Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 7, 2025
Nanozymes
offer
diverse
therapeutic
potentials
for
cancer
treatment
which
is
dependent
on
the
development
of
nanomaterials.
Quasi-metal-organic
framework
a
class
metal-organic
framework-derived
nanomaterials
with
transition
state
from
frameworks
towards
metal
oxide
featuring
porous
structure
and
high
activity.
Herein
an
iron-based
quasi-metal-organic
nanozyme
Q-MIL-53(Fe)
reported
via
controlled
deligandation
strategy,
exhibiting
enhanced
peroxidase-/catalase-mimic
activity
glutathione
depletion
capacity,
whose
underlying
mechanisms
are
studied
density
functional
theory
calculations.
demonstrates
biocompatibility
superior
antitumor
efficacy
compared
to
pristine
MIL-53(Fe).
It
can
activate
immune
response
by
inducing
ferroptosis
immunogenic
cell
death,
promoting
dendritic
maturation
T
lymphocytes
infiltration.
Furthermore,
combination
programmed
death
protein
1
antibody
amplifies
immunotherapy.
This
study
validates
its
immunotherapy
induction
potential.
would
broaden
application
open
avenues
developing
nanozymes.
treatment.
In
this
work,
authors
report
quasi-metal
organic
peroxidase
catalase-mimicking
capacity
use
it
tumor
death.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Фев. 23, 2024
Abstract
Autophagy,
a
lysosome‐involved
degradation
pathway,
as
self‐protective
cellular
process,
always
weakens
the
efficiency
of
tumor
therapies.
Herein,
for
first
time,
biodegradable
copper
(Cu)
ions
doped
layered
double
hydroxide
(Cu‐LDH)
nanoparticles
are
reported
cancer
immunotherapy
via
lysosomal
rupture‐mediated
“Broken
Window
Effect”.
Only
injection
Cu‐LDH
single
therapeutic
agent
achieves
various
organelles
destruction
after
rupture,
well
abnormal
aggregation
Cu
in
cells
cuproptosis
and
pyroptosis.
More
importantly,
autophagy
inhibition
caused
by
rupture
improves
overload‐mediated
pyroptosis
blocking
lysosome‐mediated
bulk
leading
to
good
anti‐tumor
immune
responses
ultimately
high‐efficiency
growth
inhibition.
This
Effect”
provides
new
paradigm
enhanced
therapy.
Food Chemistry,
Год журнала:
2025,
Номер
unknown, С. 142751 - 142751
Опубликована: Янв. 1, 2025
Inorganic
nanozymes
hold
promise
for
biomolecule
sensing
but
face
challenges
like
complex
fabrication,
toxicity,
and
low
sustainability,
limiting
their
use.
To
overcome
these,
a
sustainable
organic
nanozyme
(OA
nanozyme)
was
created
using
amino
acids
biocompatible
polymer
effective
histamine
detection.
The
OA
exhibits
peroxidase-like
activity
fabricated
through
single
chelation/polymer
entanglement
method,
enabling
rapid
production
(within
3
h)
with
uniform
morphology
(≤100
nm
diameter)
negative
surface
charge
at
neutral
pH.
It
shows
decent
kinetic
performance
(Km
=
0.009
mM
H
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 22, 2025
Parkinson’s
disease
is
a
progressive
neurodegenerative
that
destroys
substantia
nigra
dopaminergic
neurons,
causing
tremors,
bradykinesia,
rigidity,
and
postural
instability.
Current
treatment
approaches
primarily
focus
on
symptom
management,
employing
pharmacological,
non-pharmacological,
surgical
methods.
However,
these
treatments
often
result
in
fluctuating
symptoms,
side
effects,
progression.
Here,
the
authors
have
reviewed
emerging
field
of
nanomedicine
as
promising
path
for
treatment,
emphasizing
its
potential
to
overcome
limitations
traditional
therapies.
Nanomedicine
utilizes
nanoparticles
targeted
drug
delivery,
leveraging
their
small
size
high
surface
area
volume
ratio
cross
blood-brain
barrier
deliver
therapeutic
agents
directly
affected
brain
regions.
Various
nanoparticles,
including
lipid-based,
polymeric,
metallic,
carbon-based,
shown
treatment.
Additionally,
nanocarrier
systems
like
liposomes,
nanogels,
dendrimers,
solid
lipid
offer
controlled
sustained
release
agents,
enhancing
bioavailability
reducing
effects.
This
review
provides
insights
into
pathophysiology
disease,
highlighting
mechanisms
neurodegeneration,
role
alpha-synuclein,
disruption
pathways.
It
further
discusses
application
gene
therapy
conjunction
with
interventions.
Theranostics,
Год журнала:
2024,
Номер
14(6), С. 2490 - 2525
Опубликована: Янв. 1, 2024
Inflammatory
dysregulation
is
intimately
associated
with
the
occurrence
and
progression
of
many
life-threatening
diseases.Accurate
detection
timely
therapeutic
intervention
on
inflammatory
are
crucial
for
effective
therapy
inflammation-associated
diseases.However,
clinical
outcomes
inflammation-involved
disorders
still
unsatisfactory.Therefore,
there
an
urgent
need
to
develop
innovative
anti-inflammatory
strategies
by
integrating
emerging
technological
innovations
traditional
therapeutics.Biomedical
nanotechnology
one
promising
fields
that
can
potentially
transform
diagnosis
treatment
inflammation.In
this
review,
we
outline
recent
advances
in
biomedical
inflammation,
special
attention
paid
nanosensors
nanoprobes
precise
inflammation-related
diseases,
nanotherapeutics,
as
well
nanotheranostics
combined
applications.Moreover,
prospects
challenges
translation
nanomedicines
highlighted.
Advanced Materials,
Год журнала:
2024,
Номер
36(45)
Опубликована: Сен. 17, 2024
Abstract
The
overexpression
of
polyamines
in
tumor
cells
contributes
to
the
establishment
immunosuppressive
microenvironment
and
facilitates
growth.
Here,
it
have
ingeniously
designed
multifunctional
copper‐piceatannol/HA
nanopills
(Cu‐Pic/HA
NPs)
that
effectively
cause
total
intracellular
depletion
by
inhibiting
synthesis,
depleting
polyamines,
impairing
uptake,
resulting
enhanced
pyroptosis
cuproptosis,
thus
activating
a
powerful
immune
response
achieve
anti‐tumor
therapy.
Mitochondrial
dysfunction
from
overall
not
only
leads
surge
copper
ions
mitochondria,
thereby
causing
aggregation
toxic
proteins
induce
but
also
triggers
accumulation
reactive
oxygen
species
(ROS)
within
which
further
upregulates
expression
zDHHC5
zDHHC9
promote
palmitoylation
gasdermin
D
(GSDMD)
GSDMD‐N,
ultimately
inducing
pyroptosis.
Then
occurrence
cuproptosis
is
conductive
remodel
microenvironment,
responses
growth
metastasis.
This
therapeutic
strategy
through
comprehensive
provides
novel
template
for
cancer
immunotherapy.
Nano Letters,
Год журнала:
2024,
Номер
24(24), С. 7321 - 7331
Опубликована: Май 24, 2024
While
oral
probiotics
show
promise
in
treating
inflammatory
bowel
disease,
the
primary
challenge
lies
sustaining
their
activity
and
retention
within
inflamed
gastrointestinal
environment.
In
this
work,
we
develop
an
engineered
probiotic
platform
that
is
armed
with
biocatalytic
colon-targeting
nanocoatings
for
multipronged
management
of
IBD.
Notably,
achieve
situ
growth
artificial
nanocatalysts
on
through
a
bioinspired
mineralization
strategy.
The
resulting
ferrihydrite
nanostructures
anchored
bacteria
exhibit
robust
catalase-like
across
broad
pH
range,
effectively
scavenging
ROS
to
alleviate
inflammation.
further
envelopment
fucoidan-based
shields
confers
additional
functions.
Upon
administration,
display
markedly
improved
viability
colonization
intestine,
they
elicit
boosted
prophylactic
therapeutic
efficacy
against
colitis
synergistic
interplay
nanocatalysis-based
immunomodulation
probiotics-mediated
microbiota
reshaping.
multifunctional
platforms
offer
great
potential
comprehensive
disorders.
