Humoral Immune Responses in Patients with Severe COVID-19: A Comparative Pilot Study between Individuals Infected by SARS-CoV-2 during the Wild-Type and the Delta Periods DOI Creative Commons
Maria G. Sukhova, Maria G. Byazrova, Artem A. Mikhailov

и другие.

Microorganisms, Год журнала: 2023, Номер 11(9), С. 2347 - 2347

Опубликована: Сен. 20, 2023

Since the onset of COVID-19 pandemic, humanity has experienced spread and circulation several SARS-CoV-2 variants that differed in transmissibility, contagiousness, ability to escape from vaccine-induced neutralizing antibodies. However, issues related differences variant-specific immune responses remain insufficiently studied. The aim this study was compare parameters humoral two groups patients with acute who were infected during period D614G Delta SARS-CoV-2. Sera 48 tested for binding antibodies using six assays. We found serum samples demonstrated 3.9- 1.6-fold increases RBD- spike-specific IgG wild-type antigens compared variant (p < 0.01). Cluster analysis showed existence well-separated clusters. first cluster mainly consisted D614G-period second predominantly included period. results thus obtained indicate D614G- Delta-specific infections can be characterized by signatures. This taken into account when developing new vaccines.

Язык: Английский

SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner DOI Creative Commons
Wonyeong Jung,

Arturo Abdelnour,

Paulina Kapłonek

и другие.

Cell Reports, Год журнала: 2024, Номер 43(9), С. 114684 - 114684

Опубликована: Авг. 30, 2024

Immunity acquired by vaccination following infection, termed hybrid immunity, has been shown to confer enhanced protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhancing the breadth and potency of immune responses. Here, we assess Fc-mediated humoral profiles in immunity their association with age vaccine type. Participants are divided into three groups: infection only, (i.e., immunity). Using systems serology, profile responses spikes subdomains SARS-CoV-2 variants. We find that is characterized superior Fc receptor binding natural killer (NK) cell-, neutrophil-, complement-activating antibodies, which higher than what can be expected from sum infection. These differences between vaccine-induced more pronounced aged adults, especially for immunoglobulin (Ig)G1, IgG2, Fcγ receptor-binding antibodies. Our findings suggest strategies aim mimic should consider as an important modifier.

Язык: Английский

Процитировано

0
Navigating the Landscape of B Cell Mediated Immunity and Antibody Monitoring in SARS-CoV-2 Vaccine Efficacy: Tools, Strategies and Clinical Trial Insights DOI Creative Commons
Sophie O’Reilly, Joanne Byrne, Eoin R. Feeney

и другие.

Vaccines, Год журнала: 2024, Номер 12(10), С. 1089 - 1089

Опубликована: Сен. 24, 2024

Correlates of Protection (CoP) are biomarkers above a defined threshold that can replace clinical outcomes as primary endpoints, predicting vaccine effectiveness to support the approval new vaccines or follow up studies. In context COVID-19 vaccination, CoPs help address challenges such demonstrating in special populations, against emerging SARS-CoV-2 variants determining durability vaccine-elicited immunity. While anti-spike IgG titres and viral neutralising capacity have been characterised for contribution other components humoral immune response immediate long-term protective immunity is less well characterised. This review examines evidence supporting use trials, how they be used define It also highlights alternative biomarkers, including Fc effector function, mucosal immunity, generation long-lived plasma memory B cells discuss these applied studies tools available study them.

Язык: Английский

Процитировано

0
The PreS-Based Recombinant Vaccine VVX001 Induces Hepatitis B Virus Neutralizing Antibodies in a Low-Responder to HBsAg-Based HBV Vaccines DOI Creative Commons
Inna Tulaeva, Felix Lehmann, Nora Goldmann

и другие.

Vaccines, Год журнала: 2024, Номер 12(10), С. 1123 - 1123

Опубликована: Сен. 30, 2024

Approximately 10-20% of subjects vaccinated with HBsAg-based hepatitis B virus (HBV) vaccines are non-responders. BM32 is a recombinant grass pollen allergy vaccine containing the HBV-derived preS surface antigen as an immunological carrier protein. PreS includes binding site HBV to its receptor on hepatocytes. We investigated whether non-responsiveness after repeated vaccinations could be overcome by immunization VVX001 (i.e., alum-adsorbed BM325, component BM32).

Язык: Английский

Процитировано

0
Unveiling unique effector function-related bulk antibody profiles in long-term hemodialysis patients following COVID-19 mRNA booster vaccination DOI Creative Commons

Chia-Yi Chou,

Chung‐Yi Cheng, Chih‐Hsin Lee

и другие.

Journal of Microbiology Immunology and Infection, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0
Humoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platform DOI Creative Commons
Xin Tong, Benjamin P. Kellman, María José Avendaño

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

Abstract SARS-CoV-2 vaccine-acquired immunity provides robust cross-variant recognition, while infection-acquired can be heterogenous, with disease severity often modulating post-recovery responses. We assessed antibody waning dynamics between infection- and vaccination-acquired across variants of concern (VOC). mRNA vaccination induced potent, cross-VOC Spike recognition functional responses, but waned more rapidly for Omicron Spike. Hospitalized individuals developed durable responses lower peaks compared to vaccination, outpatients exhibited slower decay than inactivated vaccine recipients. Humoral the receptor binding domain tracked neutralizing titers, S2-directed antibody-dependent myeloid cellular phagocytosis. Boosting recovered patients or vaccines expanded humoral breadth, durability, restored eliminating severity- platform-associated differences. Therefore, hybrid immunization compensates this distinction broadens highlighting value boosting in previously infected individuals. One Sentence Summary Infection- COVID-19 exhibit different profiles, each characterized by distinct kinetics over time.

Язык: Английский

Процитировано

0
Humoral Immune Responses in Patients with Severe COVID-19: A Comparative Study between Individuals Infected by SARS-CoV-2 during the Wild-Type and the Delta Periods DOI Open Access

Maria M Sukhova,

Maria G. Byazrova, Artem A. Mikhailov

и другие.

Опубликована: Авг. 14, 2023

Since the onset of COVID‐19 pandemic, humanity has experienced spread and circulation several SARS-CoV-2 variants that differed in transmissibility, contagiousness, ability to escape from vaccine-induced neutralizing antibodies. However, issues related differences variant-specific immune responses, remain insufficiently studied. The aim this study was compare parameters humoral responses two groups patients with acute COVID-19 who were infected during period D614G Delta SARS-CoV-2. Sera 48 tested for binding antibodies using six assays. We found serum samples demonstrated 3.9‐ 1.6‐fold increase RBD- Spike‐specific IgG Wild type antigens compared variant (p &amp;lt; 0.01). Cluster analysis showed existence well-separated clusters. first cluster mainly consisted second predominantly included period. results thus obtained indicate D614G- Delta-specific infections can be characterized by signatures. This taken into account when developing new vaccines.

Язык: Английский

Процитировано

0
Humoral Immune Responses in Patients with Severe COVID-19: A Comparative Pilot Study between Individuals Infected by SARS-CoV-2 during the Wild-Type and the Delta Periods DOI Creative Commons
Maria G. Sukhova, Maria G. Byazrova, Artem A. Mikhailov

и другие.

Microorganisms, Год журнала: 2023, Номер 11(9), С. 2347 - 2347

Опубликована: Сен. 20, 2023

Since the onset of COVID-19 pandemic, humanity has experienced spread and circulation several SARS-CoV-2 variants that differed in transmissibility, contagiousness, ability to escape from vaccine-induced neutralizing antibodies. However, issues related differences variant-specific immune responses remain insufficiently studied. The aim this study was compare parameters humoral two groups patients with acute who were infected during period D614G Delta SARS-CoV-2. Sera 48 tested for binding antibodies using six assays. We found serum samples demonstrated 3.9- 1.6-fold increases RBD- spike-specific IgG wild-type antigens compared variant (p < 0.01). Cluster analysis showed existence well-separated clusters. first cluster mainly consisted D614G-period second predominantly included period. results thus obtained indicate D614G- Delta-specific infections can be characterized by signatures. This taken into account when developing new vaccines.

Язык: Английский

Процитировано

0