Colloidal Hydrogel for Sensitizing Microwave Ablation‐Induced in Situ Tumor Vaccination and Modulating Innate and Adaptive Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Июнь 5, 2024

Abstract Drawing inspiration from recent advances in microwave ablation (MWA) induced situ tumor vaccination, a colloidal hydrogel comprising amphoteric gelatin nanoparticles and poly (acrylic acid) (PAA)‐calcium carbonate nanorods (PAA‐CaCO 3 NRs) is developed to deliver the microwave‐sensitive agent sodium fluoride (NaF) which can also act as glycolysis inhibitor conjunction with blockade of T‐cell Ig ITIM domain (TIGIT), coinhibitory receptor expressed by both natural killer (NK) cells T cells. The combination NaF (MW) thermal‐dynamic sensitization effectively reversed acidic immunosuppressive microenvironment (TME). Moreover, incorporation anti‐TIGIT monoclonal antibody (aTIGIT) molecules amplified innate adaptive immune responses counteracting exhaustion NK effective CD8 + This augmentation resulted enhanced elimination suppression metastasis recurrence. Thus, this study underscores potential hydrogel‐sensitized MWA therapy, aTIGIT treatments, promising clinical strategy for cancer vaccination.

Язык: Английский

---

N6-methyladenosine (m6A) Writer WTAP Potentiates Hepatocellular Carcinoma Immune Evasion and Aerobic Glycolysis

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown

Опубликована: Июнь 13, 2024

Язык: Английский

---

Recent Progress of Multifunctional Molecular Probes for Triple-Negative Breast Cancer Theranostics

Pharmaceutics, Год журнала: 2024, Номер 16(6), С. 803 - 803

Опубликована: Июнь 14, 2024

Breast cancer (BC) poses a significant threat to women’s health, with triple-negative breast (TNBC) representing one of the most challenging and aggressive subtypes due lack estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2) expression. Traditional TNBC treatments often encounter issues such as low drug efficiency, limited tumor enrichment, substantial side effects. Therefore, it is crucial explore novel diagnostic treatment systems for TNBC. Multifunctional molecular probes (MMPs), which integrate target recognition well therapeutic functions, introduce advanced tools theranostics. Using an MMP system, drugs can be precisely delivered site through targeted ligand. Real-time dynamic monitoring release achieved using imaging technology allows evaluation enrichment at site. This approach enables accurate release, thereby improving effect. this review summarizes recent advancements in MMPs theranostics, encompassing design synthesis their applications field

Язык: Английский

---

“Internal Trouble and Outside Aggression” Strategy: Energy Deprivation Synergized With cGAS‐STING Pathway Activation for Stimuli‐Responsive Photodynamic‐Metal‐Metabolic Immunotherapy

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Abstract The aberrant metabolic activities of tumor cells not only facilitate proliferation but also impair immune cell function and cause an immunosuppressive microenvironment (TME). Thus, reshaping the TME while activating innate immunity is highly desirable challenging. Herein, a multifunctional immunomodulator engineered for near‐infrared light (NIR)‐triggered photodynamic‐metal‐metabolic immunotherapy via “internal trouble outside aggression” strategy. Specifically, endogenous exogenous stimuli‐responsive nanoagent prepared consisting photosensitizer chlorin e6 (Ce6) modified dense silica‐coated rare earth‐doped nanoparticles (ReNPs@SiO 2 (Ce6)), with in situ grown ZIF‐8 on surface loading glucose transporter‐1 (GLUT‐1) inhibitor Fasentin glutaminase‐1 bis‐2‐(5‐phenylacetamido‐1,3,4‐thiadiazol‐2‐yl)ethyl sulfide (BPTES). as‐obtained final product denoted as ReSZ(FB). ReSZ(FB) induces‐ mitochondrial damage releases DNA (mtDNA) NIR‐mediated PDT. Subsequently, Zn 2+ from collaborates mtDNA to activate cGAS‐STING pathway, initiating robust tumor‐specific response. Concurrently, BPTES triggeres energy deprivation by blocking uptake inhibiting glutamine decomposition, thereby reprogramming TME, alleviating immunosuppression. Tumor are damaged trapped into trouble” combining PDT deprivation, sharply enhanced lethality exposes cancer “outside aggression”. Overall, this provides promising paradigm therapy.

Язык: Английский

---

The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities

Neoplasia, Год журнала: 2024, Номер 58, С. 101076 - 101076

Опубликована: Окт. 31, 2024

Язык: Английский

---