Factors Affecting Variation of the Human Gut Phageome DOI

Ciara A. Tobin,

Colin Hill, Andrey N. Shkoporov

и другие.

Annual Review of Microbiology, Год журнала: 2023, Номер 77(1), С. 363 - 379

Опубликована: Июнь 12, 2023

The gut microbiome is a dense and metabolically active consortium of microorganisms viruses located in the lower gastrointestinal tract human body. Bacteria their (phages) are most abundant members microbiome. Investigating biology interplay between two important if we to understand roles health disease. In this review, summarize recent advances resolving taxonomic structure ecological functions complex community phages gut-the phageome. We discuss how age, diet, geography can all have significant impact on phageome composition. note that alterations been observed several diseases such as inflammatory bowel disease, irritable syndrome, colorectal cancer, evaluate whether these changes directly or indirectly contribute disease etiology pathogenesis. also highlight lack standardization studying has contributed variation reported results.

Язык: Английский

Omega-3 fatty acids and the gut microbiome: a new frontier in cardiovascular disease prevention DOI Creative Commons
Vikram Kumar,

Alka Rohilla,

Jayesh J. Ahire

и другие.

Deleted Journal, Год журнала: 2025, Номер 2(1)

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

1
Induction mechanisms and strategies underlying interprophage competition during polylysogeny DOI Creative Commons
Justin E. Silpe, Olivia P. Duddy, Bonnie L. Bassler

и другие.

PLoS Pathogens, Год журнала: 2023, Номер 19(5), С. e1011363 - e1011363

Опубликована: Май 18, 2023

Phages play central roles in shaping bacterial community biology.For example, lytic phages, by eliminating particular subpopulations of bacteria, control the composition biofilm communities [1][2][3].Temperate phages can infect and persist a state called lysogeny [4].As inhabitants, lysogenic drive genome evolution via introduction viral genes that endow hosts with new capabilities or regulate host biochemical signaling pathways.For instance, some cyanophages encode photosystem components enhance light harvesting ability [5,6].In Shigella flexneri, phage-encoded enzymes modify O-antigen sugars enabling serotype conversion [7].Similarly, phage hydrolyze polysaccharide Acinetobacter baumannii capsule, altering formation [8].Underscoring their importance to human health, temperate supply toxin-encoding responsible for diseases including cholera (caused CTX Vibrio cholerae), dysentery STX Escherichia coli), diphtheria beta Corynebacterium diphtheriae), botulism neurotoxin-encoding Clostridium botulinum) [9][10][11][12].These other examples highlight fascinating connections between biology biology.In cases, infection confers benefits bacterium, enhancing colonization dissemination from eukaryotic hosts.Phages are also frequently parasites, and, consequently, bacteria under pervasive threat exploit resources continued propagation moreover, kill response conditions.Following infection, undertake one two lifestyle programs (Fig 1) [13,14].They enter cycle which uses replicate package its into particles.The particles subsequently released, killing cell promoting cells.Alternatively, exist as prophages [13,14].Commonly, integrates DNA at discrete site genome.Less commonly, remains an extrachromosomal element plasmid-like [15,16].In both prophage replication during division ensures transmission progeny.Phages enact typically convert route when bacterium experiences stress.The canonical trigger lysogeny-to-lysis transition is activation SOS following damage [13,14,17].The notion tuning SOS, connects decision-making vitality.Phages thereby "abandon" current long-term survivability becomes uncertain.

Язык: Английский

Процитировано

19
Fecal virome transfer improves proliferation of commensal gut Akkermansia muciniphila and unexpectedly enhances the fertility rate in laboratory mice DOI Creative Commons
Torben Sølbeck Rasmussen, Caroline M. Junker Mentzel, Malene Refslund Danielsen

и другие.

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Май 7, 2023

Probiotics are intended to improve gastrointestinal health when consumed. However, the probiotics marketed today only colonize densely populated gut a limited extent. Bacteriophages comprise majority of viruses in human virome and there strong indications that they play important roles shaping microbiome. Here, we investigate use fecal transplantation (FVT, sterile filtrated feces) as mean alter microbiome composition lead way for persistent colonization two types probiotics: Lacticaseibacillus rhamnosus GG (LGG) representing well-established probiotic Akkermansia muciniphila (AKM) putative next-generation probiotic. Male female C57BL/6NTac mice were cohoused pairs from 4 weeks age received following treatment by oral gavage at week 5 6: AKM+FVT, LGG+FVT, sham (Pro-sham)+FVT, LGG+Saline, AKM+Saline, control (Pro-sham+Saline). The FVT donor material originated with high relative abundance A. muciniphila. All animals terminated 9 weeks. did not increase administered LGG or AKM recipient mice. Instead significantly (p < 0.05) increased naturally occurring compared control. This highlights potential propagating existing commensal “probiotics” have already permanently colonized gut. Being co-housed male female, fraction became pregnant. Unexpectedly, treated found higher fertility rate independent administration. These preliminary observations urge follow-up studies investigating interactions between fertility.

Язык: Английский

Процитировано

18
The human gut phageome: composition, development, and alterations in disease DOI Creative Commons
Yingying Zhang,

Ran Wang

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Июль 5, 2023

The human gastrointestinal tract is colonized by a large number of microorganisms, including bacteria, archaea, viruses, and eukaryotes. bacterial community has been widely confirmed to have significant impact on health, while particularly phages, received less attention. Phages are viruses that specifically infect bacteria. They abundant in the biosphere exist symbiotic relationship with their host Although application high-throughput sequencing bioinformatics technology greatly improved our understanding genomic diversity, taxonomic composition, spatio-temporal dynamics gut phageome, there still portion data uncharacterized. Preliminary studies predicted phages play crucial role driving microbial ecology evolution. Prior exploring function it necessary address obstacles hinder establishing comprehensive database sufficient biological properties phage-bacteria interactions health. In this study, we provide an overview its structure, development. We also explore various factors may influence phageome based current research, age, diet, ethnicity, geographical location. Additionally, summarize between diseases, such as IBD, IBS, obesity, diabetes, metabolic syndrome.

Язык: Английский

Процитировано

18
Evidence for the contribution of the gut microbiome to obesity and its reversal DOI
Douwe F. de Wit, Nordin M.J. Hanssen, Koen Wortelboer

и другие.

Science Translational Medicine, Год журнала: 2023, Номер 15(723)

Опубликована: Ноя. 22, 2023

Obesity has become a worldwide pandemic affecting more than 650 million people and is associated with high burden of morbidity. Alongside traditional risk factors for obesity, the gut microbiome been identified as potential factor in weight regulation. Although rodent studies suggest link between body weight, human evidence causality remains scarce. In this Review, we postulate that existing to establish contribution development obesity humans but modified probiotic strains supraphysiological dosages microbial metabolites may be beneficial combatting obesity.

Язык: Английский

Процитировано

17
Therapeutic applications of gut microbes in cardiometabolic diseases: current state and perspectives DOI Creative Commons
Yuan Lin, Ying Li, Moutong Chen

и другие.

Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1)

Опубликована: Янв. 20, 2024

Язык: Английский

Процитировано

8
Bacteriophages, gut bacteria, and microbial pathways interplay in cardiometabolic health DOI Creative Commons
Daniel Kirk, Ricardo Costeira, Alessia Visconti

и другие.

Cell Reports, Год журнала: 2024, Номер 43(2), С. 113728 - 113728

Опубликована: Янв. 31, 2024

Cardiometabolic diseases are leading causes of mortality in Western countries. Well-established risk factors include host genetics, lifestyle, diet, and the gut microbiome. Moreover, bacterial communities their activities can be altered by bacteriophages (also known simply as phages), bacteria-infecting viruses, making these biological entities key regulators human cardiometabolic health. The manipulation populations phages enables possibility using treatment through phage therapy fecal viral transplants. First, however, a deeper understanding role phageome is required. In this review, we first introduce component microbiome discuss transplants relation to diseases. We then summarize current state research propose how might indirectly influence health bacteria metabolites.

Язык: Английский

Процитировано

8
Prevalence of metabolic syndrome in patients with inflammatory bowel disease: a systematic review and meta-analysis DOI Creative Commons
Zhaofeng Shen, Mengyuan Zhang, Yijing Liu

и другие.

BMJ Open, Год журнала: 2024, Номер 14(3), С. e074659 - e074659

Опубликована: Март 1, 2024

Patients with inflammatory bowel disease (IBD) may experience comorbidities involving metabolic syndrome (MetS). However, this association remains controversial. Our objective was to estimate the prevalence of MetS in patients IBD and assess whether is more strongly associated ulcerative colitis (UC) or Crohn's (CD).

Язык: Английский

Процитировано

7
The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications—2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum DOI Creative Commons
Mariana X. Byndloss, Suzanne Devkota, Frank A. Duca

и другие.

Diabetes Care, Год журнала: 2024, Номер unknown

Опубликована: Июнь 24, 2024

This article summarizes the state of science on role gut microbiota (GM) in diabetes from a recent international expert forum organized by Diabetes, Diabetes Care, and Diabetologia, which was held at European Association for Study 2023 Annual Meeting Hamburg, Germany. Forum participants included clinicians basic scientists who are leading investigators field intestinal microbiome metabolism. Their conclusions were as follows: 1) GM may be involved pathophysiology type 2 diabetes, microbially produced metabolites associate both positively negatively with disease, mechanistic links functions (e.g., genes butyrate production) glucose metabolism have recently emerged through use Mendelian randomization humans; 2) highly individualized nature poses major research obstacle, large cohorts deep-sequencing metagenomic approach required robust assessments associations causation; 3) because single-time point sampling misses intraindividual dynamics, future studies repeated measures within individuals needed; 4) much will to determine applicability this expanding knowledge diagnosis treatment, novel technologies improved computational tools important achieve goal.

Язык: Английский

Процитировано

7
The Human Gut Virome and Its Relationship with Nontransmissible Chronic Diseases DOI Open Access

Shahrzad Ezzatpour,

Alicia del Carmen Mondragón, Alejandra Cardelle‐Cobas

и другие.

Nutrients, Год журнала: 2023, Номер 15(4), С. 977 - 977

Опубликована: Фев. 15, 2023

The human gastrointestinal tract contains large communities of microorganisms that are in constant interaction with the host, playing an essential role regulation several metabolic processes. Among gut microbial communities, bacteriome has been most widely studied recent decades. However, years, there increasing interest studying influences other groups can exert on host. them, virome is attracting great because viruses interact host immune system and functions; this also case for phages, which bacterial microbiota. antecedents virome-rectification-based therapies among various diseases were investigated. In near future, stool metagenomic investigation should include identification bacteria as well their correlation networks, to better understand microbiota activity disease progression.

Язык: Английский

Процитировано

15