована: Янв. 1, 2023

Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive species (ROS) hampers its therapeutic efficacy, especially against hypoxic solid tumors. In addition, some photosensitizers (PSs) have dark toxicity and are only activatable with short wavelengths such as blue or UV-light, which suffer from poor tissue penetration. Herein, we developed novel hypoxia-active PS operability in near-infrared (NIR) region based on conjugation cyclometalated Ru(ii) polypyridyl complex type [Ru(C^N)(N^N)2] NIR-emitting COUPY dye. The Ru(ii)-coumarin conjugate exhibits water-solubility, stability biological media high photostability along advantageous luminescent properties that facilitate both bioimaging phototherapy. Spectroscopic photobiological studies revealed this efficiently generates singlet superoxide radical anions, thereby achieving photoactivity toward cells upon highly-penetrating 740 nm light irradiation even under environments (2% O2). induction ROS-mediated cell death low-energy wavelength low exerted by could circumvent penetration issues while alleviating hypoxia limitation PDT. As such, strategy pave way development NIR- Ru(ii)-based theragnostic PSs fuelled tunable, molecular-weight fluorophores.

Язык: Английский

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Hemicyanine-Based Type I Photosensitizers for Antihypoxic Activatable Photodynamic Therapy

ACS Materials Letters, Год журнала: 2023, Номер 5(11), С. 3058 - 3067

Опубликована: Окт. 20, 2023

Type I photosensitizers provide great potential for effective antihypoxia cancer treatment because of their low O2 reliance. To achieve tumor specificity, activatable type that can selectively respond to tumor-related stimuli and thereafter activate phototoxicity are urgently required, which however rare. We herein report a hemicyanine-based scaffold with photoreactions antihypoxic PDT against tumors. The common hemicyanine (Cy) endows minimized ROS generation, be nicely tuned boost production by introducing the halogens increase spin–orbit coupling (SOC) constant thus favor intersystem crossing (ISC) rate. optimized CyBr is further modified an probe (CyBrP) specifically unlock its fluoro-photoacoustic signals upon interaction alkaline phosphatase (ALP) overexpressed in By virtue high sensitivity selectivity toward ALP as well O2-dependence CyBrP allows precise phototheranostics tumors, leading effectively suppressed growth living mice. Therefore, this study presents facile halogen-substituted strategy construct serve universal scaffolds PDT.

Язык: Английский

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Unique Properties and Emerging Applications of Carbolong Metallaaromatics

Accounts of Chemical Research, Год журнала: 2023, Номер 56(8), С. 924 - 937

Опубликована: Янв. 31, 2023

ConspectusAromatic compounds are important in synthetic chemistry, biomedicines, and materials science. As a special type of aromatic complex, transition-metal-based metallaaromatics contain at least one transition metal an framework. The chemistry has seen much progress computational studies methods, but their properties applications still emerging. In recent years, we have disclosed series metal-centered conjugated polycyclic metallacycles which carbon chain is chelated to center through three metal-carbon bonds. These termed carbolong complexes exhibit good stability water, oxygen, light, heat on account polydentate chelation aromaticity, making them easy handle. Carbolong not only π-conjugated aromatics also organometallics; therefore, they the both species. this Account, showcase advances based different properties.First, kind aromatic, with ability transmit electrons, allowing function as single-molecule conductors candidates for electron transporting layer (ETLs) solar cells. A been proved be useful achievable ETLs enhance device performance organic cells perovskite cells.Second, due involvement d orbitals conjugation, normally strong broad absorption, even some cases extending near-infrared region (NIR). absorbed optical energy can converted into heat, ultrasound; consequently, used core moieties smart materials. For example, 7C were found aggregation-enhanced emission (AIEE). Some 12C designed NIR-responsive polymers, such cylindrical materials, self-healing shape memory contrast stereotypically toxic osmium highly OsO4, low cell cytotoxicity biocompatibility; potential biomedical area. benefiting from absorption NIR, 9C photoacoustic imaging photothermal therapy, respectively. addition, photodynamic therapeutic take advantage peroxo complex discussed.Third, transition-metal by carbon-based ligands, displayed catalytic activity dehydrogenation alcohols bimetallic catalyze difunctionalization reactions unactivated alkenes.Overall, applied photovoltaics, phototherapy, reactions. Moving forward, hope that Account will shed light future theoretical research encourage more discoveries other metallaaromatics.

Язык: Английский

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A Multifunctional Nanozyme with NADH Dehydrogenase‐Like Activity and Nitric Oxide Release under Near‐Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(25)

Опубликована: Июнь 16, 2023

In recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need develop new antibacterial agents effectively treat AMR infection. Herein, a novel nanozyme platform (Cu,N-GQDs@Ru-NO) prepared, where Cu,N-doped graphene quantum dots (Cu,N-GQDs) are covalently functionalized with nitric oxide (NO) donor, ruthenium nitrosyl (Ru-NO). Under 808 nm near-infrared (NIR) light irradiation, Cu,N-GQDs@Ru-NO demonstrates nicotinamide adenine dinucleotide (NADH) dehydrogenase-like activity for photo-oxidizing NADH NAD+ , thus disrupting redox balance in bacterial cells and resulting death; meanwhile, onsite NIR light-delivered NO eradicates methicillin-resistant Staphylococcus aureus (MRSA) biofilms, promotes wound healing; furthermore, shows excellent photothermal effect that enhances efficacy as well. With combination dehydrogenase activity, therapy, gas displays both vitro vivo MRSA infection biofilm eradication, which provides therapeutic modality treating inflammatory wounds.

Язык: Английский

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Near‐Infrared Self‐Assembled Hydroxyl Radical Generator Based on Photoinduced Cascade Electron Transfer for Hypoxic Tumor Phototherapy

Advanced Materials, Год журнала: 2023, Номер 35(44)

Опубликована: Авг. 7, 2023

The hydroxyl radical (•OH) is an extremely potent reactive oxygen species that plays a crucial role in photooxidations within the realm of hypoxic tumor therapy. However, current methods for •OH photogeneration typically rely on inorganic materials require UV/vis light excitation. Consequently, photogenerators based organic molecules, especially those utilizing near-infrared (NIR) excitation, are rare. In this study, concept photoinduced cascade charge transfer (PICET), which utilizes NIR heavy-atom-free photosensitizers (ANOR-Cy5) to generate introduced. ANOR-Cy5 photosensitizer, with its flexible hydrophobic structure, enables formation nanoparticles aqueous solutions through molecular assembly. PICET involves symmetry-breaking separation-induced localized charge-separated state, transitioning delocalized governs efficiency generation. Thanks oxygen-independent nature generation and robust oxidative properties, ANOR-Cy5-based photosensitizer demonstrates highly effective anti-cancer effects, even under severely conditions. This discovery emphasizes potential achieving using single molecule engineering self-assembly, thereby opening up new possibilities phototherapy beyond.

Язык: Английский

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A review on ferroptosis and photodynamic therapy synergism: Enhancing anticancer treatment

Heliyon, Год журнала: 2024, Номер 10(7), С. e28942 - e28942

Опубликована: Март 31, 2024

Ferroptosis is an iron-dependent programmed cell death modality, which has showed great potential in anticancer treatment. Photodynamic therapy (PDT) widely used clinic as therapy. PDT combined with ferroptosis-promoting been found to be a promising strategy improve anti-cancer efficacy. Fenton reaction ferroptosis can provide oxygen for PDT, and produce reactive species enhance ferroptosis. In this review, we briefly present the importance of treatment, mechanism ferroptosis, researches on induced synergistic effect cancer killing.

Язык: Английский

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Iron-Based Nanovehicle Delivering Fin56 for Hyperthermia-Boosted Ferroptosis Therapy Against Osteosarcoma

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 91 - 107

Опубликована: Янв. 1, 2024

Background: Although systemic chemotherapy is a standard approach for osteosarcoma (OS) treatment, its efficacy limited by the inherent or acquired resistance to apoptosis of tumor cells. Ferroptosis considered as an effective strategy capable stimulating alternative pathways cancer cell demise. The purpose this study develop novel boosting ferroptotic cascade synergistic therapy. Methods and Results: A nanovehicle composed arginine-glycine-aspartate (RGD) modified mesoporous silica-coated iron oxide loading Fin56 was rationally prepared (FSR-Fin56). With RGD-mediated targeting affinity, FSR-Fin56 could achieve selective accumulation accurate delivery cargos into Upon exposure NIR light, generate localized hyperthermia disintegrate liberate therapeutic payload. released triggered degradation GPX4, while Fe 3+ depleted intracellular GSH pool, producing 2+ Fenton agent. local rise in temperature, conjunction with -mediated reaction, led rapid significant ROS, culminating LPOs death. outstanding safety were validated both vitro vivo. Conclusion: Fin56-loaded FSR effectively disturb redox balance Coupled laser irradiation, cooperative CDT PTT achieved boosted ferroptosis-inducing Taken together, offers compelling particularly ferroptosis-sensitive tumors like osteosarcoma. Keywords: chemodynamic therapy, photothermal Fin56, ferroptosis

Язык: Английский

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Chemiluminescent transition metal complexes: Mechanisms and applications

Coordination Chemistry Reviews, Год журнала: 2025, Номер 530, С. 216495 - 216495

Опубликована: Фев. 5, 2025

Язык: Английский

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Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy

Cancers, Год журнала: 2023, Номер 15(20), С. 5043 - 5043

Опубликована: Окт. 19, 2023

Ferroptosis is a programmed death mode that regulates redox homeostasis in cells, and recent studies suggest it promising of tumor cell death. regulated by iron metabolism, lipid intracellular reducing substances, which the mechanism basis its combination with photodynamic therapy (PDT). PDT generates reactive oxygen species (ROS) 1O2 through type I II photochemical reactions, subsequently induces ferroptosis Fenton reaction peroxidation membrane lipids. kills cells generating excessive cytotoxic ROS. Due to limited laser depth photosensitizer enrichment, systemic treatment effect not good. Combining can compensate for these shortcomings. Nanoparticles constructed photosensitizers agonists are widely used field therapy, their targeting biological safety be improved modification. These nanoparticles only directly kill but also further exert synergistic activating antitumor immunity, improving hypoxia microenvironment, inhibiting angiogenesis. Ferroptosis-agonist-induced chemotherapy PDT-induced ablation have good clinical application prospects. In this review, we summarize current research progress on how promote each other.

Язык: Английский

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