Journal of Neuroimaging,
Год журнала:
2024,
Номер
34(6), С. 664 - 672
Опубликована: Окт. 27, 2024
Abstract
Background
and
Purpose
Carotid
artery
stenosis
is
a
major
risk
factor
for
ischemic
stroke.
Despite
carotid
stenting,
in‐stent
restenosis
(ISR)
remains
challenging.
Pigs
serve
as
an
ideal
ISR
model.
This
study
aims
to
establish
novel
porcine
model
of
using
open‐loop
closed‐loop
stents
assess
with
optical
coherence
tomography
(OCT)
histopathology,
comparing
incidence
vascular
response
between
stent
types.
Methods
Twelve
adult
male
Bama
miniature
pigs
underwent
stenting
either
or
stents.
The
animals
received
antiplatelet
therapy
pre‐
postimplantation.
Postimplantation
evaluations
at
90
days
included
digital
subtraction
angiography
(DSA),
OCT,
histopathological
examination,
electron
microscopy.
Results
Both
types
showed
detected
by
OCT
DSA.
revealed
comparable
neointimal
proliferation
within
struts
both
types,
no
significant
differences
in
stent,
lumen,
dimensions.
Histopathological
analysis
microscopy
provided
insights
into
tissue
responses
healing
processes
following
implantation.
No
difference
was
found
the
based
on
χ
2
test
(
p
=
.110).
hematoxylin‐eosin
staining
exhibit
highest
consistency
evaluating
area.
Conclusions
demonstrated
similar
outcomes
proved
be
highly
consistent
valuable
tool
arterial
conditions,
findings.
However,
due
small
sample
size,
validity
these
preliminary
findings
requires
further
investigation
confirmed.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Abstract
The
endothelial
glycocalyx
is
a
natural
protective
layer
for
blood
vessels.
Efficient
construction
of
reliable
glycocalyx‐mimetic
coating
on
vascular
implant
possesses
great
potential
but
remains
challenge.
Herein,
novel
featuring
the
clustered
morphology
and
hydrophilic
lubrication
developed
via
layer‐by‐layer
self‐assembly
polyethyleneimine
(PEI)
phosphorylcholine‐modified
hyaluronic
acid
(HA‐PC).
zwitterionic
PC
groups
in
HA‐PC
exhibited
an
anti‐polyelectrolyte
effect
to
induce
molecular
folding
aggregation
HA
solution
enhance
its
binding
capacity
PEI,
resulting
morphology.
Besides,
zwitterions,
rather
than
hydrophobic
groups,
can
achieve
properties
through
spatial
synergy
with
while
inducing
HA,
ultimately
constructing
coating.
Such
function
well
as
armor
stent,
by
virtue
excellent
anti‐coagulation,
anti‐inflammation,
promotion
vivo
vitro.
findings
not
only
provide
new
insights
into
interactions
between
PC‐modified
polyelectrolytes
also
render
promising
implants.
Bile
duct
injuries
remain
a
significant
clinical
challenge
following
hepatobiliary
surgeries.
Recently,
3D-printed
tubular
scaffolds
have
shown
promise
as
effective
solutions
for
bile
tissue
repair.
This
study
presents
novel
bi-layered
scaffold,
fabricated
using
advanced
three-dimensional
printing
technology.
The
inner
layer
of
this
scaffold
is
constructed
from
poly(ε-caprolactone)
methacrylate
(PCLMA),
which
imparts
high
mechanical
strength.
outer
composed
biocompatible
methacrylated
recombinant
type
I
collagen
(rColMA)
and
ε-poly(L-lysine)-methacrylamide
(EPLMA),
providing
excellent
antibacterial
properties.
In
addition,
encapsulated
interleukin-6-loaded
liposomes
(IL-6@Lip)
are
incorporated
into
the
to
further
promote
regeneration.
innovative
design
creates
an
optimal
microenvironment
growth
differentiation
bone
marrow
mesenchymal
stem
cells
(BMSCs)
duct-like
cells.
These
differentiated
contribute
regeneration,
evidenced
by
expression
key
markers,
including
CK7,
CK19,
AQP1,
AE2,
CX43.
rColMA/EPLMA/IL-6@Lip
hydrogel
in
significantly
enhances
BMSC
proliferation
their
epithelial
Furthermore,
vivo
experiments
show
that
PCLMA//rColMA/EPLMA/IL-6@Lip
does
not
induce
stasis.
novel,
pre-differentiated
active
offers
valuable
insights
regeneration
replacement
research.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Abstract
Despite
the
development
of
many
injectable
hydrogels
intended
for
repair
myocardial
infarction
(MI),
their
effectiveness
is
often
compromised
because
they
target
merely
one
or
two
phases
MI's
pathological
progression.
Here,
a
multifunctional
hydrogel
delivery
platform
prepared
with
brand‐new
small
molecule
cross‐linker
stepwise
treatment
MI.
The
synthesis
and
reporting
novel
small‐molecule
phenylboronic
acid
((N(BA)
3
))
precise
molecular
structure
conducted
first
time,
it
successfully
utilized
polyvinyl
alcohol
(PVA)
dopamine
to
prepare
infarct
microenvironmental
responsiveness
anti‐oxidant.
Further,
considering
multistage
MI
repair,
contains
both
hyperoside
bioactive
nanoparticles
(EGCG@Hyp&Arg
NPs)
PLGA
microspheres
loaded
galunisertib
(PLGA@Gal
Ms).
EGCG@Hyp&Arg
NPs
are
rapidly
released
demonstrate
anti‐inflammatory
pro‐angiogenesis
effects,
while
in
long
term,
Gal
from
PLGA@Gal
Ms
inhibit
fibrosis
improve
cardiac
function.
Results
vitro
vivo
studies
reveal
that
engineered
programmed
capabilities
anti‐oxidation,
reducing
inflammation,
promoting
new
blood
vessel
formation,
inhibiting
fibrosis,
thereby
significantly
enhancing
heart
function
post‐MI.
Overall,
this
has
great
potential
application
as
therapeutic
strategy
Stent
implantation
remains
a
cornerstone
of
interventional
cardiology,
providing
minimally
invasive
solution
to
restore
blood
flow
in
occluded
vessels.
However,
current
stents
face
persistent
challenges
simultaneously
preventing
neointimal
hyperplasia
and
promoting
reendothelialization,
compromising
their
long-term
efficacy.
To
address
these
limitations,
we
developed
an
situ
H2S-releasing
polymer
brush-coated
stent
that
actively
modulates
material–blood
interactions,
creating
favorable
microenvironment
for
vascular
healing.
H2S
enhances
the
stent's
antithrombotic
properties
by
inhibiting
fibrinogen
binding
platelet
activation,
while
also
mitigating
oxidative
stress
macrophage
polarization
toward
anti-inflammatory
M2
phenotype.
In
vivo,
significantly
improved
healing
accelerating
endothelialization
smooth
muscle
cell
overproliferation,
resulting
thinner
neointima
with
functional
endothelial
coverage.
Transcriptomic
analysis
further
elucidated
underlying
mechanisms,
revealing
H2S-mediated
modulation
key
biological
pathways
support
These
findings
underscore
potential
release
as
effective
strategy
optimizing
implants
improving
outcomes.
