Association between serum urate levels and all-cause mortality, cardiovascular and renal outcomes among gout patients in Singapore DOI Creative Commons
Moses Yidong Lim, Weixiang Lian, Hwee Pin Phua

и другие.

BMC Rheumatology, Год журнала: 2024, Номер 8(1)

Опубликована: Дек. 20, 2024

We investigated the longitudinal association between Serum Urate (SU) level and Acute Myocardial Infarction (AMI), Stroke, End Stage Renal Failure (ESRF) all-cause mortality. conducted a retrospective hospital-based cohort study of individuals with gout managed in specialist outpatient clinics. Cox proportional hazards regression was used to estimate HR 95% CI, adjustments for potential confounders. Where hazard assumption violated, stratified applied instead. An acute care tertiary hospital Singapore. Individuals first diagnosis 2007–2017, identified through (i) primary discharge diagnosis, (ii) from Rheumatology SOC (iii) patient history clinical encounter at plus use urate-lowering therapy/colchicine. All-cause mortality, AMI, Stroke ESRF ascertained data linkage National Registry Diseases Office. The final comprised 2,866 individuals. Post follow-up, there were 800 deaths 362, 218 191 occurrences stroke respectively. Compared reference (second-lowest) SU quartile, being highest quartile associated significantly increased mortality (HR:1.66, CI:1.36–2.03), incident (HR:3.02, CI:2.00-4.56), AMI (HR:1.42, CI:1.06–1.91). p-trend all 3 outcomes significant. No significant found stroke. This that who had higher baseline levels an ESRF, AMI. Not applicable.

Язык: Английский

The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies DOI
Megan Leask, Tania O. Crişan, Aichang Ji

и другие.

Nature Reviews Rheumatology, Год журнала: 2024, Номер 20(8), С. 510 - 523

Опубликована: Июль 11, 2024

Язык: Английский

Процитировано

14
The changing burden of gout in adults aged 70 and above based on the global burden of disease 2019 DOI Creative Commons
Yang Yang, Zhong Liu

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Фев. 6, 2025

Gout is a significant global health issue, particularly among adults aged 70 and above. Understanding its epidemiological evolution associated factors crucial for guiding interventions improving management. This study analyzed data from the Global Burden of Disease to assess prevalence trends gout above 1990 2019. We evaluated temporal regional disparities by calculating estimated annual percentage change (EAPCs). Globally, number older individuals affected increased 5,316,210 cases in 15,666,063 It noteworthy that burden continued rise 2019, with an EAPC 1.17 (95% CI: 1.02 1.32). In rates 70-74, 75-79, 80-84, 85 were 3,121.31 per 100,000, 3,437.17 3,592.38 3,726.91 respectively. The regions highest 2019 Australasia, High-income North America, Southern Latin 8,500.73, 8,351.33, 4,666.87 At national level, some developed countries such as New Zealand, United States Australia had rates, reaching 8,893.74, 8,508.06, 8,427.94 higher levels Socio-Demographic Index tended have relatively adults, varied across different age groups. underscores persistent emphasizing need targeted address this issue improve public outcomes demographic.

Язык: Английский

Процитировано

1
Universal Thermal Climate Index influences on uric acid levels and hyperuricemia: Insights from a large-scale population study DOI Creative Commons
Yufen Zheng,

Minya Jin,

Linyan Cheng

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 149, С. 114224 - 114224

Опубликована: Фев. 6, 2025

Язык: Английский

Процитировано

0
Purine metabolism-associated key genes depict the immune landscape in gout patients DOI Creative Commons

Lin-na Li,

Hao Wang, Lushan Xiao

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 17, 2025

Язык: Английский

Процитировано

0
Association Between Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Abdominal Aortic Aneurysm: A Single-Center Retrospective Study DOI Creative Commons
Da-Yong Lu, Ke Si, Guijun Huo

и другие.

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 3217 - 3226

Опубликована: Март 1, 2025

Uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) has been recognized as a novel biomarker for evaluating inflammatory and anti-inflammatory interaction. However, it is not known whether UHR related abdominal aortic aneurysm (AAA). The current research aims explore the potential role of in predicting AAA. In this study, 303 AAA patients 408 normal subjects were retrospectively analyzed. relationship between was evaluated using Logistic regression models. Receiver operating characteristic (ROC) curves restricted cubic spline (RCS) analysis employed elucidate detailed association value group significantly higher than that group, UHA an independent risk factor After adjusting covariates, each 1-unit increase associated with 12% rise (OR: 1.12, 95% CI: 1.03, 1.21). ROC 0.847 (95% CI, 0.811~0.887, P < 0.05), optimal critical 17.2%. incidence UHR≥17.2% 17.2% group. RCS revealed significant nonlinear events (p-value 0.001, p-nonlinear = 0.002). This study demonstrates levels are linked increased risk, which can be widely used indicator dynamic screening

Язык: Английский

Процитировано

0
Metabolic diseases in the East Asian populations DOI
Zhonghan Sun, Yan Zheng

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0
A genome-wide association study of neonatal metabolites DOI Creative Commons
Quanze He, Hankui Liu,

Lu Lu

и другие.

Cell Genomics, Год журнала: 2024, Номер 4(10), С. 100668 - 100668

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

1
The Genetic Variants Influencing Hypertension Prevalence Based on the Risk of Insulin Resistance as Assessed Using the Metabolic Score for Insulin Resistance (METS-IR) DOI Open Access
B Shine, Ja‐Eun Choi, Youngjin Park

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12690 - 12690

Опубликована: Ноя. 26, 2024

Insulin resistance is a major indicator of cardiovascular diseases, including hypertension. The Metabolic Score for Resistance (METS-IR) offers simplified and cost-effective way to evaluate insulin resistance. This study aimed identify genetic variants associated with the prevalence hypertension stratified by METS-IR score levels. Data from Korean Genome Epidemiology Study (KoGES) were analyzed. was calculated using following formula: ln [(2 × fasting blood glucose (FBG) + triglycerides (TG)) body mass index (BMI)]/ [high-density lipoprotein cholesterol (HDL-C)]. participants divided into tertiles 1 (T1) 3 (T3) based on their scores. Genome-wide association studies (GWAS) performed hypertensive cases non-hypertensive controls within these tertile groups logistic regression adjusted age, sex, lifestyle factors. Among groups, 3517 19,774 (17.8%) at T1 had hypertension, whereas 8653 20,374 (42.5%) T3 A total 113 single-nucleotide polymorphisms (SNPs) reached GWAS significance threshold (

Язык: Английский

Процитировано

1
A Genome-Wide Association Study of Oxypurinol Concentrations in Patients Treated with Allopurinol DOI Open Access
Maxime Meloche, Marc‐Olivier Pilon, Sylvie Provost

и другие.

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(6), С. 649 - 649

Опубликована: Июнь 18, 2024

Cohort studies have identified several genetic determinants that could predict the clinical response to allopurinol. However, they not been commonly used for genome-wide investigations identify on allopurinol metabolism and concentrations. We conducted a association study of prior cross-sectional investigation patients from Montreal Heart Institute Biobank undergoing therapy. Four endpoints were investigated, namely plasma concentrations oxypurinol, active metabolite allopurinol, allopurinol-riboside, as well daily dosing. A total 439 participants (mean age 69.4 years; 86.4% male) taking dose 194.5 mg) who had quantifiable oxypurinol included in analyses. Participants presented with multiple comorbidities received concomitant cardiovascular medications. No achieved predefined threshold values any (all p > 5 × 10−8). Our results are consistent findings regarding difficulty identifying drug or pharmacokinetics its metabolites, Given size this study, collaborative involving larger diverse cohorts may be required further pharmacogenomic measure their relevance personalize

Язык: Английский

Процитировано

0
Hyperuricemia and epiretinal pathologies: a review of pathophysiological links and clinical implications DOI Creative Commons
Chun-Yao Cheng, Ju‐Chi Liu, Huan‐Yuan Chen

и другие.

Exploration of Medicine, Год журнала: 2024, Номер unknown, С. 732 - 749

Опубликована: Окт. 31, 2024

Hyperuricemia (HUA), defined by elevated serum uric acid levels, is well-established in its association with systemic conditions like gout and cardiovascular diseases. Recently, however, emerging research has revealed a potential connection between HUA ocular disorders, particularly epiretinal pathologies. This review investigates the pathophysiological mechanisms linking to conditions, including membrane formation, macular edema, retinal vascular By thoroughly analyzing current literature, this seeks deepen understanding of relationship aim informing new therapeutic strategies enhancing patient outcomes.

Язык: Английский

Процитировано

0