Sonocatalytic cancer therapy: theories, advanced catalysts and system design

Nanoscale, Год журнала: 2023, Номер 15(48), С. 19407 - 19422

Опубликована: Янв. 1, 2023

Sonocatalytic cancer therapy has emerged as a promising strategy through the combination of ultrasound waves and catalytic materials to selectively target destroy cells.

Язык: Английский

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Modulating the Electronic Structure of MnNi₂S₃ Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen‐Immunotherapy

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Hydrogen (H 2 ) therapy has demonstrated antitumor effect, but the therapeutic efficacy is restricted by low solubility and nontarget delivery of H . Electrolysis O electrocatalysts sustainably releases enormous amounts inspires precise for tumor therapy. Herein, manganese‐doped Ni S 3 nanoelectrodes (MnNi NEs) are designed electrocatalytic activation immunity to effectively potentiate ‐immunotherapy. atoms featuring empty 3d orbitals reduce initial energy barrier hydrogen evolution reaction (HER) promoting adsorption O. Moreover, Mn with different electronegativity modulate electronic structure facilitate desorption generated , thus enhancing HER activity MnNi NEs. Based on high activity, controllable (EHT) achieved in a voltage‐dependent manner. Mechanistically, NE‐mediated EHT induces mitochondrial dysfunction oxidative stress, which subsequently activates pyroptosis through typical ROS/caspase‐1/GSDMD signaling pathway. Furthermore, enhances infiltration CD8 + T lymphocytes into tumors reverses immunosuppressive microenvironment. This work demonstrates an electrocatalyst synergistic gas‐immunotherapy, may spark electrocatalyst‐based strategies.

Язык: Английский

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Exogenous Electron Generation Techniques for Biomedical Applications: Bridging Fundamentals and Clinical Practice

Biomaterials, Год журнала: 2025, Номер 317, С. 123083 - 123083

Опубликована: Янв. 5, 2025

Язык: Английский

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Nano-Radiopharmaceuticals in Colon Cancer: Current Applications, Challenges, and Future Directions

Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 257 - 257

Опубликована: Фев. 14, 2025

Colon cancer remains a significant global health challenge; however, the treatment outcome for colon patients can be improved through early detection and effective treatment. Nano-radiopharmaceuticals, combining nanotechnology with radiopharmaceuticals, are emerging as revolutionary approach in both diagnostic imaging therapy, playing role management of patients. This review examines use nano-radiopharmaceuticals diagnosis cancer, highlighting current applications, challenges, future directions. Nanocarriers radionuclides have shown potential improving treatment, including liposomes, microparticles, nanoparticles, micelles, dendrimers, hydrogels, which approved by FDA. These nanocarriers deliver targeted drugs into malignant cells without affecting normal cells, reducing side effects. Antibody-guided systemic radionuclide-targeted therapy has treating cancer. Novel nanomedicines, like Hensify 32P BioSilicon, under clinical development radiation delivery percutaneous intratumoral injections. Although using is superior technique diagnosing there limitations such unintentional accumulation nanoparticles healthy tissues, leads to toxicity due biodistribution issues, well high manufacturing costs that limit their availability However, direction moving toward providing more precise crucial enhancing production costs.

Язык: Английский

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A self-powered electromodulative system based on an abiotic-biotic hybrid for cancer catalytic therapy

Опубликована: Фев. 1, 2025

Язык: Английский

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